Antiprotozoal quinolines containing electrophilic moieties

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dc.contributor.advisorChibale, Kellyen_ZA
dc.contributor.authorGanto, Mlungiseleli Macdonalden_ZA
dc.date.accessioned2014-08-13T14:26:17Z
dc.date.available2014-08-13T14:26:17Z
dc.date.issued2004en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractCompounds containing the quinoline moiety have been the mainstay of antimalarial chemotherapy. However, the emergence of resistant strains of Plasmodium falciparum, the causative agent of malaria, has compromised the efficacy of these antimalarial quinolines. Therefore the development of new efficient drugs is of critical importance. Extensive research has identified the cysteine proteases in malaria and other parasitic diseases as potential targets for new chemotherapy due to their critical roles in the life cycles of the causative agents. Due to their role in the antimalarial activity of clinically available drugs, quinolines were used as scaffolds to which electrophilic groups, such as thiosemicarbazone, a,β-unsaturated ketone and pyrazoline moieties were appended.en_ZA
dc.identifier.apacitationGanto, M. M. (2004). <i>Antiprotozoal quinolines containing electrophilic moieties</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/6307en_ZA
dc.identifier.chicagocitationGanto, Mlungiseleli Macdonald. <i>"Antiprotozoal quinolines containing electrophilic moieties."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 2004. http://hdl.handle.net/11427/6307en_ZA
dc.identifier.citationGanto, M. 2004. Antiprotozoal quinolines containing electrophilic moieties. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Ganto, Mlungiseleli Macdonald AB - Compounds containing the quinoline moiety have been the mainstay of antimalarial chemotherapy. However, the emergence of resistant strains of Plasmodium falciparum, the causative agent of malaria, has compromised the efficacy of these antimalarial quinolines. Therefore the development of new efficient drugs is of critical importance. Extensive research has identified the cysteine proteases in malaria and other parasitic diseases as potential targets for new chemotherapy due to their critical roles in the life cycles of the causative agents. Due to their role in the antimalarial activity of clinically available drugs, quinolines were used as scaffolds to which electrophilic groups, such as thiosemicarbazone, a,β-unsaturated ketone and pyrazoline moieties were appended. DA - 2004 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2004 T1 - Antiprotozoal quinolines containing electrophilic moieties TI - Antiprotozoal quinolines containing electrophilic moieties UR - http://hdl.handle.net/11427/6307 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/6307
dc.identifier.vancouvercitationGanto MM. Antiprotozoal quinolines containing electrophilic moieties. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 2004 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/6307en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleAntiprotozoal quinolines containing electrophilic moietiesen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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