Persistent organic pollutants as risk factors for type 2 diabetes

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dc.contributor.authorNgwa, Elvisen_ZA
dc.contributor.authorKengne, Andre-Pascalen_ZA
dc.contributor.authorTiedeu-Atogho, Barbaraen_ZA
dc.contributor.authorMofo-Mato, Edith-Pascaleen_ZA
dc.contributor.authorSobngwi, Eugeneen_ZA
dc.date.accessioned2015-10-30T09:34:33Z
dc.date.available2015-10-30T09:34:33Z
dc.date.issued2015en_ZA
dc.description.abstractType 2 diabetes mellitus (T2DM) is a major and fast growing public health problem. Although obesity is considered to be the main driver of the pandemic of T2DM, a possible contribution of some environmental contaminants, of which persistent organic pollutants (POPs) form a particular class, has been suggested. POPs are organic compounds that are resistant to environmental degradation through chemical, biological, and photolytic processes which enable them to persist in the environment, to be capable of long-range transport, bio accumulate in human and animal tissue, bio accumulate in food chains, and to have potential significant impacts on human health and the environment. Several epidemiological studies have reported an association between persistent organic pollutants and diabetes risk. These findings have been replicated in experimental studies both in human (in-vitro) and animals (in-vivo and in-vitro), and patho-physiological derangements through which these pollutants exercise their harmful effect on diabetes risk postulated. This review summarizes available studies, emphasises on limitations so as to enable subsequent studies to be centralized on possible pathways and bring out clearly the role of POPs on diabetes risk.en_ZA
dc.identifier.apacitationNgwa, E., Kengne, A., Tiedeu-Atogho, B., Mofo-Mato, E., & Sobngwi, E. (2015). Persistent organic pollutants as risk factors for type 2 diabetes. <i>Diabetology & Metabolic Syndrome</i>, http://hdl.handle.net/11427/14530en_ZA
dc.identifier.chicagocitationNgwa, Elvis, Andre-Pascal Kengne, Barbara Tiedeu-Atogho, Edith-Pascale Mofo-Mato, and Eugene Sobngwi "Persistent organic pollutants as risk factors for type 2 diabetes." <i>Diabetology & Metabolic Syndrome</i> (2015) http://hdl.handle.net/11427/14530en_ZA
dc.identifier.citationNgwa, E. N., Kengne, A. P., Tiedeu-Atogho, B., Mofo-Mato, E. P., & Sobngwi, E. (2015). Persistent organic pollutants as risk factors for type 2 diabetes. Diabetology & metabolic syndrome, 7(1), 41.en_ZA
dc.identifier.ris TY - Journal Article AU - Ngwa, Elvis AU - Kengne, Andre-Pascal AU - Tiedeu-Atogho, Barbara AU - Mofo-Mato, Edith-Pascale AU - Sobngwi, Eugene AB - Type 2 diabetes mellitus (T2DM) is a major and fast growing public health problem. Although obesity is considered to be the main driver of the pandemic of T2DM, a possible contribution of some environmental contaminants, of which persistent organic pollutants (POPs) form a particular class, has been suggested. POPs are organic compounds that are resistant to environmental degradation through chemical, biological, and photolytic processes which enable them to persist in the environment, to be capable of long-range transport, bio accumulate in human and animal tissue, bio accumulate in food chains, and to have potential significant impacts on human health and the environment. Several epidemiological studies have reported an association between persistent organic pollutants and diabetes risk. These findings have been replicated in experimental studies both in human (in-vitro) and animals (in-vivo and in-vitro), and patho-physiological derangements through which these pollutants exercise their harmful effect on diabetes risk postulated. This review summarizes available studies, emphasises on limitations so as to enable subsequent studies to be centralized on possible pathways and bring out clearly the role of POPs on diabetes risk. DA - 2015 DB - OpenUCT DO - 10.1186/s13098-015-0031-6 DP - University of Cape Town J1 - Diabetology & Metabolic Syndrome LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Persistent organic pollutants as risk factors for type 2 diabetes TI - Persistent organic pollutants as risk factors for type 2 diabetes UR - http://hdl.handle.net/11427/14530 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14530
dc.identifier.urihttp://dx.doi.org/10.1186/s13098-015-0031-6
dc.identifier.vancouvercitationNgwa E, Kengne A, Tiedeu-Atogho B, Mofo-Mato E, Sobngwi E. Persistent organic pollutants as risk factors for type 2 diabetes. Diabetology & Metabolic Syndrome. 2015; http://hdl.handle.net/11427/14530.en_ZA
dc.language.isoengen_ZA
dc.publisherBiomed Central Ltden_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2015 Ngwa et al.; licensee BioMed Central.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourceDiabetology & Metabolic Syndromeen_ZA
dc.source.urihttp://www.dmsjournal.com/en_ZA
dc.subject.otherType 2 diabetesen_ZA
dc.subject.otherPersistent organic pollutantsen_ZA
dc.subject.otherIn utero exposureen_ZA
dc.subject.otherInsulin secretionen_ZA
dc.subject.otherInsulin resistanceen_ZA
dc.titlePersistent organic pollutants as risk factors for type 2 diabetesen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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