High prevalence of self-reported undiagnosed HIV despite high coverage of HIV testing: a cross-sectional population based sero-survey in South Africa

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dc.contributor.authorKranzer, Katharinaen_ZA
dc.contributor.authorvan Schaik, Nienkeen_ZA
dc.contributor.authorKarmue, Uniceen_ZA
dc.contributor.authorMiddelkoop, Kerenen_ZA
dc.contributor.authorSebastian, Elaineen_ZA
dc.contributor.authorLawn, Stephen Den_ZA
dc.contributor.authorWood, Robinen_ZA
dc.contributor.authorBekker, Linda-Gailen_ZA
dc.date.accessioned2016-01-11T06:50:56Z
dc.date.available2016-01-11T06:50:56Z
dc.date.issued2011en_ZA
dc.description.abstractObjectives: To measure HIV prevalence and uptake of HIV counseling and testing (HCT) in a peri-urban South African community. To assess predictors for previous HIV testing and the association between the yield of previously undiagnosed HIV and time of last negative HIV test. METHODS: A random sample of 10% of the adult population (≥15 years) were invited to attend a mobile HCT service. Study procedures included a questionnaire, HIV testing and CD4 counts. Predictors for previous testing were determined using a binominal model. RESULTS: 1,144 (88.0%) of 1,300 randomly selected individuals participated in the study. 71.0% (68.3-73.6) had previously had an HIV test and 37.5% (34.6-40.5) had tested in the past 12 months. Men, migrants and older (>35 years) and younger (<20 years) individuals were less likely to have had a previous HIV test. Overall HIV prevalence was 22.7 (20.3-25.3) with peak prevalence of 41.8% (35.8-47.8) in women aged 25.1-35 years and 37.5% (26.7-48.3) in men aged 25.1-45 years. Prevalence of previously undiagnosed HIV was 10.3% (8.5-12.1) overall and 4.5% (2.3-6.6), 8.0% (CI 3.9-12.0) and 20.0% (13.2-26.8) in individuals who had their most recent HIV test within 1, 1-2 and more than 2 years prior to the survey. CONCLUSION: The high burden of undiagnosed HIV in individuals who had recently tested underscores the importance of frequent repeat testing at least annually. The high prevalence of previously undiagnosed HIV in individuals reporting a negative test in the 12 months preceding the survey indicates a very high incidence. Innovative prevention strategies are needed.en_ZA
dc.identifier.apacitationKranzer, K., van Schaik, N., Karmue, U., Middelkoop, K., Sebastian, E., Lawn, S. D., ... Bekker, L. (2011). High prevalence of self-reported undiagnosed HIV despite high coverage of HIV testing: a cross-sectional population based sero-survey in South Africa. <i>PLoS One</i>, http://hdl.handle.net/11427/16239en_ZA
dc.identifier.chicagocitationKranzer, Katharina, Nienke van Schaik, Unice Karmue, Keren Middelkoop, Elaine Sebastian, Stephen D Lawn, Robin Wood, and Linda-Gail Bekker "High prevalence of self-reported undiagnosed HIV despite high coverage of HIV testing: a cross-sectional population based sero-survey in South Africa." <i>PLoS One</i> (2011) http://hdl.handle.net/11427/16239en_ZA
dc.identifier.citationKranzer, K., van Schaik, N., Karmue, U., Middelkoop, K., & Sebastian, E. (2011).High prevalence of self-reported undiagnosed HIV despite high coverage of HIV testing: a cross-sectional population based sero-survey in South Africa.. PLoS ONE, 6(9), e25244. doi:10.1371/journal.pone.0025244en_ZA
dc.identifier.ris TY - Journal Article AU - Kranzer, Katharina AU - van Schaik, Nienke AU - Karmue, Unice AU - Middelkoop, Keren AU - Sebastian, Elaine AU - Lawn, Stephen D AU - Wood, Robin AU - Bekker, Linda-Gail AB - Objectives: To measure HIV prevalence and uptake of HIV counseling and testing (HCT) in a peri-urban South African community. To assess predictors for previous HIV testing and the association between the yield of previously undiagnosed HIV and time of last negative HIV test. METHODS: A random sample of 10% of the adult population (≥15 years) were invited to attend a mobile HCT service. Study procedures included a questionnaire, HIV testing and CD4 counts. Predictors for previous testing were determined using a binominal model. RESULTS: 1,144 (88.0%) of 1,300 randomly selected individuals participated in the study. 71.0% (68.3-73.6) had previously had an HIV test and 37.5% (34.6-40.5) had tested in the past 12 months. Men, migrants and older (>35 years) and younger (<20 years) individuals were less likely to have had a previous HIV test. Overall HIV prevalence was 22.7 (20.3-25.3) with peak prevalence of 41.8% (35.8-47.8) in women aged 25.1-35 years and 37.5% (26.7-48.3) in men aged 25.1-45 years. Prevalence of previously undiagnosed HIV was 10.3% (8.5-12.1) overall and 4.5% (2.3-6.6), 8.0% (CI 3.9-12.0) and 20.0% (13.2-26.8) in individuals who had their most recent HIV test within 1, 1-2 and more than 2 years prior to the survey. CONCLUSION: The high burden of undiagnosed HIV in individuals who had recently tested underscores the importance of frequent repeat testing at least annually. The high prevalence of previously undiagnosed HIV in individuals reporting a negative test in the 12 months preceding the survey indicates a very high incidence. Innovative prevention strategies are needed. DA - 2011 DB - OpenUCT DO - 10.1371/journal.pone.0025244 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - High prevalence of self-reported undiagnosed HIV despite high coverage of HIV testing: a cross-sectional population based sero-survey in South Africa TI - High prevalence of self-reported undiagnosed HIV despite high coverage of HIV testing: a cross-sectional population based sero-survey in South Africa UR - http://hdl.handle.net/11427/16239 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/16239
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0025244
dc.identifier.vancouvercitationKranzer K, van Schaik N, Karmue U, Middelkoop K, Sebastian E, Lawn SD, et al. High prevalence of self-reported undiagnosed HIV despite high coverage of HIV testing: a cross-sectional population based sero-survey in South Africa. PLoS One. 2011; http://hdl.handle.net/11427/16239.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDesmond Tutu HIV Centreen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2011 Kranzer et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherHIVen_ZA
dc.subject.otherHIV diagnosis and managementen_ZA
dc.subject.otherHIV infectionsen_ZA
dc.subject.otherHIV preventionen_ZA
dc.subject.otherSouth Africaen_ZA
dc.subject.otherHIV epidemiologyen_ZA
dc.subject.otherAfricansen_ZA
dc.subject.otherAntiretroviral therapyen_ZA
dc.titleHigh prevalence of self-reported undiagnosed HIV despite high coverage of HIV testing: a cross-sectional population based sero-survey in South Africaen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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