The ancient evolutionary history of polyomaviruses

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dc.contributor.authorBuck, Christopher Ben_ZA
dc.contributor.authorVan Doorslaer, Koenraaden_ZA
dc.contributor.authorPeretti, Albertoen_ZA
dc.contributor.authorGeoghegan, Eileen Men_ZA
dc.contributor.authorTisza, Michael Jen_ZA
dc.contributor.authorAn, Pingen_ZA
dc.contributor.authorKatz, Joshua Pen_ZA
dc.contributor.authorPipas, James Men_ZA
dc.contributor.authorMcBride, Alison Aen_ZA
dc.contributor.authorCamus, Alvin Cen_ZA
dc.contributor.authorMcDermott, Alexa Jen_ZA
dc.contributor.authorDill, Jennifer Aen_ZA
dc.contributor.authorDelwart, Ericen_ZA
dc.contributor.authorNg, Terry F Fen_ZA
dc.contributor.authorFarkas, Kataen_ZA
dc.contributor.authorAustin, Charlotteen_ZA
dc.contributor.authorKraberger, Simonaen_ZA
dc.contributor.authorDavison, Williamen_ZA
dc.contributor.authorPastrana, Diana Ven_ZA
dc.contributor.authorVarsani, Arvinden_ZA
dc.date.accessioned2016-10-31T07:42:15Z
dc.date.available2016-10-31T07:42:15Z
dc.date.issued2016en_ZA
dc.description.abstractAuthor Summary: Polyomaviruses are a family of DNA-based viruses that are known to infect various terrestrial vertebrates, including humans. In this report, we describe our discovery of highly divergent polyomaviruses associated with various marine fish. Searches of public deep sequencing databases unexpectedly revealed the existence of polyomavirus-like sequences in scorpion and spider datasets. Our analysis of these new sequences suggests that polyomaviruses have slowly co-evolved with individual host animal lineages through an established mechanism known as intrahost divergence. The proposed model is similar to the mechanisms through with other DNA viruses, such as papillomaviruses, are thought to have evolved. Our analysis also suggests that distantly related polyomaviruses sometimes recombine to produce new chimeric lineages. We propose a possible taxonomic scheme that can account for these inferred ancient recombination events.en_ZA
dc.identifier.apacitationBuck, C. B., Van Doorslaer, K., Peretti, A., Geoghegan, E. M., Tisza, M. J., An, P., ... Varsani, A. (2016). The ancient evolutionary history of polyomaviruses. <i>PLoS One</i>, http://hdl.handle.net/11427/22372en_ZA
dc.identifier.chicagocitationBuck, Christopher B, Koenraad Van Doorslaer, Alberto Peretti, Eileen M Geoghegan, Michael J Tisza, Ping An, Joshua P Katz, et al "The ancient evolutionary history of polyomaviruses." <i>PLoS One</i> (2016) http://hdl.handle.net/11427/22372en_ZA
dc.identifier.citationBuck, C. B., Van Doorslaer, K., Peretti, A., Geoghegan, E. M., Tisza, M. J., An, P., ... & McDermott, A. J. (2016). The ancient evolutionary history of polyomaviruses. PLoS Pathog, 12(4), e1005574. doi:10.1371/journal.ppat.1005574en_ZA
dc.identifier.ris TY - Journal Article AU - Buck, Christopher B AU - Van Doorslaer, Koenraad AU - Peretti, Alberto AU - Geoghegan, Eileen M AU - Tisza, Michael J AU - An, Ping AU - Katz, Joshua P AU - Pipas, James M AU - McBride, Alison A AU - Camus, Alvin C AU - McDermott, Alexa J AU - Dill, Jennifer A AU - Delwart, Eric AU - Ng, Terry F F AU - Farkas, Kata AU - Austin, Charlotte AU - Kraberger, Simona AU - Davison, William AU - Pastrana, Diana V AU - Varsani, Arvind AB - Author Summary: Polyomaviruses are a family of DNA-based viruses that are known to infect various terrestrial vertebrates, including humans. In this report, we describe our discovery of highly divergent polyomaviruses associated with various marine fish. Searches of public deep sequencing databases unexpectedly revealed the existence of polyomavirus-like sequences in scorpion and spider datasets. Our analysis of these new sequences suggests that polyomaviruses have slowly co-evolved with individual host animal lineages through an established mechanism known as intrahost divergence. The proposed model is similar to the mechanisms through with other DNA viruses, such as papillomaviruses, are thought to have evolved. Our analysis also suggests that distantly related polyomaviruses sometimes recombine to produce new chimeric lineages. We propose a possible taxonomic scheme that can account for these inferred ancient recombination events. DA - 2016 DB - OpenUCT DO - 10.1371/journal.ppat.1005574 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - The ancient evolutionary history of polyomaviruses TI - The ancient evolutionary history of polyomaviruses UR - http://hdl.handle.net/11427/22372 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1371/journal.ppat.1005574en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/22372
dc.identifier.vancouvercitationBuck CB, Van Doorslaer K, Peretti A, Geoghegan EM, Tisza MJ, An P, et al. The ancient evolutionary history of polyomaviruses. PLoS One. 2016; http://hdl.handle.net/11427/22372.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDepartment of Clinical Laboratory Sciencesen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plospathogensen_ZA
dc.subject.otherPolyomavirusesen_ZA
dc.subject.otherSequence motif analysisen_ZA
dc.subject.otherPhylogenetic analysisen_ZA
dc.subject.otherDNA sequence analysisen_ZA
dc.subject.otherGenomic databasesen_ZA
dc.subject.otherViral evolutionen_ZA
dc.subject.otherSequence databasesen_ZA
dc.subject.otherInvertebrate genomicsen_ZA
dc.titleThe ancient evolutionary history of polyomavirusesen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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