Socio-behaviour challenges to phase III HIV vaccine trials in sub-Saharan Africa

dc.contributor.authorSmit, Joalida
dc.contributor.authorMiddelkoop, Keren
dc.contributor.authorMyer, Landon
dc.contributor.authorLindegger, Graham
dc.contributor.authorSwartz, Leslie
dc.contributor.authorSeedat, Soraya
dc.contributor.authorTucker, Tim
dc.contributor.authorWood, Robin
dc.contributor.authorBekker, Linda-Gail
dc.contributor.authorStein, Dan J
dc.date.accessioned2017-11-24T07:05:36Z
dc.date.available2017-11-24T07:05:36Z
dc.date.issued2005
dc.date.updated2017-11-08T08:58:59Z
dc.description.abstractBackground: A number of countries in sub-Saharan Africa are preparing for HIV vaccine efficacy trials. Social and behavioural factors related to HIV transmission require examination in each setting where these trials are considered. As part of this, several countries have also recently begun preparatory research investigating relevant social and behavioural issues. There is a need for a review of the literature to help focus such research efforts in Sub-Saharan Africa. Objective: To examine key social and behavioural issues that may impact on the conduct of HIV vaccine efficacy trials in sub-Saharan Africa. Design: Literature review Methods: Major databases (PubMed, PsychInfo, EBSCOhost, and AIDSline) were searched for literature that discussed social and behavioural issues related to HIV vaccine trials. Three areas are highlighted as being particularly significant for HIV vaccine research: (1) willingness to participate in future HIV vaccine efficacy trials, (2) retention of participants in studies, and (3) sexual risk reporting during trials. For each of these topics, major findings from both developed and developing countries are described and avenues for further research are discussed. Results: There are few data from Sub-Saharan Africa regarding willingness to participate in HIV vaccine trials. Data on participant retention rates varies widely, and maintaining large cohorts of individuals within Phase III trials presents an important challenge. In addition, the possible impact of trial participation on sexual disinhibition, and response bias on sexual risk-reporting remain as issues for HIV vaccine trials in African contexts. Conclusions: Social and behavioural research forms an important part of preparations for HIV vaccine efficacy trials, and there is a clear need for more research of this type in Sub-Saharan Africa. Innovative approaches are required to address issues such as willingness to participate in vaccine research, participant retention during efficacy trials, and the accurate reporting by participants of sexual risk behaviours.
dc.identifier.apacitationSmit, J., Middelkoop, K., Myer, L., Lindegger, G., Swartz, L., Seedat, S., ... Stein, D. J. (2005). Socio-behaviour challenges to phase III HIV vaccine trials in sub-Saharan Africa. <i>African Health Sciences</i>, http://hdl.handle.net/11427/26420en_ZA
dc.identifier.chicagocitationSmit, Joalida, Keren Middelkoop, Landon Myer, Graham Lindegger, Leslie Swartz, Soraya Seedat, Tim Tucker, Robin Wood, Linda-Gail Bekker, and Dan J Stein "Socio-behaviour challenges to phase III HIV vaccine trials in sub-Saharan Africa." <i>African Health Sciences</i> (2005) http://hdl.handle.net/11427/26420en_ZA
dc.identifier.citationSmit, J., Middelkoop, K., Myer, L., Lindegger, G., Swartz, L., Seedat, S., ... & Stein, D. J. (2005). Socio-behaviour challenges to phase III HIV vaccine trials in Sub-Saharan Africa. African health sciences, 5(3), 198-206.
dc.identifier.ris TY - Journal Article AU - Smit, Joalida AU - Middelkoop, Keren AU - Myer, Landon AU - Lindegger, Graham AU - Swartz, Leslie AU - Seedat, Soraya AU - Tucker, Tim AU - Wood, Robin AU - Bekker, Linda-Gail AU - Stein, Dan J AB - Background: A number of countries in sub-Saharan Africa are preparing for HIV vaccine efficacy trials. Social and behavioural factors related to HIV transmission require examination in each setting where these trials are considered. As part of this, several countries have also recently begun preparatory research investigating relevant social and behavioural issues. There is a need for a review of the literature to help focus such research efforts in Sub-Saharan Africa. Objective: To examine key social and behavioural issues that may impact on the conduct of HIV vaccine efficacy trials in sub-Saharan Africa. Design: Literature review Methods: Major databases (PubMed, PsychInfo, EBSCOhost, and AIDSline) were searched for literature that discussed social and behavioural issues related to HIV vaccine trials. Three areas are highlighted as being particularly significant for HIV vaccine research: (1) willingness to participate in future HIV vaccine efficacy trials, (2) retention of participants in studies, and (3) sexual risk reporting during trials. For each of these topics, major findings from both developed and developing countries are described and avenues for further research are discussed. Results: There are few data from Sub-Saharan Africa regarding willingness to participate in HIV vaccine trials. Data on participant retention rates varies widely, and maintaining large cohorts of individuals within Phase III trials presents an important challenge. In addition, the possible impact of trial participation on sexual disinhibition, and response bias on sexual risk-reporting remain as issues for HIV vaccine trials in African contexts. Conclusions: Social and behavioural research forms an important part of preparations for HIV vaccine efficacy trials, and there is a clear need for more research of this type in Sub-Saharan Africa. Innovative approaches are required to address issues such as willingness to participate in vaccine research, participant retention during efficacy trials, and the accurate reporting by participants of sexual risk behaviours. DA - 2005 DB - OpenUCT DP - University of Cape Town J1 - African Health Sciences LK - https://open.uct.ac.za PB - University of Cape Town PY - 2005 T1 - Socio-behaviour challenges to phase III HIV vaccine trials in sub-Saharan Africa TI - Socio-behaviour challenges to phase III HIV vaccine trials in sub-Saharan Africa UR - http://hdl.handle.net/11427/26420 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/26420
dc.identifier.vancouvercitationSmit J, Middelkoop K, Myer L, Lindegger G, Swartz L, Seedat S, et al. Socio-behaviour challenges to phase III HIV vaccine trials in sub-Saharan Africa. African Health Sciences. 2005; http://hdl.handle.net/11427/26420.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.sourceAfrican Health Sciences
dc.source.urihttps://www.ajol.info/index.php/ahs
dc.subject.otherAfrica
dc.subject.otherHIV
dc.subject.othervaccines
dc.titleSocio-behaviour challenges to phase III HIV vaccine trials in sub-Saharan Africa
dc.typeJournal Article
uct.type.filetypeText
uct.type.filetypeImage
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