Using quantitative ultrasound for epidemiological research : associations with risk factors for low bone mineral density in South African premenopausal women

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dc.contributor.advisorHoffman, Margareten_ZA
dc.contributor.authorConstant, Deborahen_ZA
dc.date.accessioned2014-11-08T18:07:53Z
dc.date.available2014-11-08T18:07:53Z
dc.date.issued2008en_ZA
dc.descriptionIncludes bibliographical references (leaves 57-63).en_ZA
dc.description.abstractQuantitative Ultrasound (QUS) measurement at the calcaneum is a convenient, cost effective and noninvasive method of determining bone strength well suited to community-based research in countries with limited resources. Although only moderately correlated with dual X-ray absorptiometry (DEXA) measurement of bone mineral density (BMD) at the hip and spine, quantitative ultrasound has shown to be a reliable predictor of osteoporotic fracture. This study aims to evaluate the use of QUS in epidemiological studies in South African settings. To this end, this report determines whether characteristics associated with QUS measures of bone strength in a large sample of premenopausal South African women are similar to those known to be associated with the BMD as measured by DEXA, and compares these associations with those in other populations. This cross-sectional study included 3493 black and mixed race women aged 18 - 44 living in Cape Town. Trained study nurses administered structured interviews on reproductive history and lifestyle factors. In addition they took height, weight and calcaneal QUS measurements using the Sahara device. Adjusted means of QUS measures according to categories of risk factors were obtained using multivariable regression analysis. In both groups associations between QUS measures and age, Body Mass Index (BMI), age at menarche, parity and primary school physical activity were similar to those known to be associated with BMD as measured by DEXA. There were no clear associations between QUS and educational level, alcohol use, cigarette smoking, and current calcium intake. The data give support to the use of QUS as an epidemiological tool in large studies of bone strength in premenopausal women.en_ZA
dc.identifier.apacitationConstant, D. (2008). <i>Using quantitative ultrasound for epidemiological research : associations with risk factors for low bone mineral density in South African premenopausal women</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Women's Health Research Unit. Retrieved from http://hdl.handle.net/11427/9416en_ZA
dc.identifier.chicagocitationConstant, Deborah. <i>"Using quantitative ultrasound for epidemiological research : associations with risk factors for low bone mineral density in South African premenopausal women."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Women's Health Research Unit, 2008. http://hdl.handle.net/11427/9416en_ZA
dc.identifier.citationConstant, D. 2008. Using quantitative ultrasound for epidemiological research : associations with risk factors for low bone mineral density in South African premenopausal women. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Constant, Deborah AB - Quantitative Ultrasound (QUS) measurement at the calcaneum is a convenient, cost effective and noninvasive method of determining bone strength well suited to community-based research in countries with limited resources. Although only moderately correlated with dual X-ray absorptiometry (DEXA) measurement of bone mineral density (BMD) at the hip and spine, quantitative ultrasound has shown to be a reliable predictor of osteoporotic fracture. This study aims to evaluate the use of QUS in epidemiological studies in South African settings. To this end, this report determines whether characteristics associated with QUS measures of bone strength in a large sample of premenopausal South African women are similar to those known to be associated with the BMD as measured by DEXA, and compares these associations with those in other populations. This cross-sectional study included 3493 black and mixed race women aged 18 - 44 living in Cape Town. Trained study nurses administered structured interviews on reproductive history and lifestyle factors. In addition they took height, weight and calcaneal QUS measurements using the Sahara device. Adjusted means of QUS measures according to categories of risk factors were obtained using multivariable regression analysis. In both groups associations between QUS measures and age, Body Mass Index (BMI), age at menarche, parity and primary school physical activity were similar to those known to be associated with BMD as measured by DEXA. There were no clear associations between QUS and educational level, alcohol use, cigarette smoking, and current calcium intake. The data give support to the use of QUS as an epidemiological tool in large studies of bone strength in premenopausal women. DA - 2008 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Using quantitative ultrasound for epidemiological research : associations with risk factors for low bone mineral density in South African premenopausal women TI - Using quantitative ultrasound for epidemiological research : associations with risk factors for low bone mineral density in South African premenopausal women UR - http://hdl.handle.net/11427/9416 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/9416
dc.identifier.vancouvercitationConstant D. Using quantitative ultrasound for epidemiological research : associations with risk factors for low bone mineral density in South African premenopausal women. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Women's Health Research Unit, 2008 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/9416en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentWomen's Health Research Uniten_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPublic Healthen_ZA
dc.titleUsing quantitative ultrasound for epidemiological research : associations with risk factors for low bone mineral density in South African premenopausal womenen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMPHen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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