The effects of sertraline, alone and in combination with exercise on energy balance and eating behaviour in overweight women

Murphy, Kim

The effects of sertraline, alone and in combination with exercise on energy balance and eating behaviour in overweight women

Thesis / Dissertation

1996

Publisher

University of Cape Town

Department

Division of Physiological Sciences

Faculty

Faculty of Health Sciences

Abstract

An 18-week, double blind, placebo controlled trial was conducted on 31 overweight females to determine the effects of sertraline (STL) alone and sertraline in combination with exercise (EX) on body weight, body composition and total daily energy expenditure (24-hr-EE). Sedentary, non - depressed female volunteers were placebo (EX,PLC); . exercise randomly plus assigned sertraline to 4 groups:-exercise, (EX,STL); placebo (SED,PLC) and sedentary plus sertraline (SED,STL). Each group received dietary counselling for food energy and dietary fat restriction. After a 2-week placebo period, the sertraline groups received a 50mg.dai1 dose of sertraline which was up titrated to 200mg.dai1 over the 8-week trial period. The subjects in the exercise groups attended a 1-hour exercise (70-80% max) session, 3 times per week, for the 8-week intervention period. All measurements were repeated 8 weeks after withdrawal of treatment. Body weight decreased in all groups (P<0.05). Although the groups receiving sertraline lost significantly more weight than those receiving placebo (5.5±1.3 and 5.9±1.1 vs 2.5±1.1 and 2.1±1.1 for EX,STL and SED,STL vs. EX,PLC and SEO.PLC.), body fat decreased similarly in all groups (P<0.05). Resting metabolic rate (per kg.FFM-1) did not change significantly. Estimated 24 hr-EE, as determined using individual heart-rate-energy expenditure regression equations and 24-hr heart rate monitoring, increased significantly in the STL groups compared to PLC groups (P<0.01). Estimated 24hr energy expenditure increased in the EX, STL group following the intervention from 11.3 ± 0.5 MJ to 14.9 ± 0.5 MJ and 10.6 ± 0.7 MJ to 12.2 ± 0.05 MJ in the SEO, STL group. At follow up, 24 hr-EE decreased again in the STL groups. Reported food energy intake decreased in all groups (P<0.01), but there were no significant differences between groups. The Three Factor Eating Inventory showed an increase in Factor One or cognitive restraint and a decrease in Factor Three or hunger in all groups (P<0.01); Factor Two or disinhibition decreased significantly only in the groups receiving sertraline (P<0.01). Quality of life was not significantly affected by the drug or exercise treatment in these non-depressed subjects. These results suggest that the administration of STL to exercising and sedentary non - depressed women may result in significant weight loss, which may be attributed, in part, to an increased 24 hr-EE and greater control of energy intake.

Keywords

sertraline

energy

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