Routine cryptococcal antigen screening for HIV-infected patients with low CD4+ T-lymphocyte counts - time to implement in South Africa?

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dc.contributor.authorJarvis, Joseph N
dc.contributor.authorHarrison, Thomas S
dc.contributor.authorGovender, Nelesh
dc.contributor.authorLawn, Stephen D
dc.contributor.authorLongley, Nicky
dc.contributor.authorBicanic, Tihana
dc.contributor.authorMaartens, Gary
dc.contributor.authorVenter, Francois
dc.contributor.authorBekker, Linda-Gail
dc.contributor.authorWood, Robin
dc.contributor.authorMeintjes, Graeme
dc.date.accessioned2017-05-26T09:02:07Z
dc.date.available2017-05-26T09:02:07Z
dc.date.issued2011
dc.date.updated2016-01-08T10:17:36Z
dc.description.abstractCryptococcal meningitis (CM) is a major cause of death among HIV-infected individuals. It causes an estimated 957 900 cases and 624 700 deaths worldwide annually, the vast majority of them in sub-Saharan Africa.1 In Cape Town, CM is now the most common cause of adult meningitis (63% of all microbiologically confirmed cases2), and acute outcomes are poor.3 Even with optimal treatment in study settings, 10-week mortality rates are between 24% and 37%.4,5 In 2009, in a routine care setting at an urban hospital in Johannesburg, 67% of patients had died or were lost to follow-up at 3 months (N Govender et al., unpublished data). Unfortunately almost half of South African patients still receive sub-optimal initial treatment with oral fluconazole rather than intravenous amphotericin B.3,6 Clearly, given the substantial mortality and morbidity associated with CM, preventive interventions should be prioritised.
dc.identifier.apacitationJarvis, J. N., Harrison, T. S., Govender, N., Lawn, S. D., Longley, N., Bicanic, T., ... Meintjes, G. (2011). Routine cryptococcal antigen screening for HIV-infected patients with low CD4+ T-lymphocyte counts - time to implement in South Africa?. <i>South African Medical Journal</i>, http://hdl.handle.net/11427/24418en_ZA
dc.identifier.chicagocitationJarvis, Joseph N, Thomas S Harrison, Nelesh Govender, Stephen D Lawn, Nicky Longley, Tihana Bicanic, Gary Maartens, et al "Routine cryptococcal antigen screening for HIV-infected patients with low CD4+ T-lymphocyte counts - time to implement in South Africa?." <i>South African Medical Journal</i> (2011) http://hdl.handle.net/11427/24418en_ZA
dc.identifier.citationJarvis, J. N., Harrison, T. S., Govender, N., Lawn, S. D., Longley, N., Bicanic, T., ... & Meintjes, G. (2011). Routine cryptococcal antigen screening for HIV-infected patients with low CD4+ T-lymphocyte counts: time to implement in South Africa?. SAMJ: South African Medical Journal, 101(4), 232-234.
dc.identifier.ris TY - Journal Article AU - Jarvis, Joseph N AU - Harrison, Thomas S AU - Govender, Nelesh AU - Lawn, Stephen D AU - Longley, Nicky AU - Bicanic, Tihana AU - Maartens, Gary AU - Venter, Francois AU - Bekker, Linda-Gail AU - Wood, Robin AU - Meintjes, Graeme AB - Cryptococcal meningitis (CM) is a major cause of death among HIV-infected individuals. It causes an estimated 957 900 cases and 624 700 deaths worldwide annually, the vast majority of them in sub-Saharan Africa.1 In Cape Town, CM is now the most common cause of adult meningitis (63% of all microbiologically confirmed cases2), and acute outcomes are poor.3 Even with optimal treatment in study settings, 10-week mortality rates are between 24% and 37%.4,5 In 2009, in a routine care setting at an urban hospital in Johannesburg, 67% of patients had died or were lost to follow-up at 3 months (N Govender et al., unpublished data). Unfortunately almost half of South African patients still receive sub-optimal initial treatment with oral fluconazole rather than intravenous amphotericin B.3,6 Clearly, given the substantial mortality and morbidity associated with CM, preventive interventions should be prioritised. DA - 2011 DB - OpenUCT DP - University of Cape Town J1 - South African Medical Journal LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Routine cryptococcal antigen screening for HIV-infected patients with low CD4+ T-lymphocyte counts - time to implement in South Africa? TI - Routine cryptococcal antigen screening for HIV-infected patients with low CD4+ T-lymphocyte counts - time to implement in South Africa? UR - http://hdl.handle.net/11427/24418 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/24418
dc.identifier.vancouvercitationJarvis JN, Harrison TS, Govender N, Lawn SD, Longley N, Bicanic T, et al. Routine cryptococcal antigen screening for HIV-infected patients with low CD4+ T-lymphocyte counts - time to implement in South Africa?. South African Medical Journal. 2011; http://hdl.handle.net/11427/24418.en_ZA
dc.language.isoeng
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceSouth African Medical Journal
dc.source.urihttp://www.samj.org.za/index.php/samj
dc.titleRoutine cryptococcal antigen screening for HIV-infected patients with low CD4+ T-lymphocyte counts - time to implement in South Africa?
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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