Systematic Reviews

dc.contributor.authorNjau, Bernard
dc.contributor.authorDamian, Damian J
dc.contributor.authorAbdullahi, Leila
dc.contributor.authorBoulle, Andrew
dc.contributor.authorMathews, Catherine
dc.date.accessioned2016-05-23T12:44:58Z
dc.date.available2016-05-23T12:44:58Z
dc.date.issued2016
dc.date.updated2016-05-19T09:24:03Z
dc.description.abstractBackground: HIV is still a global public health problem. More than 75 % of HIV-infected people are in Africa, and most of them are unaware of their HIV status, which is a barrier to accessing antiretroviral treatment. Our review aims, firstly, to determine whether HIV self-testing is an effective method to increase the uptake of testing, the yield of new HIV-positive diagnoses, and the linkage to antiretroviral treatment. Secondly, we aim to review the factors that facilitate or impede the uptake of HIV self-testing. Methods/design: Participants will be adults living in Africa. For the first aim, the intervention will be HIV self-testing either alone or in addition to HIV testing standard of care. The comparison will be HIV testing standard of care. The primary outcomes will be (i) uptake of HIV testing and (ii) yield of new HIV-positive diagnoses. The secondary outcomes will be (a) linkage to antiretroviral (ARV) treatment and (b) incidence of social harms. For the second aim, we will review barriers and facilitators to the uptake of self-testing. We will search PubMed, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, WHOLIS, Africa Wide, and CINAHL for eligible studies from 1998, with no language limits. We will check reference lists of included studies for other eligible reports. Eligible studies will include experimental and observational studies. Two authors will independently screen the search output, select studies, and extract data, resolving discrepancies by consensus and discussion. Two authors will use Cochrane risk of bias tools for experimental studies, the Newcastle-Ottawa Quality Assessment Scale for observational studies, and the Critical Appraisal Skills Programme (CASP) quality assessment tool for qualitative studies. Discussion: Innovative and cost-effective community-based HIV testing strategies, such as self-testing, will contribute to universal coverage of HIV testing.en_ZA
dc.identifier.apacitationNjau, B., Damian, D. J., Abdullahi, L., Boulle, A., & Mathews, C. (2016). Systematic Reviews. <i>Systematic Reviews</i>, http://hdl.handle.net/11427/19793en_ZA
dc.identifier.chicagocitationNjau, Bernard, Damian J Damian, Leila Abdullahi, Andrew Boulle, and Catherine Mathews "Systematic Reviews." <i>Systematic Reviews</i> (2016) http://hdl.handle.net/11427/19793en_ZA
dc.identifier.citationNjau, B., Damian, D. J., Abdullahi, L., Boulle, A., & Mathews, C. (2016). The effects of HIV self-testing on the uptake of HIV testing and linkage to antiretroviral treatment among adults in Africa: a systematic review protocol. Systematic Reviews, 5(1), 1.en_ZA
dc.identifier.issn2046-4053en_ZA
dc.identifier.ris TY - Journal Article AU - Njau, Bernard AU - Damian, Damian J AU - Abdullahi, Leila AU - Boulle, Andrew AU - Mathews, Catherine AB - Background: HIV is still a global public health problem. More than 75 % of HIV-infected people are in Africa, and most of them are unaware of their HIV status, which is a barrier to accessing antiretroviral treatment. Our review aims, firstly, to determine whether HIV self-testing is an effective method to increase the uptake of testing, the yield of new HIV-positive diagnoses, and the linkage to antiretroviral treatment. Secondly, we aim to review the factors that facilitate or impede the uptake of HIV self-testing. Methods/design: Participants will be adults living in Africa. For the first aim, the intervention will be HIV self-testing either alone or in addition to HIV testing standard of care. The comparison will be HIV testing standard of care. The primary outcomes will be (i) uptake of HIV testing and (ii) yield of new HIV-positive diagnoses. The secondary outcomes will be (a) linkage to antiretroviral (ARV) treatment and (b) incidence of social harms. For the second aim, we will review barriers and facilitators to the uptake of self-testing. We will search PubMed, Cochrane Central Register of Controlled Trials, Scopus, Web of Science, WHOLIS, Africa Wide, and CINAHL for eligible studies from 1998, with no language limits. We will check reference lists of included studies for other eligible reports. Eligible studies will include experimental and observational studies. Two authors will independently screen the search output, select studies, and extract data, resolving discrepancies by consensus and discussion. Two authors will use Cochrane risk of bias tools for experimental studies, the Newcastle-Ottawa Quality Assessment Scale for observational studies, and the Critical Appraisal Skills Programme (CASP) quality assessment tool for qualitative studies. Discussion: Innovative and cost-effective community-based HIV testing strategies, such as self-testing, will contribute to universal coverage of HIV testing. DA - 2016 DB - OpenUCT DO - 10.1186/s13643-016-0230-8 DP - University of Cape Town J1 - Systematic Reviews KW - HIV self-testing KW - Uptake KW - Yield KW - Barriers KW - Facilitators KW - Social harms KW - Africa LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 SM - 2046-4053 T1 - Systematic Reviews TI - Systematic Reviews UR - http://hdl.handle.net/11427/19793 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1186/s13643-016-0230-8
dc.identifier.urihttp://hdl.handle.net/11427/19793
dc.identifier.vancouvercitationNjau B, Damian DJ, Abdullahi L, Boulle A, Mathews C. Systematic Reviews. Systematic Reviews. 2016; http://hdl.handle.net/11427/19793.en_ZA
dc.languageengen_ZA
dc.language.rfc3066en
dc.publisherBioMed Centralen_ZA
dc.publisher.departmentDivision of Public Healthen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsCreative Commons Attribution 4.0 International (CC BY 4.0)*
dc.rights.holderNjau et al.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_ZA
dc.sourceSystematic Reviewsen_ZA
dc.source.urihttp://systematicreviewsjournal.biomedcentral.com/
dc.subjectHIV self-testing
dc.subjectUptake
dc.subjectYield
dc.subjectBarriers
dc.subjectFacilitators
dc.subjectSocial harms
dc.subjectAfrica
dc.titleSystematic Reviewsen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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