P19-53 LB. Priming with recombinant BCG expressing HIV-1 Gag or RT and boosting with recombinant MVA induces an effective immune response in mice

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dc.contributor.authorStutz, Hen_ZA
dc.contributor.authorPowles, Ren_ZA
dc.contributor.authorShephard, EGen_ZA
dc.contributor.authorWilliamson, Aen_ZA
dc.date.accessioned2015-11-04T11:45:19Z
dc.date.available2015-11-04T11:45:19Z
dc.date.issued2009en_ZA
dc.description.abstractMycobacterium bovis BCG (BCG) has a number of characteristics that give it great potential to act as a vehicle for the delivery of recombinant vaccines. However, its success depends on overcoming the challenges of poor antigen expression levels and genetic instability. Our studies using an optimized mycobacterial shuttle vector which utilizes the Mycobacterium tuberculosis mtrA promoter, induced upon infection of macrophages, and the M. tuberculosis 19 kDa signal sequence may overcome these issues. We have used this system to generate a recombinant BCG (rBCG) expressing HIV-1 subtype C full length Gag or reverse transcriptase (RT).en_ZA
dc.identifier.apacitationStutz, H., Powles, R., Shephard, E., & Williamson, A. (2009). P19-53 LB. Priming with recombinant BCG expressing HIV-1 Gag or RT and boosting with recombinant MVA induces an effective immune response in mice. <i>Retrovirology</i>, http://hdl.handle.net/11427/14656en_ZA
dc.identifier.chicagocitationStutz, H, R Powles, EG Shephard, and A Williamson "P19-53 LB. Priming with recombinant BCG expressing HIV-1 Gag or RT and boosting with recombinant MVA induces an effective immune response in mice." <i>Retrovirology</i> (2009) http://hdl.handle.net/11427/14656en_ZA
dc.identifier.citationStutz, H., Powles, R., Shephard, E. G., & Williamson, A. (2009). P19-53 LB. Priming with recombinant BCG expressing HIV-1 Gag or RT and boosting with recombinant MVA induces an effective immune response in mice. Retrovirology, 6(Suppl 3), P417.en_ZA
dc.identifier.ris TY - Journal Article AU - Stutz, H AU - Powles, R AU - Shephard, EG AU - Williamson, A AB - Mycobacterium bovis BCG (BCG) has a number of characteristics that give it great potential to act as a vehicle for the delivery of recombinant vaccines. However, its success depends on overcoming the challenges of poor antigen expression levels and genetic instability. Our studies using an optimized mycobacterial shuttle vector which utilizes the Mycobacterium tuberculosis mtrA promoter, induced upon infection of macrophages, and the M. tuberculosis 19 kDa signal sequence may overcome these issues. We have used this system to generate a recombinant BCG (rBCG) expressing HIV-1 subtype C full length Gag or reverse transcriptase (RT). DA - 2009 DB - OpenUCT DO - 10.1186/1742-4690-6-S3-P417 DP - University of Cape Town J1 - Retrovirology LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - P19-53 LB. Priming with recombinant BCG expressing HIV-1 Gag or RT and boosting with recombinant MVA induces an effective immune response in mice TI - P19-53 LB. Priming with recombinant BCG expressing HIV-1 Gag or RT and boosting with recombinant MVA induces an effective immune response in mice UR - http://hdl.handle.net/11427/14656 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/14656
dc.identifier.urihttp://dx.doi.org/10.1186/1742-4690-6-S3-P417
dc.identifier.vancouvercitationStutz H, Powles R, Shephard E, Williamson A. P19-53 LB. Priming with recombinant BCG expressing HIV-1 Gag or RT and boosting with recombinant MVA induces an effective immune response in mice. Retrovirology. 2009; http://hdl.handle.net/11427/14656.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Medical Microbiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2009 Stutz et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/2.0en_ZA
dc.sourceRetrovirologyen_ZA
dc.source.urihttp://www.retrovirology.com/en_ZA
dc.subject.otherWild Type BCGen_ZA
dc.subject.otherBooster Vaccineen_ZA
dc.subject.otherAntigen Specific CD8en_ZA
dc.subject.otherPrimary Vaccineen_ZA
dc.subject.otherrBCG Vaccineen_ZA
dc.subject.otherELISPOT Assayen_ZA
dc.titleP19-53 LB. Priming with recombinant BCG expressing HIV-1 Gag or RT and boosting with recombinant MVA induces an effective immune response in miceen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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