A prospective cohort study on ambient air pollution and respiratory morbidities including childhood asthma in adolescents from the western Cape Province: study protocol

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dc.contributor.authorOlaniyan, Toyib
dc.contributor.authorJeebhay, Mohamed
dc.contributor.authorRöösli, Martin
dc.contributor.authorNaidoo, Rajen
dc.contributor.authorBaatjies, Roslynn
dc.contributor.authorKünzil, Nino
dc.contributor.authorTsai, Ming
dc.contributor.authorDavey, Mark
dc.contributor.authorde Hoogh, Kees
dc.contributor.authorBerman, Dilys
dc.contributor.authorParker, Bhawoodien
dc.contributor.authorLeaner, Joy
dc.contributor.authorDalvie, Mohamed A
dc.date.accessioned2017-09-18T06:37:01Z
dc.date.available2017-09-18T06:37:01Z
dc.date.issued2017-09-16
dc.date.updated2017-09-17T03:19:13Z
dc.description.abstractBackground: There is evidence from existing literature that ambient air pollutant exposure in early childhood likely plays an important role in asthma exacerbation and other respiratory symptoms, with greater effect among asthmatic children. However, there is inconclusive evidence on the role of ambient air pollutant exposures in relation to increasing asthma prevalence as well as asthma induction in children. At the population level, little is known about the potential synergistic effects between pollen allergens and air pollutants since this type of association poses challenges in uncontrolled real life settings. In particular, data from sub-Sahara Africa is scarce and virtually absent among populations residing in informal residential settlements. Methods/design: A prospective cohort study of 600 school children residing in four informal settlement areas with varying potential ambient air pollutant exposure levels in the Western Cape in South Africa is carried-out. The study has two follow-up periods of at least six-months apart including an embedded panel study in summer and winter. The exposure assessment component models temporal and spatial variability of air quality in the four study areas over the study duration using land-use regression modelling (LUR). Additionally, daily pollen levels (mould spores, tree, grass and weed pollen) in the study areas are recorded. In the panel study asthma symptoms and serial peak flow measurements is recorded three times daily to determine short-term serial airway changes in relation to varying ambient air quality and pollen over 10-days during winter and summer. The health outcome component of the cohort study include; the presence of asthma using a standardised ISAAC questionnaire, spirometry, fractional exhaled nitric-oxide (FeNO) and the presence of atopy (Phadiatop). Discussion: This research applies state of the art exposure assessment approaches to characterize the effects of ambient air pollutants on childhood respiratory health, with a specific focus on asthma and markers of airway inflammation (FeNO) in South African informal settlement areas by considering also pollen counts and meteorological factors. The study will generate crucial data on air pollution and asthma in low income settings in sub-Sahara Africa that is lacking in the international literature.
dc.identifier.apacitationOlaniyan, T., Jeebhay, M., Röösli, M., Naidoo, R., Baatjies, R., Künzil, N., ... Dalvie, M. A. (2017). A prospective cohort study on ambient air pollution and respiratory morbidities including childhood asthma in adolescents from the western Cape Province: study protocol. <i>BMC Public Health</i>, http://hdl.handle.net/11427/25221en_ZA
dc.identifier.chicagocitationOlaniyan, Toyib, Mohamed Jeebhay, Martin Röösli, Rajen Naidoo, Roslynn Baatjies, Nino Künzil, Ming Tsai, et al "A prospective cohort study on ambient air pollution and respiratory morbidities including childhood asthma in adolescents from the western Cape Province: study protocol." <i>BMC Public Health</i> (2017) http://hdl.handle.net/11427/25221en_ZA
dc.identifier.citationOlaniyan, T., Jeebhay, M., Röösli, M., Naidoo, R., Naidoo, R., Künzil, N., Davey, M., Tsai, M., Hoogh, K., Berman, D., Parker, B., Leaner, J., & Dalvie, M. A. (2017).A prospective cohort study on ambient air pollution and respiratory morbidities including childhood asthma in adolescents from the Western Cape Province: study protocol. BMC Public Health, 17(1):712. DOI: 10.1186/s12889-017-4726-5.
dc.identifier.ris TY - Journal Article AU - Olaniyan, Toyib AU - Jeebhay, Mohamed AU - Röösli, Martin AU - Naidoo, Rajen AU - Baatjies, Roslynn AU - Künzil, Nino AU - Tsai, Ming AU - Davey, Mark AU - de Hoogh, Kees AU - Berman, Dilys AU - Parker, Bhawoodien AU - Leaner, Joy AU - Dalvie, Mohamed A AB - Background: There is evidence from existing literature that ambient air pollutant exposure in early childhood likely plays an important role in asthma exacerbation and other respiratory symptoms, with greater effect among asthmatic children. However, there is inconclusive evidence on the role of ambient air pollutant exposures in relation to increasing asthma prevalence as well as asthma induction in children. At the population level, little is known about the potential synergistic effects between pollen allergens and air pollutants since this type of association poses challenges in uncontrolled real life settings. In particular, data from sub-Sahara Africa is scarce and virtually absent among populations residing in informal residential settlements. Methods/design: A prospective cohort study of 600 school children residing in four informal settlement areas with varying potential ambient air pollutant exposure levels in the Western Cape in South Africa is carried-out. The study has two follow-up periods of at least six-months apart including an embedded panel study in summer and winter. The exposure assessment component models temporal and spatial variability of air quality in the four study areas over the study duration using land-use regression modelling (LUR). Additionally, daily pollen levels (mould spores, tree, grass and weed pollen) in the study areas are recorded. In the panel study asthma symptoms and serial peak flow measurements is recorded three times daily to determine short-term serial airway changes in relation to varying ambient air quality and pollen over 10-days during winter and summer. The health outcome component of the cohort study include; the presence of asthma using a standardised ISAAC questionnaire, spirometry, fractional exhaled nitric-oxide (FeNO) and the presence of atopy (Phadiatop). Discussion: This research applies state of the art exposure assessment approaches to characterize the effects of ambient air pollutants on childhood respiratory health, with a specific focus on asthma and markers of airway inflammation (FeNO) in South African informal settlement areas by considering also pollen counts and meteorological factors. The study will generate crucial data on air pollution and asthma in low income settings in sub-Sahara Africa that is lacking in the international literature. DA - 2017-09-16 DB - OpenUCT DO - 10.1186/s12889-017-4726-5 DP - University of Cape Town J1 - BMC Public Health LK - https://open.uct.ac.za PB - University of Cape Town PY - 2017 T1 - A prospective cohort study on ambient air pollution and respiratory morbidities including childhood asthma in adolescents from the western Cape Province: study protocol TI - A prospective cohort study on ambient air pollution and respiratory morbidities including childhood asthma in adolescents from the western Cape Province: study protocol UR - http://hdl.handle.net/11427/25221 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1186/s12889-017-4726-5
dc.identifier.urihttp://hdl.handle.net/11427/25221
dc.identifier.vancouvercitationOlaniyan T, Jeebhay M, Röösli M, Naidoo R, Baatjies R, Künzil N, et al. A prospective cohort study on ambient air pollution and respiratory morbidities including childhood asthma in adolescents from the western Cape Province: study protocol. BMC Public Health. 2017; http://hdl.handle.net/11427/25221.en_ZA
dc.language.isoen
dc.publisherBioMed Central
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rights.holderThe Author(s).
dc.sourceBMC Public Health
dc.source.urihttps://bmcpublichealth.biomedcentral.com/
dc.subject.otherAmbient air pollution
dc.subject.otherEnvironmental pollution
dc.subject.otherOutdoor air pollution
dc.subject.otherTraffic-related pollutants
dc.subject.otherPollens
dc.subject.otherChildhood asthma
dc.subject.otherRespiratory morbidities
dc.subject.otherAllergic diseases
dc.subject.otherLung function
dc.subject.otherAirway inflammation
dc.titleA prospective cohort study on ambient air pollution and respiratory morbidities including childhood asthma in adolescents from the western Cape Province: study protocol
dc.typeJournal Article
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uct.type.filetypeText
uct.type.filetypeImage
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