Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig

Simple item page
dc.contributor.authorMarkos, F
dc.contributor.authorRuane‐O’Hora, T
dc.contributor.authorSnow, H M
dc.contributor.authorKelly, R
dc.contributor.authorWainwright, C
dc.contributor.authorSkene, K
dc.contributor.authorDrake-Holland, A J
dc.contributor.authorNoble, M I M
dc.date.accessioned2018-06-06T08:40:16Z
dc.date.available2018-06-06T08:40:16Z
dc.date.issued2008
dc.date.updated2016-01-20T10:04:18Z
dc.description.abstractAim:  We tested the hypothesis that dilatation of a feeding artery may be elicited by transmission of a signal through the tissue of the arterial wall from a vasodilated peripheral vascular bed. Methods:  In eight pentobarbital anaesthetized pigs, acetylcholine (ACh, an endothelium-dependent vasodilator) was injected intra-arterially above (upstream) and below (downstream) a test segment of the left iliac artery, the diameter of which was measured continuously by sonomicrometry. Results:  Under control conditions, ACh injections upstream and downstream of the test segment caused dilatation. Downstream injection dilated the peripheral arterioles, resulting in increased blood flow and proximal dilatation. This is a shear stress, nitric oxide (NO)-dependent response. The experiment was then repeated after applying a stenosis to prevent the increased flow caused by downstream injection of ACh; the stenosis was placed either above the site of diameter measurement to allow retrograde conduction, or below that site to prevent distally injected ACh reaching the measurement site. Under these conditions, downstream injection of ACh had a minimal effect on the shear stress of the test segment with no increase in test segment diameter. This was not due to endothelial damage or dysfunction as injection of ACh upstream still caused a large increase in test segment diameter. Conclusions:  Our results indicate that dilatation of the feeding artery of a vasodilated bed is caused by increased shear stress within the feeding artery and not via a signal transmitted through the arterial wall from below.
dc.identifierhttp://dx.doi.org/10.1111/j.1748-1716.2008.01882.x
dc.identifier.apacitationMarkos, F., , Snow, H. M., Kelly, R., Wainwright, C., Skene, K., ... Noble, M. I. M. (2008). Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig. <i>Acta Physiologica</i>, http://hdl.handle.net/11427/28231en_ZA
dc.identifier.chicagocitationMarkos, F, , H M Snow, R Kelly, C Wainwright, K Skene, A J Drake-Holland, and M I M Noble "Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig." <i>Acta Physiologica</i> (2008) http://hdl.handle.net/11427/28231en_ZA
dc.identifier.citationMarkos, F., Ruane‐O’Hora, T., Snow, H. M., Kelly, R., Wainwright, C., Skene, K., ... & Noble, M. I. M. (2008). Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig. Acta physiologica, 194(3), 207-213.
dc.identifier.ris TY - AU - Markos, F AU - Ruane‐O’Hora, T AU - Snow, H M AU - Kelly, R AU - Wainwright, C AU - Skene, K AU - Drake-Holland, A J AU - Noble, M I M AB - Aim:  We tested the hypothesis that dilatation of a feeding artery may be elicited by transmission of a signal through the tissue of the arterial wall from a vasodilated peripheral vascular bed. Methods:  In eight pentobarbital anaesthetized pigs, acetylcholine (ACh, an endothelium-dependent vasodilator) was injected intra-arterially above (upstream) and below (downstream) a test segment of the left iliac artery, the diameter of which was measured continuously by sonomicrometry. Results:  Under control conditions, ACh injections upstream and downstream of the test segment caused dilatation. Downstream injection dilated the peripheral arterioles, resulting in increased blood flow and proximal dilatation. This is a shear stress, nitric oxide (NO)-dependent response. The experiment was then repeated after applying a stenosis to prevent the increased flow caused by downstream injection of ACh; the stenosis was placed either above the site of diameter measurement to allow retrograde conduction, or below that site to prevent distally injected ACh reaching the measurement site. Under these conditions, downstream injection of ACh had a minimal effect on the shear stress of the test segment with no increase in test segment diameter. This was not due to endothelial damage or dysfunction as injection of ACh upstream still caused a large increase in test segment diameter. Conclusions:  Our results indicate that dilatation of the feeding artery of a vasodilated bed is caused by increased shear stress within the feeding artery and not via a signal transmitted through the arterial wall from below. DA - 2008 DB - OpenUCT DP - University of Cape Town J1 - Acta Physiologica LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig TI - Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig UR - http://hdl.handle.net/11427/28231 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/28231
dc.identifier.vancouvercitationMarkos F, , Snow HM, Kelly R, Wainwright C, Skene K, et al. Dilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig. Acta Physiologica. 2008; http://hdl.handle.net/11427/28231.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Cardiothoracic Surgeryen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceActa Physiologica
dc.source.urihttps://onlinelibrary.wiley.com/journal/17481716
dc.subject.otherendothelium
dc.subject.otherendothelium-dependent hyperpolarizing factor
dc.subject.othernitric oxide
dc.subject.othershear stress
dc.titleDilatation in the femoral vascular bed does not cause retrograde relaxation of the iliac artery in the anaesthetized pig
dc.typeJournal Article
uct.type.filetypeText
uct.type.filetypeImage
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Kelly_Article_2008.pdf
Size:
243.18 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.72 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles