The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury

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dc.contributor.advisorHall, Pauline de la Motteen_ZA
dc.contributor.authorLangman, Geralden_ZA
dc.date.accessioned2014-07-28T14:51:42Z
dc.date.available2014-07-28T14:51:42Z
dc.date.issued2001en_ZA
dc.descriptionIncludes bibliographical references.
dc.description.abstractHepatoxicity, especially liver fibrosis. is the major concern with long-term, low-dose oral methotrexate (MTX) therapy for psoriasis. The histological features are nonspecific and may resemble those of nonalcoholic steatohepatitis (NASH). Moreover most of the risk factors of MTX induced liver injury are also associated with NASH. In this study serial liver biopsies of 24 psoriatic patients on lOng-term MTX were investigated to determine whether they had risk factors for NASH and the histological features of a NASH-like pattern of liver injury that could have been contributing to the prevalence and progression of liver injury that occurred while on MTX.en_ZA
dc.identifier.apacitationLangman, G. (2001). <i>The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Anatomical Pathology. Retrieved from http://hdl.handle.net/11427/3082en_ZA
dc.identifier.chicagocitationLangman, Gerald. <i>"The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Anatomical Pathology, 2001. http://hdl.handle.net/11427/3082en_ZA
dc.identifier.citationLangman, G. 2001. The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Langman, Gerald AB - Hepatoxicity, especially liver fibrosis. is the major concern with long-term, low-dose oral methotrexate (MTX) therapy for psoriasis. The histological features are nonspecific and may resemble those of nonalcoholic steatohepatitis (NASH). Moreover most of the risk factors of MTX induced liver injury are also associated with NASH. In this study serial liver biopsies of 24 psoriatic patients on lOng-term MTX were investigated to determine whether they had risk factors for NASH and the histological features of a NASH-like pattern of liver injury that could have been contributing to the prevalence and progression of liver injury that occurred while on MTX. DA - 2001 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2001 T1 - The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury TI - The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury UR - http://hdl.handle.net/11427/3082 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3082
dc.identifier.vancouvercitationLangman G. The role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injury. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Anatomical Pathology, 2001 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3082en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Anatomical Pathologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherAnatomical Pathologyen_ZA
dc.titleThe role of "non-alcoholic steatohepatitis (NASH)" in methotrexate induced liver injuryen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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