High porosity electrospun scaffolds for small diameter vascular graft applications

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dc.contributor.advisorBezuidenhout, Deonen_ZA
dc.contributor.advisorBezuidenhout, Deonen_ZA
dc.contributor.advisorFranz, Thomasen_ZA
dc.contributor.authorVoorneveld, Jason Dirken_ZA
dc.date.accessioned2015-12-10T09:33:14Z
dc.date.available2015-12-10T09:33:14Z
dc.date.issued2015en_ZA
dc.description.abstractPorosity, pore size and pore interconnectivity have been shown to be critical factors for cellular infiltration into vascular grafts. While electrospinning has been shown to produce many promising characteristics for the fabrication of vascular graft scaffolds, it has yet to create sufficient porosity for transmural endothelial in-growth. This study was aimed at using dual electrospinning with sacrificial fibre extraction to produce scaffolds with controllable porosity characteristics while maintaining sufficient structural strength to resist deformation during implantation. Scaffolds were subsequently covalently grafted with heparin, a known anti-coagulant with growth-factor binding properties.en_ZA
dc.identifier.apacitationVoorneveld, J. D. (2015). <i>High porosity electrospun scaffolds for small diameter vascular graft applications</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Biomedical Engineering. Retrieved from http://hdl.handle.net/11427/15762en_ZA
dc.identifier.chicagocitationVoorneveld, Jason Dirk. <i>"High porosity electrospun scaffolds for small diameter vascular graft applications."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Biomedical Engineering, 2015. http://hdl.handle.net/11427/15762en_ZA
dc.identifier.citationVoorneveld, J. 2015. High porosity electrospun scaffolds for small diameter vascular graft applications. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Voorneveld, Jason Dirk AB - Porosity, pore size and pore interconnectivity have been shown to be critical factors for cellular infiltration into vascular grafts. While electrospinning has been shown to produce many promising characteristics for the fabrication of vascular graft scaffolds, it has yet to create sufficient porosity for transmural endothelial in-growth. This study was aimed at using dual electrospinning with sacrificial fibre extraction to produce scaffolds with controllable porosity characteristics while maintaining sufficient structural strength to resist deformation during implantation. Scaffolds were subsequently covalently grafted with heparin, a known anti-coagulant with growth-factor binding properties. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - High porosity electrospun scaffolds for small diameter vascular graft applications TI - High porosity electrospun scaffolds for small diameter vascular graft applications UR - http://hdl.handle.net/11427/15762 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15762
dc.identifier.vancouvercitationVoorneveld JD. High porosity electrospun scaffolds for small diameter vascular graft applications. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Biomedical Engineering, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/15762en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Biomedical Engineeringen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherBiomedical Engineeringen_ZA
dc.titleHigh porosity electrospun scaffolds for small diameter vascular graft applicationsen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMSc (Med)en_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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