An in depth study of human papillomavirus diversity in South African women infected with HIV

Simple item page
dc.contributor.advisorHitzeroth, Ingaen_ZA
dc.contributor.advisorWilliamson, Anna-Liseen_ZA
dc.contributor.advisorRybicki, Eden_ZA
dc.contributor.authorSalimo, Anna Ten_ZA
dc.date.accessioned2015-02-04T19:14:58Z
dc.date.available2015-02-04T19:14:58Z
dc.date.issued2009en_ZA
dc.descriptionIncludes abstract. Includes bibliographical references (leaves 109-129).en_ZA
dc.description.abstractCervical cancer is the second most common cancer affecting women and in most developing countries it remains the leading cause of cancer deaths. In South Africa, more than 3 400 women succumb to the disease every year and 1 in 31 women develop cervical cancer. The causative agent for cervical cancer is the Human papillomavirus (HPV). High-risk (carcinogenic) HPV types have been linked with 99% of the incidences of cervical cancer. The most common types identified in almost 70% of cervical cancer cases worldwide are HPV 16 and 18. HPV infection is very common in young healthy women and most immunocompetent individuals can clear HPV infection. However, in immunosuppresed women, clearance by host immune system is impaired. In addition, multiple HPV infections are quite common in women with Human immunodeficiency virus (HIV) infections. The objectives of this study were to identify HPV types in South African women who also had HIV infection, and secondarily, to determine if recombination of HPV genomes occurs. Determining the HPV types circulating in this country is important to enable identification of most common HPV types, in order to guide the development of vaccines against HPV infection. HPV genotyping was performed by the commercial Roche Linear Array HPV Genotyping Test.en_ZA
dc.identifier.apacitationSalimo, A. T. (2009). <i>An in depth study of human papillomavirus diversity in South African women infected with HIV</i>. (Thesis). University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology. Retrieved from http://hdl.handle.net/11427/12378en_ZA
dc.identifier.chicagocitationSalimo, Anna T. <i>"An in depth study of human papillomavirus diversity in South African women infected with HIV."</i> Thesis., University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2009. http://hdl.handle.net/11427/12378en_ZA
dc.identifier.citationSalimo, A. 2009. An in depth study of human papillomavirus diversity in South African women infected with HIV. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Salimo, Anna T AB - Cervical cancer is the second most common cancer affecting women and in most developing countries it remains the leading cause of cancer deaths. In South Africa, more than 3 400 women succumb to the disease every year and 1 in 31 women develop cervical cancer. The causative agent for cervical cancer is the Human papillomavirus (HPV). High-risk (carcinogenic) HPV types have been linked with 99% of the incidences of cervical cancer. The most common types identified in almost 70% of cervical cancer cases worldwide are HPV 16 and 18. HPV infection is very common in young healthy women and most immunocompetent individuals can clear HPV infection. However, in immunosuppresed women, clearance by host immune system is impaired. In addition, multiple HPV infections are quite common in women with Human immunodeficiency virus (HIV) infections. The objectives of this study were to identify HPV types in South African women who also had HIV infection, and secondarily, to determine if recombination of HPV genomes occurs. Determining the HPV types circulating in this country is important to enable identification of most common HPV types, in order to guide the development of vaccines against HPV infection. HPV genotyping was performed by the commercial Roche Linear Array HPV Genotyping Test. DA - 2009 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2009 T1 - An in depth study of human papillomavirus diversity in South African women infected with HIV TI - An in depth study of human papillomavirus diversity in South African women infected with HIV UR - http://hdl.handle.net/11427/12378 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/12378
dc.identifier.vancouvercitationSalimo AT. An in depth study of human papillomavirus diversity in South African women infected with HIV. [Thesis]. University of Cape Town ,Faculty of Science ,Department of Molecular and Cell Biology, 2009 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/12378en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Molecular and Cell Biologyen_ZA
dc.publisher.facultyFaculty of Scienceen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherMolecular and Cell Biologyen_ZA
dc.titleAn in depth study of human papillomavirus diversity in South African women infected with HIVen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
thesis_sci_2009_salimo_a_t (1).pdf
Size:
8.06 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Masters