Connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing

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dc.contributor.advisorMeintjes, Ernesta Men_ZA
dc.contributor.authorHerron, Robynen_ZA
dc.date.accessioned2014-07-28T18:16:43Z
dc.date.available2014-07-28T18:16:43Z
dc.date.issued2008en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references (leaves 84-91).
dc.description.abstractMaternal drinking during pregnancy is a significant problem in the Western Cape, South Africa, with an accompanying high incidence of children diagnosed with foetal alcohol spectrum disorder (FASD). Little is known about the neural correlates governing the disorder that manifest as behavioural abnormalities and cognitive impairments, particularly in arithmethic calculation, repeatedly reported in affected children. The effect of prenatal alcohol exposure on number processing in children was investigated in a functional magnetic resonance imaging (fMRI) study (Meintjes et al., 2007). The results indicate significant differences in activation between alcohol-exposed and non-exposed control children during Exact Addition and Proximity Judgement tasks. This raised the question of whether the groups of children differ in functional connectivity during the number processing tasks. Therefore, the objective of this study was to analyse connectivity between functionally specialised brain areas in the previously collected fMRI data. The fMRI data of 14 controls and 7 alcohol-exposed children for Exact Addition and 15 controls and 9 alcohol-exposed children for Proximity Judgement was available for analysis. A primary aim was to determine normal functional connectivity in control children during number processing and a secondary aim, to investigate any differences in functional connectivity in children with FASD.en_ZA
dc.identifier.apacitationHerron, R. (2008). <i>Connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Biomedical Engineering. Retrieved from http://hdl.handle.net/11427/3244en_ZA
dc.identifier.chicagocitationHerron, Robyn. <i>"Connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Biomedical Engineering, 2008. http://hdl.handle.net/11427/3244en_ZA
dc.identifier.citationHerron, R. 2008. Connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Herron, Robyn AB - Maternal drinking during pregnancy is a significant problem in the Western Cape, South Africa, with an accompanying high incidence of children diagnosed with foetal alcohol spectrum disorder (FASD). Little is known about the neural correlates governing the disorder that manifest as behavioural abnormalities and cognitive impairments, particularly in arithmethic calculation, repeatedly reported in affected children. The effect of prenatal alcohol exposure on number processing in children was investigated in a functional magnetic resonance imaging (fMRI) study (Meintjes et al., 2007). The results indicate significant differences in activation between alcohol-exposed and non-exposed control children during Exact Addition and Proximity Judgement tasks. This raised the question of whether the groups of children differ in functional connectivity during the number processing tasks. Therefore, the objective of this study was to analyse connectivity between functionally specialised brain areas in the previously collected fMRI data. The fMRI data of 14 controls and 7 alcohol-exposed children for Exact Addition and 15 controls and 9 alcohol-exposed children for Proximity Judgement was available for analysis. A primary aim was to determine normal functional connectivity in control children during number processing and a secondary aim, to investigate any differences in functional connectivity in children with FASD. DA - 2008 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing TI - Connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing UR - http://hdl.handle.net/11427/3244 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3244
dc.identifier.vancouvercitationHerron R. Connectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processing. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Biomedical Engineering, 2008 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3244en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Biomedical Engineeringen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherBiomedical Engineeringen_ZA
dc.titleConnectivity analysis of brain function in children with foetal alcohol spectrum disorder and control children during number processingen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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