Evolution of sensory neuropathy after initiation of antiretroviral therapy

Simple item page
dc.contributor.advisorHeckmann, Jeannine M
dc.contributor.authorCentner, Chad
dc.date.accessioned2019-02-18T10:39:50Z
dc.date.available2019-02-18T10:39:50Z
dc.date.issued2018
dc.date.updated2019-02-18T08:36:41Z
dc.description.abstractIntroduction: We studied the evolution of sensory neuropathy after antiretroviral therapy (ART) in human immunodeficiency virus–infected South Africans. Methods: Enrolment commenced before ART with 6-monthly follow-ups for 24 months. Symptomatic distal sensory polyneuropathy (SDSP) was defined as one symptom and sign. Symptom/sign scores were compared between visits. Results: We enrolled 184 participants. Pre-ART, 16% had SDSP. After 18 months of ART, pain prevalence decreased in those with pre-ART SDSP (odds ratio [OR], 0.09; 95% confidence interval [95%CI], 0.03-0.29). Symptoms improved in 50% ever experiencing pain (mean improvement=-4.5 on 11-point scale). Participants SDSP-free pre-ART developed SDSP at a rate of 18 per 100 person-years. After 24 months, 18% had SDSP. Stavudine (60% of cohort) did not predict incident SDSP, but associated with increased prevalence of reduced/absent reflexes at 18 months (OR, 2.24; 95% CI, 1.08-4.65). Conclusions: Painful symptoms improved during ART. Evolving sensory neuropathy was due to increasing small and large fiber dysfunction.
dc.identifier.apacitationCentner, C. (2018). <i>Evolution of sensory neuropathy after initiation of antiretroviral therapy</i>. (). University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology. Retrieved from http://hdl.handle.net/11427/29605en_ZA
dc.identifier.chicagocitationCentner, Chad. <i>"Evolution of sensory neuropathy after initiation of antiretroviral therapy."</i> ., University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology, 2018. http://hdl.handle.net/11427/29605en_ZA
dc.identifier.citationCentner, C. 2018. Evolution of sensory neuropathy after initiation of antiretroviral therapy. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Centner, Chad AB - Introduction: We studied the evolution of sensory neuropathy after antiretroviral therapy (ART) in human immunodeficiency virus–infected South Africans. Methods: Enrolment commenced before ART with 6-monthly follow-ups for 24 months. Symptomatic distal sensory polyneuropathy (SDSP) was defined as one symptom and sign. Symptom/sign scores were compared between visits. Results: We enrolled 184 participants. Pre-ART, 16% had SDSP. After 18 months of ART, pain prevalence decreased in those with pre-ART SDSP (odds ratio [OR], 0.09; 95% confidence interval [95%CI], 0.03-0.29). Symptoms improved in 50% ever experiencing pain (mean improvement=-4.5 on 11-point scale). Participants SDSP-free pre-ART developed SDSP at a rate of 18 per 100 person-years. After 24 months, 18% had SDSP. Stavudine (60% of cohort) did not predict incident SDSP, but associated with increased prevalence of reduced/absent reflexes at 18 months (OR, 2.24; 95% CI, 1.08-4.65). Conclusions: Painful symptoms improved during ART. Evolving sensory neuropathy was due to increasing small and large fiber dysfunction. DA - 2018 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2018 T1 - Evolution of sensory neuropathy after initiation of antiretroviral therapy TI - Evolution of sensory neuropathy after initiation of antiretroviral therapy UR - http://hdl.handle.net/11427/29605 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/29605
dc.identifier.vancouvercitationCentner C. Evolution of sensory neuropathy after initiation of antiretroviral therapy. []. University of Cape Town ,Faculty of Health Sciences ,Division of Medical Microbiology, 2018 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/29605en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Medical Microbiology
dc.publisher.facultyFaculty of Health Sciences
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMedical Microbiology
dc.titleEvolution of sensory neuropathy after initiation of antiretroviral therapy
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMed
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_hsf_2018_centner_chad.pdf
Size:
2.18 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Masters