Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1

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dc.contributor.advisorIlling, Nicolaen_ZA
dc.contributor.authorBredenkamp, Nicholasen_ZA
dc.date.accessioned2014-07-30T17:35:36Z
dc.date.available2014-07-30T17:35:36Z
dc.date.issued2006en_ZA
dc.descriptionIncludes bibliographical references (leaves 103-110).
dc.description.abstractForhead box G1 (FoxG1) is a winged-helix transcription factor that plays a crucial role in the development of the telecephalon, the most rostral region of the brain Here, FoxG1 acts as a transcriptional repressor and maintains the population of cortical progenitor cells by promoting their proliferation and inhibiting differrentiation. Vertebrate FoxG1 orthologs have highly conserved DNA-binding and corbosy-terminal domains that have functional roles. Conversely, no functional role has yet been assigned to the N-terminal domain which shows a high degree of variability across vertebrates, with a remarkable stretch of consecutive histidine, proline and glutamine (HPQ) residues in the mammalian orthologs. In this study it was tested whether differences in FoxG1 sequence amongst vertebrates might account for the increased cortex size of mammals compared to non-mammals. Furthermore, changes in the sub-cellular localization of FoxG1 in response to fibroblast growth factor 2 (FGF-2) were investigated in a neural precursor cell line.en_ZA
dc.identifier.apacitationBredenkamp, N. (2006). <i>Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/4243en_ZA
dc.identifier.chicagocitationBredenkamp, Nicholas. <i>"Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2006. http://hdl.handle.net/11427/4243en_ZA
dc.identifier.citationBredenkamp, N. 2006. Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Bredenkamp, Nicholas AB - Forhead box G1 (FoxG1) is a winged-helix transcription factor that plays a crucial role in the development of the telecephalon, the most rostral region of the brain Here, FoxG1 acts as a transcriptional repressor and maintains the population of cortical progenitor cells by promoting their proliferation and inhibiting differrentiation. Vertebrate FoxG1 orthologs have highly conserved DNA-binding and corbosy-terminal domains that have functional roles. Conversely, no functional role has yet been assigned to the N-terminal domain which shows a high degree of variability across vertebrates, with a remarkable stretch of consecutive histidine, proline and glutamine (HPQ) residues in the mammalian orthologs. In this study it was tested whether differences in FoxG1 sequence amongst vertebrates might account for the increased cortex size of mammals compared to non-mammals. Furthermore, changes in the sub-cellular localization of FoxG1 in response to fibroblast growth factor 2 (FGF-2) were investigated in a neural precursor cell line. DA - 2006 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2006 T1 - Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1 TI - Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1 UR - http://hdl.handle.net/11427/4243 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/4243
dc.identifier.vancouvercitationBredenkamp N. Evolutionary analysis and functional characterization of the forkhead transcription factor FoxG1. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2006 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/4243en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMolecular Biologyen_ZA
dc.titleEvolutionary analysis and functional characterization of the forkhead transcription factor FoxG1en_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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