The chemical constituents of Knowltonia capensis.

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dc.contributor.advisorCragg, Gen_ZA
dc.contributor.authorPowrie, Antoinette Heleneen_ZA
dc.date.accessioned2015-01-27T10:04:57Z
dc.date.available2015-01-27T10:04:57Z
dc.date.issued1975en_ZA
dc.descriptionIncludes bibliographical references.en_ZA
dc.description.abstractMany members of the Ranunculaceae have antibacterial and antifungal activity due to the liberation of protoanemonin from ranunculin or from some other, as yet unidentified, precursore Also many members of the family contain alkaloids and, in particular the genus thalictrum of the subfamily Anemoneae has given rise to much interest due to the wide variety of biabenzylisoquinoline and other related alkaloids which have been isolated from it, especially since a number of these have shown antitumour activity. In connection with this it was noted that the genus knowltonia which is also a member of this subfamily had not been subjected to chemical study. Thus a typical member of this genus, Knowltonia capensis, was examined for its chemical constituents. The plant was tested and was found to have antibiotic activity and possibly also antitumour activity, but this has still to be confirmed. Extraction of the dried plant yielded anemonin, choliine and glucose, and revealed that the plant was completely lacking in alkaloids. Extraction of the fresh plant yielded ranunculin and protoanemonin. Thus it was shown that the genus knowltonia,, as typified by Knowltonia capensis, is chemotaxonomically related to the other genera of its subfamily, the Anemoneae, with the exception of the genus thalictrum which appears to be anomalous.en_ZA
dc.identifier.apacitationPowrie, A. H. (1975). <i>The chemical constituents of Knowltonia capensis</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Chemistry. Retrieved from http://hdl.handle.net/11427/12326en_ZA
dc.identifier.chicagocitationPowrie, Antoinette Helene. <i>"The chemical constituents of Knowltonia capensis."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Chemistry, 1975. http://hdl.handle.net/11427/12326en_ZA
dc.identifier.citationPowrie, A. 1975. The chemical constituents of Knowltonia capensis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Powrie, Antoinette Helene AB - Many members of the Ranunculaceae have antibacterial and antifungal activity due to the liberation of protoanemonin from ranunculin or from some other, as yet unidentified, precursore Also many members of the family contain alkaloids and, in particular the genus thalictrum of the subfamily Anemoneae has given rise to much interest due to the wide variety of biabenzylisoquinoline and other related alkaloids which have been isolated from it, especially since a number of these have shown antitumour activity. In connection with this it was noted that the genus knowltonia which is also a member of this subfamily had not been subjected to chemical study. Thus a typical member of this genus, Knowltonia capensis, was examined for its chemical constituents. The plant was tested and was found to have antibiotic activity and possibly also antitumour activity, but this has still to be confirmed. Extraction of the dried plant yielded anemonin, choliine and glucose, and revealed that the plant was completely lacking in alkaloids. Extraction of the fresh plant yielded ranunculin and protoanemonin. Thus it was shown that the genus knowltonia,, as typified by Knowltonia capensis, is chemotaxonomically related to the other genera of its subfamily, the Anemoneae, with the exception of the genus thalictrum which appears to be anomalous. DA - 1975 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1975 T1 - The chemical constituents of Knowltonia capensis TI - The chemical constituents of Knowltonia capensis UR - http://hdl.handle.net/11427/12326 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12326
dc.identifier.vancouvercitationPowrie AH. The chemical constituents of Knowltonia capensis. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Chemistry, 1975 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12326en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Chemistryen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherChemistryen_ZA
dc.titleThe chemical constituents of Knowltonia capensis.en_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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