Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital
| dc.contributor.advisor | Tooke, Lloyd | |
| dc.contributor.author | Browne, Bradley | |
| dc.date.accessioned | 2024-04-04T08:15:03Z | |
| dc.date.available | 2024-04-04T08:15:03Z | |
| dc.date.issued | 2023 | |
| dc.date.updated | 2024-04-04T06:48:57Z | |
| dc.description.abstract | Background. Group B Streptococcal disease is an important cause of morbidity and mortality in newborns globally, and is more common in Sub-Saharan Africa and South Africa. There are few studies reporting on the burden of invasive Group B Streptococcus disease (iGBS) in newborns in South Africa, especially in the Western Cape. Objective. This study aims to describe a case series of newborns with iGBS in a tertiary hospital in the Western Cape. Methods. A retrospective folder review was conducted between January 2015 and December 2020. Results. Thirty five cases of invasive GBS disease were included in the study, 51% with earlyonset disease (EoD) and 49% with late-onset disease (LoD). The median gestational age at birth was 27 and 31.5 weeks in the LoD and EoD groups respectively. The median birth weight was 900 g and 1812 g in the LoD and EoD group respectively. Meningits was more common in the LoD group, and pneumonia more common in the EoD group. The overall mortality rate was 23%, and GBS disease accounted for a cumulative 274 days in the intensive care unit. Conclusion. Invasive GBS disease in newborns at GSH carries a high mortality rate with a similar burden of LoD and EoD. More studies of newborn iGBS are needed in the Western Cape and South Africa to better understand the burden of disease. | |
| dc.identifier.apacitation | Browne, B. (2023). <i>ETD: Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital</i>. (). ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. Retrieved from http://hdl.handle.net/11427/39301 | en_ZA |
| dc.identifier.chicagocitation | Browne, Bradley. <i>"ETD: Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital."</i> ., ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2023. http://hdl.handle.net/11427/39301 | en_ZA |
| dc.identifier.citation | Browne, B. 2023. ETD: Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital. . ,Faculty of Health Sciences ,Department of Paediatrics and Child Health. http://hdl.handle.net/11427/39301 | en_ZA |
| dc.identifier.ris | TY - Thesis / Dissertation AU - Browne, Bradley AB - Background. Group B Streptococcal disease is an important cause of morbidity and mortality in newborns globally, and is more common in Sub-Saharan Africa and South Africa. There are few studies reporting on the burden of invasive Group B Streptococcus disease (iGBS) in newborns in South Africa, especially in the Western Cape. Objective. This study aims to describe a case series of newborns with iGBS in a tertiary hospital in the Western Cape. Methods. A retrospective folder review was conducted between January 2015 and December 2020. Results. Thirty five cases of invasive GBS disease were included in the study, 51% with earlyonset disease (EoD) and 49% with late-onset disease (LoD). The median gestational age at birth was 27 and 31.5 weeks in the LoD and EoD groups respectively. The median birth weight was 900 g and 1812 g in the LoD and EoD group respectively. Meningits was more common in the LoD group, and pneumonia more common in the EoD group. The overall mortality rate was 23%, and GBS disease accounted for a cumulative 274 days in the intensive care unit. Conclusion. Invasive GBS disease in newborns at GSH carries a high mortality rate with a similar burden of LoD and EoD. More studies of newborn iGBS are needed in the Western Cape and South Africa to better understand the burden of disease. DA - 2023 DB - OpenUCT DP - University of Cape Town KW - Paediatrics LK - https://open.uct.ac.za PY - 2023 T1 - ETD: Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital TI - ETD: Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital UR - http://hdl.handle.net/11427/39301 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/39301 | |
| dc.identifier.vancouvercitation | Browne B. ETD: Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital. []. ,Faculty of Health Sciences ,Department of Paediatrics and Child Health, 2023 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/39301 | en_ZA |
| dc.language.rfc3066 | eng | |
| dc.publisher.department | Department of Paediatrics and Child Health | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.subject | Paediatrics | |
| dc.title | Invasive Group B Streptococcal disease in newborns at Groote Schuur Hospital | |
| dc.type | Thesis / Dissertation | |
| dc.type.qualificationlevel | Masters | |
| dc.type.qualificationlevel | MMed |