Quantifying right ventricular motion and strain using 3D cine DENSE MRI

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dc.contributor.authorAuger, Danielen_ZA
dc.contributor.authorZhong, Xiaodongen_ZA
dc.contributor.authorMeintjes, Ernesta Men_ZA
dc.contributor.authorEpstein, Frederick Hen_ZA
dc.contributor.authorSpottiswoode, Bruce Sen_ZA
dc.date.accessioned2015-11-11T12:01:16Z
dc.date.available2015-11-11T12:01:16Z
dc.date.issued2011en_ZA
dc.description.abstractBackground: The RV is difficult to image because of its thin wall, asymmetric geometry and complex motion. DENSE is a quantitative MRI technique for measuring myocardial displacement and strain at high spatial and temporal resolutions [1,2]. DENSE encodes tissue displacement directly into the image phase, allowing for the direct extraction of motion data at a pixel resolution. A free-breathing navigator-gated spiral 3D cine DENSE sequence was recently developed [3], providing an MRI technique which is well suited to quantifying RV mechanics. Methods: Whole heart 3D cine DENSE data were acquired from two normal volunteers, after informed consent was obtained and in accordance with protocols approved by the University of Virginia institutional review board. The endocardial and epicardial contours were manually delineated to identify the myocardium from surrounding anatomical structures. A 3D spatiotemporal phase unwrapping algorithm was used to remove phase aliasing [4], and 3D Lagrangian displacement fields were derived for all cardiac phases. Midline contours were calculated from the epicardial and endocardial contours, and tissue tracking seed points were defined at pixel spaced intervals. A 3D tracking algorithm was implemented as a direct extension of the 2D tracking algorithm presented in [4], producing midline motion trajectories from which strain was calculated. Tangential 1D strain was calculated in the longitudinal and circumferential cardiac directions. Strain time curves are computed representing the free wall of the RV. Results: Figure 1 illustrates the RV free wall mean tangential 1D strain time curves for approximately 3/4 of the cardiac cycle over the apical-mid section of the heart for one volunteer. Results show measurements ranging between -0.1 and -0.25, and further illustrate a greater displacement in the longitudinal direction. Results compare favorably with studies using myocardial tagging and DENSE[5,6].en_ZA
dc.identifier.apacitationAuger, D., Zhong, X., Meintjes, E. M., Epstein, F. H., & Spottiswoode, B. S. (2011). Quantifying right ventricular motion and strain using 3D cine DENSE MRI. <i>Journal of Cardiovascular Magnetic Resonance</i>, http://hdl.handle.net/11427/14887en_ZA
dc.identifier.chicagocitationAuger, Daniel, Xiaodong Zhong, Ernesta M Meintjes, Frederick H Epstein, and Bruce S Spottiswoode "Quantifying right ventricular motion and strain using 3D cine DENSE MRI." <i>Journal of Cardiovascular Magnetic Resonance</i> (2011) http://hdl.handle.net/11427/14887en_ZA
dc.identifier.citationAuger, D. A., Zhong, X., Meintjes, E. M., Epstein, F. H., & Spottiswoode, B. S. (2011). Quantifying right ventricular motion and strain using 3D cine DENSE MRI. Journal of Cardiovascular Magnetic Resonance, 13(1), 1-2.en_ZA
dc.identifier.ris TY - Journal Article AU - Auger, Daniel AU - Zhong, Xiaodong AU - Meintjes, Ernesta M AU - Epstein, Frederick H AU - Spottiswoode, Bruce S AB - Background: The RV is difficult to image because of its thin wall, asymmetric geometry and complex motion. DENSE is a quantitative MRI technique for measuring myocardial displacement and strain at high spatial and temporal resolutions [1,2]. DENSE encodes tissue displacement directly into the image phase, allowing for the direct extraction of motion data at a pixel resolution. A free-breathing navigator-gated spiral 3D cine DENSE sequence was recently developed [3], providing an MRI technique which is well suited to quantifying RV mechanics. Methods: Whole heart 3D cine DENSE data were acquired from two normal volunteers, after informed consent was obtained and in accordance with protocols approved by the University of Virginia institutional review board. The endocardial and epicardial contours were manually delineated to identify the myocardium from surrounding anatomical structures. A 3D spatiotemporal phase unwrapping algorithm was used to remove phase aliasing [4], and 3D Lagrangian displacement fields were derived for all cardiac phases. Midline contours were calculated from the epicardial and endocardial contours, and tissue tracking seed points were defined at pixel spaced intervals. A 3D tracking algorithm was implemented as a direct extension of the 2D tracking algorithm presented in [4], producing midline motion trajectories from which strain was calculated. Tangential 1D strain was calculated in the longitudinal and circumferential cardiac directions. Strain time curves are computed representing the free wall of the RV. Results: Figure 1 illustrates the RV free wall mean tangential 1D strain time curves for approximately 3/4 of the cardiac cycle over the apical-mid section of the heart for one volunteer. Results show measurements ranging between -0.1 and -0.25, and further illustrate a greater displacement in the longitudinal direction. Results compare favorably with studies using myocardial tagging and DENSE[5,6]. DA - 2011 DB - OpenUCT DO - 10.1186/1532-429X-13-S1-M3 DP - University of Cape Town J1 - Journal of Cardiovascular Magnetic Resonance LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Quantifying right ventricular motion and strain using 3D cine DENSE MRI TI - Quantifying right ventricular motion and strain using 3D cine DENSE MRI UR - http://hdl.handle.net/11427/14887 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14887
dc.identifier.urihttp://dx.doi.org/10.1186/1532-429X-13-S1-M3
dc.identifier.vancouvercitationAuger D, Zhong X, Meintjes EM, Epstein FH, Spottiswoode BS. Quantifying right ventricular motion and strain using 3D cine DENSE MRI. Journal of Cardiovascular Magnetic Resonance. 2011; http://hdl.handle.net/11427/14887.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Human Biologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2011 Auger et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceJournal of Cardiovascular Magnetic Resonanceen_ZA
dc.source.urihttp://www.jcmr-online.com/en_ZA
dc.subject.otherCine Denseen_ZA
dc.subject.otherTissue Trackingen_ZA
dc.subject.otherDense MRIen_ZA
dc.subject.otherTracking Algorithmen_ZA
dc.subject.otherMotion Trajectoryen_ZA
dc.subject.otherMyocardial Displacementen_ZA
dc.subject.other3d Cineen_ZA
dc.subject.otherSpatiotemporal Phaseen_ZA
dc.subject.otherRV Mechanicen_ZA
dc.subject.otherLagrangian Displacementen_ZA
dc.titleQuantifying right ventricular motion and strain using 3D cine DENSE MRIen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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