L-2 hydroxyglutaric aciduria in a South African Staffordshire Bull Terrier
| dc.contributor.author | Böhm, Marlies | |
| dc.contributor.author | Henderson, Howard | |
| dc.contributor.author | van der Zwan, Henriette | |
| dc.contributor.author | Basson, Sandra | |
| dc.date.accessioned | 2018-11-20T10:46:22Z | |
| dc.date.available | 2018-11-20T10:46:22Z | |
| dc.date.issued | 2014 | |
| dc.date.updated | 2018-11-20T10:44:52Z | |
| dc.description.abstract | L-2 hydroxyglutaric aciduria is an autosomal recessive error of metabolism that manifests as an encephalopathy. The most common presenting signs are seizures, tremors, ataxia and/ or dementia. Some affected dogs show only subtle behavioural changes. Amongst canines, the condition has been best described in Staffordshire Bull Terriers. Although this is the first reported case in South Africa, at least three other affected dogs have been indentified by polmerase chain reaction (PCR) in this country. Affected dogs have normal haematology, serum biochemistry and routine urine analysis. This report discusses the advantages and limitations of the three main diagnostic modalities, namely: magnetic resonance imaging, urine gas chromatography-mass spectrometry and genetic testing. The aim of this report is to increase awareness of the condition, assist diagnosis in encephalopathic dogs and improve detection of carriers amongst breeding stock. | |
| dc.identifier | http://dx.doi.org/10.4102/jsava. v85i1.1042 | |
| dc.identifier.apacitation | Böhm, M., Henderson, H., van der Zwan, H., & Basson, S. (2014). L-2 hydroxyglutaric aciduria in a South African Staffordshire Bull Terrier. <i>Journal of the South African Veterinary Association</i>, http://hdl.handle.net/11427/29070 | en_ZA |
| dc.identifier.chicagocitation | Böhm, Marlies, Howard Henderson, Henriette van der Zwan, and Sandra Basson "L-2 hydroxyglutaric aciduria in a South African Staffordshire Bull Terrier." <i>Journal of the South African Veterinary Association</i> (2014) http://hdl.handle.net/11427/29070 | en_ZA |
| dc.identifier.citation | Bóhm, M., Henderson, H., van der Zwan, H., & Basson, S. (2014). L-2 hydroxyglutaric aciduria in a South African Staffordshire Bull Terrier. Journal of the South African Veterinary Association, 85(1), 01-05. | |
| dc.identifier.ris | TY - AU - Böhm, Marlies AU - Henderson, Howard AU - van der Zwan, Henriette AU - Basson, Sandra AB - L-2 hydroxyglutaric aciduria is an autosomal recessive error of metabolism that manifests as an encephalopathy. The most common presenting signs are seizures, tremors, ataxia and/ or dementia. Some affected dogs show only subtle behavioural changes. Amongst canines, the condition has been best described in Staffordshire Bull Terriers. Although this is the first reported case in South Africa, at least three other affected dogs have been indentified by polmerase chain reaction (PCR) in this country. Affected dogs have normal haematology, serum biochemistry and routine urine analysis. This report discusses the advantages and limitations of the three main diagnostic modalities, namely: magnetic resonance imaging, urine gas chromatography-mass spectrometry and genetic testing. The aim of this report is to increase awareness of the condition, assist diagnosis in encephalopathic dogs and improve detection of carriers amongst breeding stock. DA - 2014 DB - OpenUCT DP - University of Cape Town J1 - Journal of the South African Veterinary Association LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - L-2 hydroxyglutaric aciduria in a South African Staffordshire Bull Terrier TI - L-2 hydroxyglutaric aciduria in a South African Staffordshire Bull Terrier UR - http://hdl.handle.net/11427/29070 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/29070 | |
| dc.identifier.vancouvercitation | Böhm M, Henderson H, van der Zwan H, Basson S. L-2 hydroxyglutaric aciduria in a South African Staffordshire Bull Terrier. Journal of the South African Veterinary Association. 2014; http://hdl.handle.net/11427/29070. | en_ZA |
| dc.language.iso | eng | |
| dc.publisher.department | Department of Clinical Laboratory Sciences | |
| dc.publisher.faculty | Faculty of Health Sciences | |
| dc.publisher.institution | University of Cape Town | |
| dc.source | Journal of the South African Veterinary Association | |
| dc.source.uri | https://jsava.co.za/index.php/jsava | |
| dc.subject.other | Staffordshire Bull Terriers (SBT) | |
| dc.subject.other | L-2 hydroxyglutaric aciduria (L2-HGAU) | |
| dc.title | L-2 hydroxyglutaric aciduria in a South African Staffordshire Bull Terrier | |
| dc.type | Journal Article | |
| uct.type.filetype | Text | |
| uct.type.filetype | Image |