The immunological response to syphilis differs by HIV status; a prospective observational cohort study

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dc.contributor.authorKenyon, Chris
dc.contributor.authorOsbak, Kara Krista
dc.contributor.authorCrucitti, Tania
dc.contributor.authorKestens, Luc
dc.date.accessioned2021-10-08T06:20:31Z
dc.date.available2021-10-08T06:20:31Z
dc.date.issued2017
dc.description.abstractBACKGROUND: It is not known if there is a difference in the immune response to syphilis between HIV-infected and uninfected individuals. METHODS: We prospectively recruited all patients with a new diagnosis of syphilis and tested their plasma for IFNα, IFNγ, IL-1β, IL-12p40, IL-12p70, IP-10, MCP-1, MIP-1α, MIP-1β, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10 and IL-17A at baseline pre-treatment and 6 months following therapy. RESULTS: A total of 79 HIV-infected [44 primary/secondary syphilis (PSS) and 35 latent syphilis (LS)] and 12 HIV-uninfected (10 PSS and 2 LS) cases of syphilis and 30 HIV-infected controls were included in the study. At the baseline visit, compared to the control group, concentrations of IL-10 were significantly elevated in the HIV-infected and uninfected groups. The level of IL-10 was significantly higher in the HIV-infected compared to the HIV-uninfected PSS group (25.3 pg/mL (IQR, 4.56-41.76) vs 2.73 pg/mL (IQR, 1.55-9.02), P = 0.0192). In the HIV-infected PSS group (but not the HIV-infected LS or HIV-uninfected PSS groups) the IP-10, MIP-1b, IL-6 and IL-8 were raised compared to the controls. IL-10 levels decreased but did not return to control baseline values by 6 months in HIV infected PSS and LS and HIV uninfected PSS. CONCLUSION: PSS and LS in HIV-infected individuals is characterized by an increase in inflammatory and anti-inflammatory cytokines such as IL-10. The increase of IL-10 is greater in HIV-infected than uninfected individuals. Further work is required to ascertain if this is part of an immunological profile that correlates with adverse outcomes such as serofast syphilis and neurosyphilis, in HIV-infected individuals.
dc.identifier.apacitationKenyon, C., Osbak, K. K., Crucitti, T., & Kestens, L. (2017). The immunological response to syphilis differs by HIV status; a prospective observational cohort study. <i>BMC Infectious Diseases</i>, 17(1), 174 - 177. http://hdl.handle.net/11427/34296en_ZA
dc.identifier.chicagocitationKenyon, Chris, Kara Krista Osbak, Tania Crucitti, and Luc Kestens "The immunological response to syphilis differs by HIV status; a prospective observational cohort study." <i>BMC Infectious Diseases</i> 17, 1. (2017): 174 - 177. http://hdl.handle.net/11427/34296en_ZA
dc.identifier.citationKenyon, C., Osbak, K.K., Crucitti, T. & Kestens, L. 2017. The immunological response to syphilis differs by HIV status; a prospective observational cohort study. <i>BMC Infectious Diseases.</i> 17(1):174 - 177. http://hdl.handle.net/11427/34296en_ZA
dc.identifier.issn1471-2334
dc.identifier.ris TY - Journal Article AU - Kenyon, Chris AU - Osbak, Kara Krista AU - Crucitti, Tania AU - Kestens, Luc AB - BACKGROUND: It is not known if there is a difference in the immune response to syphilis between HIV-infected and uninfected individuals. METHODS: We prospectively recruited all patients with a new diagnosis of syphilis and tested their plasma for IFNα, IFNγ, IL-1β, IL-12p40, IL-12p70, IP-10, MCP-1, MIP-1α, MIP-1β, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10 and IL-17A at baseline pre-treatment and 6 months following therapy. RESULTS: A total of 79 HIV-infected [44 primary/secondary syphilis (PSS) and 35 latent syphilis (LS)] and 12 HIV-uninfected (10 PSS and 2 LS) cases of syphilis and 30 HIV-infected controls were included in the study. At the baseline visit, compared to the control group, concentrations of IL-10 were significantly elevated in the HIV-infected and uninfected groups. The level of IL-10 was significantly higher in the HIV-infected compared to the HIV-uninfected PSS group (25.3 pg/mL (IQR, 4.56-41.76) vs 2.73 pg/mL (IQR, 1.55-9.02), P = 0.0192). In the HIV-infected PSS group (but not the HIV-infected LS or HIV-uninfected PSS groups) the IP-10, MIP-1b, IL-6 and IL-8 were raised compared to the controls. IL-10 levels decreased but did not return to control baseline values by 6 months in HIV infected PSS and LS and HIV uninfected PSS. CONCLUSION: PSS and LS in HIV-infected individuals is characterized by an increase in inflammatory and anti-inflammatory cytokines such as IL-10. The increase of IL-10 is greater in HIV-infected than uninfected individuals. Further work is required to ascertain if this is part of an immunological profile that correlates with adverse outcomes such as serofast syphilis and neurosyphilis, in HIV-infected individuals. DA - 2017 DB - OpenUCT DP - University of Cape Town IS - 1 J1 - BMC Infectious Diseases LK - https://open.uct.ac.za PY - 2017 SM - 1471-2334 T1 - The immunological response to syphilis differs by HIV status; a prospective observational cohort study TI - The immunological response to syphilis differs by HIV status; a prospective observational cohort study UR - http://hdl.handle.net/11427/34296 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34296
dc.identifier.vancouvercitationKenyon C, Osbak KK, Crucitti T, Kestens L. The immunological response to syphilis differs by HIV status; a prospective observational cohort study. BMC Infectious Diseases. 2017;17(1):174 - 177. http://hdl.handle.net/11427/34296.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Infectious Disease and HIV Med
dc.publisher.facultyFaculty of Health Sciences
dc.sourceBMC Infectious Diseases
dc.source.journalissue1
dc.source.journalvolume17
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.1186/s12879-017-2201-7
dc.subject.otherImmune response
dc.subject.otherSyphilis
dc.subject.otherMethods
dc.subject.otherPatients
dc.subject.otherDiagnosis
dc.subject.otherPlasma
dc.subject.otherIP-10
dc.subject.otherIL-4
dc.subject.otherIL-5
dc.subject.otherIL-6
dc.subject.otherIL-7
dc.subject.otherIL-8
dc.subject.otherIL-10
dc.subject.otherTherapy
dc.subject.otherLatent
dc.subject.otherControl
dc.subject.otherConcentration
dc.subject.otherHIV
dc.subject.otherCytokines
dc.subject.otherCytokine
dc.subject.otherOutcome
dc.subject.otherNeurosyphilis
dc.subject.otherArticle-E
dc.titleThe immunological response to syphilis differs by HIV status; a prospective observational cohort study
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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