Development of a method for the screening and quantification of methamphetamine, and its major metabolite amphetamine, in hair using liquid chromatography-tandem mass spectrometry

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dc.contributor.advisorSmith, Peteren_ZA
dc.contributor.advisorHeyns, Mariseen_ZA
dc.contributor.authorJohnston, Jennaen_ZA
dc.date.accessioned2015-08-27T12:29:29Z
dc.date.available2015-08-27T12:29:29Z
dc.date.issued2015en_ZA
dc.description.abstractHair has, over recent years, become widely recognised as an alternate or complementary matrix to blood and urine for drug analysis. Hair analysis offers a wider detection window after drug exposure than blood or urine testing and can provide a long-term history of an individual’s drug use. There are several practical applications of hair analysis for drugs including workplace drug testing, doping control, driving licence re-granting, drug-related deaths and drug-facilitated crimes. As a result hair analysis is currently being performed within various toxicological fields in laboratories around the world. However, before the start of this study no hair analysis for drugs was being performed in South Africa. Therefore, the main aim of this study, as stated in Chapter 1, was to develop a method for the detection and quantification of drugs of abuse, specifically methamphetamine and amphetamine, in hair using High Performance Liquid Chromatography coupled to Mass Spectrometry.en_ZA
dc.identifier.apacitationJohnston, J. (2015). <i>Development of a method for the screening and quantification of methamphetamine, and its major metabolite amphetamine, in hair using liquid chromatography-tandem mass spectrometry</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Forensic Medicine and Toxicology. Retrieved from http://hdl.handle.net/11427/13784en_ZA
dc.identifier.chicagocitationJohnston, Jenna. <i>"Development of a method for the screening and quantification of methamphetamine, and its major metabolite amphetamine, in hair using liquid chromatography-tandem mass spectrometry."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Forensic Medicine and Toxicology, 2015. http://hdl.handle.net/11427/13784en_ZA
dc.identifier.citationJohnston, J. 2015. Development of a method for the screening and quantification of methamphetamine, and its major metabolite amphetamine, in hair using liquid chromatography-tandem mass spectrometry. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Johnston, Jenna AB - Hair has, over recent years, become widely recognised as an alternate or complementary matrix to blood and urine for drug analysis. Hair analysis offers a wider detection window after drug exposure than blood or urine testing and can provide a long-term history of an individual’s drug use. There are several practical applications of hair analysis for drugs including workplace drug testing, doping control, driving licence re-granting, drug-related deaths and drug-facilitated crimes. As a result hair analysis is currently being performed within various toxicological fields in laboratories around the world. However, before the start of this study no hair analysis for drugs was being performed in South Africa. Therefore, the main aim of this study, as stated in Chapter 1, was to develop a method for the detection and quantification of drugs of abuse, specifically methamphetamine and amphetamine, in hair using High Performance Liquid Chromatography coupled to Mass Spectrometry. DA - 2015 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Development of a method for the screening and quantification of methamphetamine, and its major metabolite amphetamine, in hair using liquid chromatography-tandem mass spectrometry TI - Development of a method for the screening and quantification of methamphetamine, and its major metabolite amphetamine, in hair using liquid chromatography-tandem mass spectrometry UR - http://hdl.handle.net/11427/13784 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13784
dc.identifier.vancouvercitationJohnston J. Development of a method for the screening and quantification of methamphetamine, and its major metabolite amphetamine, in hair using liquid chromatography-tandem mass spectrometry. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Forensic Medicine and Toxicology, 2015 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/13784en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Forensic Medicine and Toxicologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherBiomedical Forensic Scienceen_ZA
dc.titleDevelopment of a method for the screening and quantification of methamphetamine, and its major metabolite amphetamine, in hair using liquid chromatography-tandem mass spectrometryen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMPhilen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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