The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs
| dc.contributor.advisor | Caira, Mino R | |
| dc.contributor.advisor | Nassimbeni, Luigi R | |
| dc.contributor.author | Brown, Gavin Robert | |
| dc.date.accessioned | 2017-01-26T06:58:47Z | |
| dc.date.available | 2017-01-26T06:58:47Z | |
| dc.date.issued | 1997 | |
| dc.date.updated | 2016-11-22T09:12:07Z | |
| dc.description.abstract | The cyclodextrins and their derivatives have been utilised as complexing agents for a wide range of pharmaceutical compounds, through their ability to include small molecular weight molecules inside an annular cavity formed by linked glucose residues of varying number. The non-steroidal anti-inflammatory drugs (NSAIDs), a group of agents that share a similar therapeutic effect in the management of inflammatory processes in the body, have been studied as guest molecules for inclusion in cyclodextrins, due to a number of potential advantages that are conferred by complexation, such as improved bioavailability, modified side-effect profiles and the control of drug release from novel formulations. This study has tested a number of commonly used NSAIDs belonging to certain structural groups, together with a number of cyclodextrins and their derivatives, and attempts have been made to prepare complexes in the solid state and characterise them using physicochemical methods. The cyclodextrins used were native seven' and eight-membered β- and y-cyclodextrin and two methylated derivatives of β-cyclodextrin, namely heptakis(2,6-di-0-methyl)-β-cyclodextrin and heptakis(2,3,6- tri-O-methyl)-β-cyclodextrin, abbreviated as DIMES and TRIMEB respectively. NSAIDs belonging to the salicylate, fenamate, profen, oxicam and indene structural groups were used. These included diflunisal, mefenamic acid, niflumic acid, tolfenamic acid, flufenamic acid, ibuprofen, ketoprofen, piroxicam, tenoxicam, indomethacin and sulindac. | |
| dc.identifier.apacitation | Brown, G. R. (1997). <i>The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs</i>. (). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/23177 | en_ZA |
| dc.identifier.chicagocitation | Brown, Gavin Robert. <i>"The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs."</i> ., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1997. http://hdl.handle.net/11427/23177 | en_ZA |
| dc.identifier.citation | Brown, G. 1997. The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs. University of Cape Town. | en_ZA |
| dc.identifier.ris | TY - Thesis / Dissertation AU - Brown, Gavin Robert AB - The cyclodextrins and their derivatives have been utilised as complexing agents for a wide range of pharmaceutical compounds, through their ability to include small molecular weight molecules inside an annular cavity formed by linked glucose residues of varying number. The non-steroidal anti-inflammatory drugs (NSAIDs), a group of agents that share a similar therapeutic effect in the management of inflammatory processes in the body, have been studied as guest molecules for inclusion in cyclodextrins, due to a number of potential advantages that are conferred by complexation, such as improved bioavailability, modified side-effect profiles and the control of drug release from novel formulations. This study has tested a number of commonly used NSAIDs belonging to certain structural groups, together with a number of cyclodextrins and their derivatives, and attempts have been made to prepare complexes in the solid state and characterise them using physicochemical methods. The cyclodextrins used were native seven' and eight-membered β- and y-cyclodextrin and two methylated derivatives of β-cyclodextrin, namely heptakis(2,6-di-0-methyl)-β-cyclodextrin and heptakis(2,3,6- tri-O-methyl)-β-cyclodextrin, abbreviated as DIMES and TRIMEB respectively. NSAIDs belonging to the salicylate, fenamate, profen, oxicam and indene structural groups were used. These included diflunisal, mefenamic acid, niflumic acid, tolfenamic acid, flufenamic acid, ibuprofen, ketoprofen, piroxicam, tenoxicam, indomethacin and sulindac. DA - 1997 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1997 T1 - The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs TI - The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs UR - http://hdl.handle.net/11427/23177 ER - | en_ZA |
| dc.identifier.uri | http://hdl.handle.net/11427/23177 | |
| dc.identifier.vancouvercitation | Brown GR. The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs. []. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1997 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/23177 | en_ZA |
| dc.language.iso | eng | |
| dc.publisher.department | Department of Chemistry | en_ZA |
| dc.publisher.faculty | Faculty of Science | en_ZA |
| dc.publisher.institution | University of Cape Town | |
| dc.subject.other | Chemistry | |
| dc.title | The physicochemical characterisation of cyclodextrin inclusion compounds with non-steroidal anti-inflammatory drugs | |
| dc.type | Thesis |