Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves

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dc.contributor.advisorLittle, Francescaen_ZA
dc.contributor.advisorBarnes, Karenen_ZA
dc.contributor.authorMauff, Katyaen_ZA
dc.date.accessioned2014-12-31T19:46:06Z
dc.date.available2014-12-31T19:46:06Z
dc.date.issued2011en_ZA
dc.description.abstractThis thesis discusses the techniques involved in the fitting of nonlinear mixed effect (NLME) models. In particular, it looks at the application of these techniques to the analysis of concentration-time data for the aforementioned antimalarial compounds, and details the necessary extensions to the basic modeling process that were required in order to accommodate multiple responses and multiple observation phases (pregnant and postpartum).en_ZA
dc.identifier.apacitationMauff, K. (2011). <i>Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Statistical Sciences. Retrieved from http://hdl.handle.net/11427/10719en_ZA
dc.identifier.chicagocitationMauff, Katya. <i>"Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Statistical Sciences, 2011. http://hdl.handle.net/11427/10719en_ZA
dc.identifier.citationMauff, K. 2011. Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mauff, Katya AB - This thesis discusses the techniques involved in the fitting of nonlinear mixed effect (NLME) models. In particular, it looks at the application of these techniques to the analysis of concentration-time data for the aforementioned antimalarial compounds, and details the necessary extensions to the basic modeling process that were required in order to accommodate multiple responses and multiple observation phases (pregnant and postpartum). DA - 2011 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2011 T1 - Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves TI - Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves UR - http://hdl.handle.net/11427/10719 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/10719
dc.identifier.vancouvercitationMauff K. Multivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curves. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Statistical Sciences, 2011 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/10719en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Statistical Sciencesen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherStatistical Scienceen_ZA
dc.titleMultivariate muti-level non-linear mixed-effect models and their application to the modeling of drug-concentration time curvesen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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