A retrospective review: The outcomes of patients with anal carcinoma receiving treatment at Groote Schuur Hospital

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dc.contributor.advisorHunter, Aen_ZA
dc.contributor.advisorRobertson, Barbaraen_ZA
dc.contributor.authorDalmeyer, Lisaen_ZA
dc.date.accessioned2017-06-06T09:36:14Z
dc.date.available2017-06-06T09:36:14Z
dc.date.issued2017en_ZA
dc.description.abstractObjectives: The objective of this study was to compare the outcome of two cohorts of patients with anal squamous carcinoma treated with split course chemoradiation as opposed to continuous chemoradiation at Groote Schuur Hospital. Demographics including age at diagnosis, gender and HIV status were reviewed. The stage at diagnosis, the acute treatment toxicities and all surgical procedures were noted. The outcomes included complete response rate, local control rate, loco-regional failure free survival, colostomy-free survival and overall survival. Design and Methods: The data was obtained from patient records of all patients with histologically confirmed anal squamous cell carcinoma seen and registered at the Department of Radiation Oncology at Groote Schuur Hospital. Patients included were those treated with radical intent that presented between the years of 2008 and 2012. This data was then compared with a similar study performed between 2000-2 004-. Results: A total of 72 patients diagnosed with anal squamous carcinoma were seen at Groote Schuur Hospital in the 5-year period, of which 4-0 patients fitted the criteria for this study. The median age was 53 years, with a slight male preponderance (55%) and 27.5% tested HIV positive. A total of 68% of patients had T3 and T4- disease, with 4-2.5% node positive disease. The complete response rate was 60%, the local control rate was 52.5% and the loco-regional failure free survival at 5 years was 56%. The colostomy-free survival was I-"4-% and the 5-year overall survival was 4-0.67%. Haematological, gastrointestinal and skin toxicities were reviewed and the most common acute side effect experienced was grade 2[32.5%] and grade 3[4-15%] skin toxicity. Conclusion: The patient characteristics and treatment toxicities are in keeping with previous study findings. However, complete response rate and overall survival were less than expected. Although there was no statistically significant difference in overall survival between the two cohorts of patients, there was a definite trend to inferior treatment outcomes of those patients treated with continuous chemoradiation. We propose radiation dose escalation for future treatment of patients presenting with anal carcinoma at Groote Schuur Hospital.en_ZA
dc.identifier.apacitationDalmeyer, L. (2017). <i>A retrospective review: The outcomes of patients with anal carcinoma receiving treatment at Groote Schuur Hospital</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Radiology. Retrieved from http://hdl.handle.net/11427/24484en_ZA
dc.identifier.chicagocitationDalmeyer, Lisa. <i>"A retrospective review: The outcomes of patients with anal carcinoma receiving treatment at Groote Schuur Hospital."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Radiology, 2017. http://hdl.handle.net/11427/24484en_ZA
dc.identifier.citationDalmeyer, L. 2017. A retrospective review: The outcomes of patients with anal carcinoma receiving treatment at Groote Schuur Hospital. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Dalmeyer, Lisa AB - Objectives: The objective of this study was to compare the outcome of two cohorts of patients with anal squamous carcinoma treated with split course chemoradiation as opposed to continuous chemoradiation at Groote Schuur Hospital. Demographics including age at diagnosis, gender and HIV status were reviewed. The stage at diagnosis, the acute treatment toxicities and all surgical procedures were noted. The outcomes included complete response rate, local control rate, loco-regional failure free survival, colostomy-free survival and overall survival. Design and Methods: The data was obtained from patient records of all patients with histologically confirmed anal squamous cell carcinoma seen and registered at the Department of Radiation Oncology at Groote Schuur Hospital. Patients included were those treated with radical intent that presented between the years of 2008 and 2012. This data was then compared with a similar study performed between 2000-2 004-. Results: A total of 72 patients diagnosed with anal squamous carcinoma were seen at Groote Schuur Hospital in the 5-year period, of which 4-0 patients fitted the criteria for this study. The median age was 53 years, with a slight male preponderance (55%) and 27.5% tested HIV positive. A total of 68% of patients had T3 and T4- disease, with 4-2.5% node positive disease. The complete response rate was 60%, the local control rate was 52.5% and the loco-regional failure free survival at 5 years was 56%. The colostomy-free survival was I-"4-% and the 5-year overall survival was 4-0.67%. Haematological, gastrointestinal and skin toxicities were reviewed and the most common acute side effect experienced was grade 2[32.5%] and grade 3[4-15%] skin toxicity. Conclusion: The patient characteristics and treatment toxicities are in keeping with previous study findings. However, complete response rate and overall survival were less than expected. Although there was no statistically significant difference in overall survival between the two cohorts of patients, there was a definite trend to inferior treatment outcomes of those patients treated with continuous chemoradiation. We propose radiation dose escalation for future treatment of patients presenting with anal carcinoma at Groote Schuur Hospital. DA - 2017 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2017 T1 - A retrospective review: The outcomes of patients with anal carcinoma receiving treatment at Groote Schuur Hospital TI - A retrospective review: The outcomes of patients with anal carcinoma receiving treatment at Groote Schuur Hospital UR - http://hdl.handle.net/11427/24484 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/24484
dc.identifier.vancouvercitationDalmeyer L. A retrospective review: The outcomes of patients with anal carcinoma receiving treatment at Groote Schuur Hospital. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Radiology, 2017 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/24484en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Radiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherRadiation Oncologyen_ZA
dc.titleA retrospective review: The outcomes of patients with anal carcinoma receiving treatment at Groote Schuur Hospitalen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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