Cellular Receptors Involved in KSHV Infection
| dc.contributor.author | van der Meulen, Emma | |
| dc.contributor.author | Anderton, Meg | |
| dc.contributor.author | Blumenthal, Melissa J | |
| dc.contributor.author | Schäfer, Georgia | |
| dc.date.accessioned | 2021-10-18T10:13:27Z | |
| dc.date.available | 2021-10-18T10:13:27Z | |
| dc.date.issued | 2021-01-17 | |
| dc.date.updated | 2021-01-22T15:47:46Z | |
| dc.description.abstract | The process of Kaposi’s Sarcoma Herpes Virus’ (KSHV) entry into target cells is complex and engages several viral glycoproteins which bind to a large range of host cell surface molecules. Receptors for KSHV include heparan sulphate proteoglycans (HSPGs), several integrins and Eph receptors, cystine/glutamate antiporter (xCT) and Dendritic Cell-Specific Intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN). This diverse range of potential binding and entry sites allows KSHV to have a broad cell tropism, and entry into specific cells is dependent on the available receptor repertoire. Several molecules involved in KSHV entry have been well characterized, particularly those postulated to be associated with KSHV-associated pathologies such as Kaposi’s Sarcoma (KS). In this review, KSHV infection of specific cell types pertinent to its pathogenesis will be comprehensively summarized with a focus on the specific cell surface binding and entry receptors KSHV exploits to gain access to a variety of cell types. Gaps in the current literature regarding understanding interactions between KSHV glycoproteins and cellular receptors in virus infection are identified which will lead to the development of virus infection intervention strategies. | en_US |
| dc.identifier | doi: 10.3390/v13010118 | |
| dc.identifier.apacitation | van der Meulen, E., Anderton, M., Blumenthal, M. J., & Schäfer, G. (2021). Cellular Receptors Involved in KSHV Infection. <i>Viruses</i>, 13(1), http://hdl.handle.net/11427/35263 | en_ZA |
| dc.identifier.chicagocitation | van der Meulen, Emma, Meg Anderton, Melissa J Blumenthal, and Georgia Schäfer "Cellular Receptors Involved in KSHV Infection." <i>Viruses</i> 13, 1. (2021) http://hdl.handle.net/11427/35263 | en_ZA |
| dc.identifier.citation | van der Meulen, E., Anderton, M., Blumenthal, M.J. & Schäfer, G. 2021. Cellular Receptors Involved in KSHV Infection. <i>Viruses.</i> 13(1) http://hdl.handle.net/11427/35263 | en_ZA |
| dc.identifier.ris | TY - Journal Article AU - van der Meulen, Emma AU - Anderton, Meg AU - Blumenthal, Melissa J AU - Schäfer, Georgia AB - The process of Kaposi’s Sarcoma Herpes Virus’ (KSHV) entry into target cells is complex and engages several viral glycoproteins which bind to a large range of host cell surface molecules. Receptors for KSHV include heparan sulphate proteoglycans (HSPGs), several integrins and Eph receptors, cystine/glutamate antiporter (xCT) and Dendritic Cell-Specific Intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN). This diverse range of potential binding and entry sites allows KSHV to have a broad cell tropism, and entry into specific cells is dependent on the available receptor repertoire. Several molecules involved in KSHV entry have been well characterized, particularly those postulated to be associated with KSHV-associated pathologies such as Kaposi’s Sarcoma (KS). In this review, KSHV infection of specific cell types pertinent to its pathogenesis will be comprehensively summarized with a focus on the specific cell surface binding and entry receptors KSHV exploits to gain access to a variety of cell types. Gaps in the current literature regarding understanding interactions between KSHV glycoproteins and cellular receptors in virus infection are identified which will lead to the development of virus infection intervention strategies. DA - 2021-01-17 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - Viruses LK - https://open.uct.ac.za PY - 2021 T1 - Cellular Receptors Involved in KSHV Infection TI - Cellular Receptors Involved in KSHV Infection UR - http://hdl.handle.net/11427/35263 ER - | en_ZA |
| dc.identifier.uri | https://doi.org/10.3390/v13010118 | |
| dc.identifier.uri | http://hdl.handle.net/11427/35263 | |
| dc.identifier.vancouvercitation | van der Meulen E, Anderton M, Blumenthal MJ, Schäfer G. Cellular Receptors Involved in KSHV Infection. Viruses. 2021;13(1) http://hdl.handle.net/11427/35263. | en_ZA |
| dc.language.iso | en | en_US |
| dc.publisher.department | Institute of Infectious Disease and Molecular Medicine | en_US |
| dc.publisher.faculty | Faculty of Health Sciences | en_US |
| dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | en_US |
| dc.source | Viruses | en_US |
| dc.source.journalissue | 1 | en_US |
| dc.source.journalvolume | 13 | en_US |
| dc.source.uri | https://www.mdpi.com/journal/viruses | |
| dc.subject | Kaposi’s Sarcoma Herpes Virus (KSHV) | |
| dc.subject | Kaposi’s sarcoma | |
| dc.subject | Eph receptors | |
| dc.subject | endothelial cells | |
| dc.title | Cellular Receptors Involved in KSHV Infection | en_US |
| dc.type | Journal Article | en_US |