Validation of a guideline-based composite outcome assessment tool for asthma control

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dc.contributor.authorSpencer, Sally
dc.contributor.authorMayer, Bhabita
dc.contributor.authorBendall, Kate L
dc.contributor.authorBateman, Eric D
dc.date.accessioned2021-10-08T07:15:59Z
dc.date.available2021-10-08T07:15:59Z
dc.date.issued2007
dc.description.abstractBackgroundA global definition of asthma control does not currently exist. The purpose of this study was to validate two new guideline-based composite measures of asthma control, defined as totally controlled (TC) asthma and well controlled (WC) asthma.MethodsWe used data from 3416 patients randomised and treated in the multi-centre Gaining Optimal Asthma controL (GOAL) study. The criteria comprising the asthma control measures were based on Global Initiative for Asthma/National Institutes of Health guidelines. This validation study examined the measurement properties of the asthma control measures using data from run-in, baseline, 12 and 52 weeks. Forced expiratory volume in 1 second (FEV1) and the Asthma Quality of Life Questionnaire (AQLQ) were used as the reference criteria in the validation analysis.ResultsBoth measures had good discriminative ability showing significant differences in FEV1 and AQLQ scores between control classification both cross-sectionally and longitudinally (p < 0.001). Overall both of the composite measures accounted for more of the variance in FEV1 after 52 weeks than the individual components of each asthma control measure. Both of the reference criteria were independently related to each asthma control measure (p < 0.0001). The measures also had good predictive validity showing significant differences in FEV1 and AQLQ scores at 52 weeks by control classification at 12 weeks (p < 0.0001).ConclusionThe guideline-based composite asthma control measures of WC asthma and TC asthma have good psychometric properties and are both valid functional indices of disease control in asthma.
dc.identifier.apacitationSpencer, S., Mayer, B., Bendall, K. L., & Bateman, E. D. (2007). Validation of a guideline-based composite outcome assessment tool for asthma control. <i>Respiratory Research</i>, 8(1), 174 - 177. http://hdl.handle.net/11427/34738en_ZA
dc.identifier.chicagocitationSpencer, Sally, Bhabita Mayer, Kate L Bendall, and Eric D Bateman "Validation of a guideline-based composite outcome assessment tool for asthma control." <i>Respiratory Research</i> 8, 1. (2007): 174 - 177. http://hdl.handle.net/11427/34738en_ZA
dc.identifier.citationSpencer, S., Mayer, B., Bendall, K.L. & Bateman, E.D. 2007. Validation of a guideline-based composite outcome assessment tool for asthma control. <i>Respiratory Research.</i> 8(1):174 - 177. http://hdl.handle.net/11427/34738en_ZA
dc.identifier.issn1465-9921
dc.identifier.issn1465-993X
dc.identifier.ris TY - Journal Article AU - Spencer, Sally AU - Mayer, Bhabita AU - Bendall, Kate L AU - Bateman, Eric D AB - BackgroundA global definition of asthma control does not currently exist. The purpose of this study was to validate two new guideline-based composite measures of asthma control, defined as totally controlled (TC) asthma and well controlled (WC) asthma.MethodsWe used data from 3416 patients randomised and treated in the multi-centre Gaining Optimal Asthma controL (GOAL) study. The criteria comprising the asthma control measures were based on Global Initiative for Asthma/National Institutes of Health guidelines. This validation study examined the measurement properties of the asthma control measures using data from run-in, baseline, 12 and 52 weeks. Forced expiratory volume in 1 second (FEV1) and the Asthma Quality of Life Questionnaire (AQLQ) were used as the reference criteria in the validation analysis.ResultsBoth measures had good discriminative ability showing significant differences in FEV1 and AQLQ scores between control classification both cross-sectionally and longitudinally (p < 0.001). Overall both of the composite measures accounted for more of the variance in FEV1 after 52 weeks than the individual components of each asthma control measure. Both of the reference criteria were independently related to each asthma control measure (p < 0.0001). The measures also had good predictive validity showing significant differences in FEV1 and AQLQ scores at 52 weeks by control classification at 12 weeks (p < 0.0001).ConclusionThe guideline-based composite asthma control measures of WC asthma and TC asthma have good psychometric properties and are both valid functional indices of disease control in asthma. DA - 2007 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Respiratory Research LK - https://open.uct.ac.za PY - 2007 SM - 1465-9921 SM - 1465-993X T1 - Validation of a guideline-based composite outcome assessment tool for asthma control TI - Validation of a guideline-based composite outcome assessment tool for asthma control UR - http://hdl.handle.net/11427/34738 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34738
dc.identifier.vancouvercitationSpencer S, Mayer B, Bendall KL, Bateman ED. Validation of a guideline-based composite outcome assessment tool for asthma control. Respiratory Research. 2007;8(1):174 - 177. http://hdl.handle.net/11427/34738.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Medicine
dc.publisher.facultyFaculty of Health Sciences
dc.sourceRespiratory Research
dc.source.journalissue1
dc.source.journalvolume8
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1186/1465-9921-8-26
dc.subject.otherAsthma
dc.subject.otherCross-Sectional Studies
dc.subject.otherForced Expiratory Volume
dc.subject.otherHumans
dc.subject.otherLongitudinal Studies
dc.subject.otherOutcome Assessment (Health Care)
dc.subject.otherPractice Guidelines as Topic
dc.subject.otherQuality of Life
dc.subject.otherSurveys and Questionnaires
dc.subject.otherTime Factors
dc.titleValidation of a guideline-based composite outcome assessment tool for asthma control
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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