Consumption of Monounsaturated Fatty Acids Is Associated with Improved Cardiometabolic Outcomes in Four African-Origin Populations Spanning the Epidemiologic Transition

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dc.contributor.authorMehta, Supal
dc.contributor.authorRuth Dugas, Lara
dc.contributor.authorChoo-Kang, Candice
dc.contributor.authorBovet, Pascal
dc.contributor.authorForrester, Terrence
dc.contributor.authorBedu-Addo, Kweku
dc.contributor.authorLambert, Estelle Vicki
dc.contributor.authorPlange-Rhule, Jacob
dc.contributor.authorRiesen, Walter
dc.contributor.authorKorte, Wolfgang
dc.contributor.authorLuke, Amy
dc.date.accessioned2021-10-05T16:10:35Z
dc.date.available2021-10-05T16:10:35Z
dc.date.issued2021-07-16
dc.date.updated2021-08-06T15:19:07Z
dc.description.abstractLong-chain omega-3 PUFAs, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are of increasing interest because of their favorable effect on cardiometabolic risk. This study explores the association between omega 6 and 3 fatty acids intake and cardiometabolic risk in four African-origin populations spanning the epidemiological transition. Data are obtained from a cohort of 2500 adults aged 25–45 enrolled in the Modeling the Epidemiologic Transition Study (METS), from the US, Ghana, Jamaica, and the Seychelles. Dietary intake was measured using two 24 h recalls from the Nutrient Data System for Research (NDSR). The prevalence of cardiometabolic risk was analyzed by comparing the lowest and highest quartile of omega-3 (EPA+ DHA) consumption and by comparing participants who consumed a ratio of arachidonic acid (AA)/EPA + DHA ≤ 4:1 and >4:1. Data were analyzed using multiple variable logistic regression adjusted for age, gender, activity, calorie intake, alcohol intake, and smoking status. The lowest quartile of EPA + DHA intake is associated with cardiometabolic risk 2.16 (1.45, 3.2), inflammation 1.59 (1.17, 2.16), and obesity 2.06 (1.50, 2.82). Additionally, consuming an AA/EPA + DHA ratio of >4:1 is also associated with cardiometabolic risk 1.80 (1.24, 2.60), inflammation 1.47 (1.06, 2.03), and obesity 1.72 (1.25, 2.39). Our findings corroborate previous research supporting a beneficial role for monounsaturated fatty acids in reducing cardiometabolic risk.
dc.identifierdoi: 10.3390/nu13072442
dc.identifier.apacitationMehta, S., Ruth Dugas, L., Choo-Kang, C., Bovet, P., Forrester, T., Bedu-Addo, K., ... Luke, A. (2021). Consumption of Monounsaturated Fatty Acids Is Associated with Improved Cardiometabolic Outcomes in Four African-Origin Populations Spanning the Epidemiologic Transition. <i>Nutrients</i>,(13), http://hdl.handle.net/11427/34092en_ZA
dc.identifier.chicagocitationMehta, Supal, Lara Ruth Dugas, Candice Choo-Kang, Pascal Bovet, Terrence Forrester, Kweku Bedu-Addo, Estelle Vicki Lambert, et al "Consumption of Monounsaturated Fatty Acids Is Associated with Improved Cardiometabolic Outcomes in Four African-Origin Populations Spanning the Epidemiologic Transition." <i>Nutrients</i> 13. (2021) http://hdl.handle.net/11427/34092en_ZA
dc.identifier.citationMehta, S., Ruth Dugas, L., Choo-Kang, C., Bovet, P., Forrester, T., Bedu-Addo, K., Lambert, E.V. & Plange-Rhule, J. et al. 2021. Consumption of Monounsaturated Fatty Acids Is Associated with Improved Cardiometabolic Outcomes in Four African-Origin Populations Spanning the Epidemiologic Transition. <i>Nutrients.</i>(13) http://hdl.handle.net/11427/34092en_ZA
dc.identifier.ris TY - Journal Article AU - Mehta, Supal AU - Ruth Dugas, Lara AU - Choo-Kang, Candice AU - Bovet, Pascal AU - Forrester, Terrence AU - Bedu-Addo, Kweku AU - Lambert, Estelle Vicki AU - Plange-Rhule, Jacob AU - Riesen, Walter AU - Korte, Wolfgang AU - Luke, Amy AB - Long-chain omega-3 PUFAs, specifically eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are of increasing interest because of their favorable effect on cardiometabolic risk. This study explores the association between omega 6 and 3 fatty acids intake and cardiometabolic risk in four African-origin populations spanning the epidemiological transition. Data are obtained from a cohort of 2500 adults aged 25–45 enrolled in the Modeling the Epidemiologic Transition Study (METS), from the US, Ghana, Jamaica, and the Seychelles. Dietary intake was measured using two 24 h recalls from the Nutrient Data System for Research (NDSR). The prevalence of cardiometabolic risk was analyzed by comparing the lowest and highest quartile of omega-3 (EPA+ DHA) consumption and by comparing participants who consumed a ratio of arachidonic acid (AA)/EPA + DHA ≤ 4:1 and >4:1. Data were analyzed using multiple variable logistic regression adjusted for age, gender, activity, calorie intake, alcohol intake, and smoking status. The lowest quartile of EPA + DHA intake is associated with cardiometabolic risk 2.16 (1.45, 3.2), inflammation 1.59 (1.17, 2.16), and obesity 2.06 (1.50, 2.82). Additionally, consuming an AA/EPA + DHA ratio of >4:1 is also associated with cardiometabolic risk 1.80 (1.24, 2.60), inflammation 1.47 (1.06, 2.03), and obesity 1.72 (1.25, 2.39). Our findings corroborate previous research supporting a beneficial role for monounsaturated fatty acids in reducing cardiometabolic risk. DA - 2021-07-16 DB - OpenUCT DP - University of Cape Town IS - 13 J1 - Nutrients LK - https://open.uct.ac.za PY - 2021 T1 - Consumption of Monounsaturated Fatty Acids Is Associated with Improved Cardiometabolic Outcomes in Four African-Origin Populations Spanning the Epidemiologic Transition TI - Consumption of Monounsaturated Fatty Acids Is Associated with Improved Cardiometabolic Outcomes in Four African-Origin Populations Spanning the Epidemiologic Transition UR - http://hdl.handle.net/11427/34092 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34092
dc.identifier.vancouvercitationMehta S, Ruth Dugas L, Choo-Kang C, Bovet P, Forrester T, Bedu-Addo K, et al. Consumption of Monounsaturated Fatty Acids Is Associated with Improved Cardiometabolic Outcomes in Four African-Origin Populations Spanning the Epidemiologic Transition. Nutrients. 2021;(13) http://hdl.handle.net/11427/34092.en_ZA
dc.publisherMultidisciplinary Digital Publishing Institute
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceNutrients
dc.source.journalissue13
dc.source.journalissue7
dc.source.journalissue2442
dc.source.urihttps://www.mdpi.com/journal/nutrients
dc.titleConsumption of Monounsaturated Fatty Acids Is Associated with Improved Cardiometabolic Outcomes in Four African-Origin Populations Spanning the Epidemiologic Transition
dc.typeJournal Article
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