HIV and pre-neoplastic and neoplastic lesions of the cervix in South Africa: a case-control study

Simple item page
dc.contributor.authorMoodley, Jenniferen_ZA
dc.contributor.authorHoffman, Margareten_ZA
dc.contributor.authorCarrara, Henrien_ZA
dc.contributor.authorAllan, Bruceen_ZA
dc.contributor.authorCooper, Dianeen_ZA
dc.contributor.authorRosenberg, Lynnen_ZA
dc.contributor.authorDenny, Lynetteen_ZA
dc.contributor.authorShapiro, Samuelen_ZA
dc.contributor.authorWilliamson, Anna-Liseen_ZA
dc.date.accessioned2015-10-12T10:54:47Z
dc.date.available2015-10-12T10:54:47Z
dc.date.issued2006en_ZA
dc.description.abstractBACKGROUND:Cervical cancer and infection with human immunodeficiency virus (HIV) are both major public health problems in South Africa. The aim of this study was to determine the risk of cervical pre-cancer and cancer among HIV positive women in South Africa. METHODS: Data were derived from a case-control study that examined the association between hormonal contraceptives and invasive cervical cancer. The study was conducted in the Western Cape (South Africa), from January 1998 to December 2001. There were 486 women with invasive cervical cancer, 103 control women with atypical squamous cells of undetermined significance (ASCUS), 53 with low-grade squamous intraepithelial lesions (LSIL), 50 with high-grade squamous intraepithelial lesions (HSIL) and 1159 with normal cytology. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multiple logistic regression. RESULTS: The adjusted odds ratios associated with HIV infection were: 4.4 [95% CI (2.3 - 8.4) for ASCUS, 7.4 (3.5 - 15.7) for LSIL, 5.8 (2.4 - 13.6) for HSIL and 1.17 (0.75 - 1.85) for invasive cervical cancer. HIV positive women were nearly 5 times more likely to have high-risk human papillomavirus infection (HR-HPV) present compared to HIV negative women [OR 4.6 (95 % CI 2.8 - 7.5)]. Women infected with both HIV and high-risk HPV had a more than 40 fold higher risk of SIL than women infected with neither of these viruses. CONCLUSION: HIV positive women were at an increased risk of cervical pre-cancer, but did not demonstrate an excess risk of invasive cervical cancer. An interaction between HIV and HR-HPV infection was demonstrated. Our findings underscore the importance of developing locally relevant screening and management guidelines for HIV positive women in South Africa.en_ZA
dc.identifier.apacitationMoodley, J., Hoffman, M., Carrara, H., Allan, B., Cooper, D., Rosenberg, L., ... Williamson, A. (2006). HIV and pre-neoplastic and neoplastic lesions of the cervix in South Africa: a case-control study. <i>BMC Cancer</i>, http://hdl.handle.net/11427/14186en_ZA
dc.identifier.chicagocitationMoodley, Jennifer, Margaret Hoffman, Henri Carrara, Bruce Allan, Diane Cooper, Lynn Rosenberg, Lynette Denny, Samuel Shapiro, and Anna-Lise Williamson "HIV and pre-neoplastic and neoplastic lesions of the cervix in South Africa: a case-control study." <i>BMC Cancer</i> (2006) http://hdl.handle.net/11427/14186en_ZA
dc.identifier.citationMoodley, J. R., Hoffman, M., Carrara, H., Allan, B. R., Cooper, D. D., Rosenberg, L., ... & Williamson, A. L. (2006). HIV and pre-neoplastic and neoplastic lesions of the cervix in South Africa: a case-control study. BMC cancer, 6(1), 135.en_ZA
dc.identifier.ris TY - Journal Article AU - Moodley, Jennifer AU - Hoffman, Margaret AU - Carrara, Henri AU - Allan, Bruce AU - Cooper, Diane AU - Rosenberg, Lynn AU - Denny, Lynette AU - Shapiro, Samuel AU - Williamson, Anna-Lise AB - BACKGROUND:Cervical cancer and infection with human immunodeficiency virus (HIV) are both major public health problems in South Africa. The aim of this study was to determine the risk of cervical pre-cancer and cancer among HIV positive women in South Africa. METHODS: Data were derived from a case-control study that examined the association between hormonal contraceptives and invasive cervical cancer. The study was conducted in the Western Cape (South Africa), from January 1998 to December 2001. There were 486 women with invasive cervical cancer, 103 control women with atypical squamous cells of undetermined significance (ASCUS), 53 with low-grade squamous intraepithelial lesions (LSIL), 50 with high-grade squamous intraepithelial lesions (HSIL) and 1159 with normal cytology. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using multiple logistic regression. RESULTS: The adjusted odds ratios associated with HIV infection were: 4.4 [95% CI (2.3 - 8.4) for ASCUS, 7.4 (3.5 - 15.7) for LSIL, 5.8 (2.4 - 13.6) for HSIL and 1.17 (0.75 - 1.85) for invasive cervical cancer. HIV positive women were nearly 5 times more likely to have high-risk human papillomavirus infection (HR-HPV) present compared to HIV negative women [OR 4.6 (95 % CI 2.8 - 7.5)]. Women infected with both HIV and high-risk HPV had a more than 40 fold higher risk of SIL than women infected with neither of these viruses. CONCLUSION: HIV positive women were at an increased risk of cervical pre-cancer, but did not demonstrate an excess risk of invasive cervical cancer. An interaction between HIV and HR-HPV infection was demonstrated. Our findings underscore the importance of developing locally relevant screening and management guidelines for HIV positive women in South Africa. DA - 2006 DB - OpenUCT DO - 10.1186/1471-2407-6-135 DP - University of Cape Town J1 - BMC Cancer LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - HIV and pre-neoplastic and neoplastic lesions of the cervix in South Africa: a case-control study TI - HIV and pre-neoplastic and neoplastic lesions of the cervix in South Africa: a case-control study UR - http://hdl.handle.net/11427/14186 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14186
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2407-6-135
dc.identifier.vancouvercitationMoodley J, Hoffman M, Carrara H, Allan B, Cooper D, Rosenberg L, et al. HIV and pre-neoplastic and neoplastic lesions of the cervix in South Africa: a case-control study. BMC Cancer. 2006; http://hdl.handle.net/11427/14186.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentWomen's Health Research Uniten_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceBMC Canceren_ZA
dc.source.urihttp://www.biomedcentral.com/bmccancer/en_ZA
dc.subject.otherHIV/AIDSen_ZA
dc.subject.otherCervical canceren_ZA
dc.titleHIV and pre-neoplastic and neoplastic lesions of the cervix in South Africa: a case-control studyen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Moodley_HIV_pre_neoplastic_and_neoplastic_lesions_2006.pdf
Size:
245.44 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles