A multivariable analysis of the contribution of socioeconomic and environmental factors to blood culture Escherichia Coli resistant to fluoroquinolones in high- and middle-income countries

Simple item page
dc.contributor.authorBooth, Amy
dc.contributor.authorWester, Astrid L
dc.date.accessioned2022-04-08T10:07:49Z
dc.date.available2022-04-08T10:07:49Z
dc.date.issued2022-02-19
dc.date.updated2022-02-20T04:19:08Z
dc.description.abstractBackground Antimicrobial resistance (AMR) is a public health concern. We wanted to determine if various environmental and socioeconomic variables as well as markers of antimicrobial use impacted on the level of AMR in countries of different income levels. Methods We performed cross-national univariate and multivariable analyses using the national proportion of quinolone-resistant Escherichia coli (QREC) in blood culture as the dependent variable. Access to safe water and sanitation, other socioeconomic variables, and human and animal antimicrobial consumption were analysed. Results In middle-income countries, unsafely managed sanitation, corruption and healthcare access and quality were significantly associated with the national proportion of blood culture QREC (%) in univariate analyses, whereas no variables remained significant in the multivariable models. For the multivariable high-income country model, corruption and healthcare access and quality were significantly associated with blood culture QREC (%) levels. For the model including all countries, human fluoroquinolone use, corruption level, livestock and crop production index were significantly associated with blood culture QREC (%) levels in the univariate analyses. Conclusion Corruption is a strong predictor of AMR, likely reflecting a multitude of socioeconomic factors. Sanitation quality contributed to increased blood culture QREC (%) levels in middle-income countries, although was not an independent factor, highlighting the need to also focus on infrastructure such as sanitation services in the context of AMR.en_US
dc.identifier.apacitationBooth, A., & Wester, A. L. (2022). A multivariable analysis of the contribution of socioeconomic and environmental factors to blood culture Escherichia Coli resistant to fluoroquinolones in high- and middle-income countries. <i>BMC Public Health</i>, 22(1), 354. http://hdl.handle.net/11427/36299en_ZA
dc.identifier.chicagocitationBooth, Amy, and Astrid L Wester "A multivariable analysis of the contribution of socioeconomic and environmental factors to blood culture Escherichia Coli resistant to fluoroquinolones in high- and middle-income countries." <i>BMC Public Health</i> 22, 1. (2022): 354. http://hdl.handle.net/11427/36299en_ZA
dc.identifier.citationBooth, A. & Wester, A.L. 2022. A multivariable analysis of the contribution of socioeconomic and environmental factors to blood culture Escherichia Coli resistant to fluoroquinolones in high- and middle-income countries. <i>BMC Public Health.</i> 22(1):354. http://hdl.handle.net/11427/36299en_ZA
dc.identifier.ris TY - Journal Article AU - Booth, Amy AU - Wester, Astrid L AB - Background Antimicrobial resistance (AMR) is a public health concern. We wanted to determine if various environmental and socioeconomic variables as well as markers of antimicrobial use impacted on the level of AMR in countries of different income levels. Methods We performed cross-national univariate and multivariable analyses using the national proportion of quinolone-resistant Escherichia coli (QREC) in blood culture as the dependent variable. Access to safe water and sanitation, other socioeconomic variables, and human and animal antimicrobial consumption were analysed. Results In middle-income countries, unsafely managed sanitation, corruption and healthcare access and quality were significantly associated with the national proportion of blood culture QREC (%) in univariate analyses, whereas no variables remained significant in the multivariable models. For the multivariable high-income country model, corruption and healthcare access and quality were significantly associated with blood culture QREC (%) levels. For the model including all countries, human fluoroquinolone use, corruption level, livestock and crop production index were significantly associated with blood culture QREC (%) levels in the univariate analyses. Conclusion Corruption is a strong predictor of AMR, likely reflecting a multitude of socioeconomic factors. Sanitation quality contributed to increased blood culture QREC (%) levels in middle-income countries, although was not an independent factor, highlighting the need to also focus on infrastructure such as sanitation services in the context of AMR. DA - 2022-02-19 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - BMC Public Health KW - Antimicrobial resistance KW - Quinolone-resistant Escherichia coli KW - Wastewater, sanitation, and hygiene KW - Antimicrobial usage KW - Corruption LK - https://open.uct.ac.za PY - 2022 T1 - A multivariable analysis of the contribution of socioeconomic and environmental factors to blood culture Escherichia Coli resistant to fluoroquinolones in high- and middle-income countries TI - A multivariable analysis of the contribution of socioeconomic and environmental factors to blood culture Escherichia Coli resistant to fluoroquinolones in high- and middle-income countries UR - http://hdl.handle.net/11427/36299 ER - en_ZA
dc.identifier.urihttps://doi.org/10.1186/s12889-022-12776-y
dc.identifier.urihttp://hdl.handle.net/11427/36299
dc.identifier.vancouvercitationBooth A, Wester AL. A multivariable analysis of the contribution of socioeconomic and environmental factors to blood culture Escherichia Coli resistant to fluoroquinolones in high- and middle-income countries. BMC Public Health. 2022;22(1):354. http://hdl.handle.net/11427/36299.en_ZA
dc.language.isoenen_US
dc.language.rfc3066en
dc.publisher.departmentDepartment of Public Health and Family Medicineen_US
dc.publisher.facultyFaculty of Health Sciencesen_US
dc.rights.holderThe Author(s)
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_US
dc.sourceBMC Public Healthen_US
dc.source.journalissue1en_US
dc.source.journalvolume22en_US
dc.source.pagination354en_US
dc.source.urihttps://bmcpublichealth.biomedcentral.com/
dc.subjectAntimicrobial resistanceen_US
dc.subjectQuinolone-resistant Escherichia colien_US
dc.subjectWastewater, sanitation, and hygieneen_US
dc.subjectAntimicrobial usageen_US
dc.subjectCorruptionen_US
dc.titleA multivariable analysis of the contribution of socioeconomic and environmental factors to blood culture Escherichia Coli resistant to fluoroquinolones in high- and middle-income countriesen_US
dc.typeJournal Articleen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
12889_2022_Article_12776.pdf
Size:
1.49 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles