Chiral carboxylic acids and their effects on melting-point behaviour in co-crystals with isonicotinamide
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2008
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Acta Crystallographica Section B-Structural Science
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University of Cape Town
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Abstract
The crystal structures of co-crystals of two systems of chiral carboxylic acids, optically active and racemic 2-phenylpropionic acid and 2-phenylbutyric acid, with isonicotinamide are reported to investigate the effects of the chirality of the chiral carboxylic acids on the melting point of the co-crystal complexes. It was found that the racemic co-crystal has a higher melting point than the optically active co-crystal, which correlates with the denser packing arrangement inherent in centrosymmetric space groups.
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Lemmerer, A., Bathori, N. B., & Bourne, S. A. (2008). Chiral carboxylic acids and their effects on melting-point behaviour in co-crystals with isonicotinamide. Acta Crystallographica Section B: Structural Science, 64(6), 780-790.