Abnormal myocardial perfusion correlates with impaired systolic strain and diastolic strain rate in systemic lupus erythematosus: a cardiovascular magnetic resonance study

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dc.contributor.authorNtusi, Ntobekoen_ZA
dc.contributor.authorSever, Emilyen_ZA
dc.contributor.authorLockey, Josephen_ZA
dc.contributor.authorFrancis, Janeen_ZA
dc.contributor.authorPiechnik, Stefanen_ZA
dc.contributor.authorFerreira, Vanessaen_ZA
dc.contributor.authorMatthews, Paulen_ZA
dc.contributor.authorWordsworth, Paulen_ZA
dc.contributor.authorNeubauer, Stefanen_ZA
dc.contributor.authorKaramitsos, Theodorosen_ZA
dc.date.accessioned2015-12-07T08:47:09Z
dc.date.available2015-12-07T08:47:09Z
dc.date.issued2015en_ZA
dc.description.abstractSystemic lupus erythematosus (SLE) is a systemic autoimmune disorder that commonly affects the heart, resulting in a 7 to 9 times greater incidence of cardiovascular disease (CVD) in SLE patients compared to healthy controls. Female patients with SLE between 35 and 44 years old have an incidence of myocardial infarction over 50 times greater than that observed in the Framingham cohort. The clinical utility of cardiovascular magnetic resonance (CMR) first-pass perfusion for assessment of myocardial ischaemia is well-established. We hypothesised that CMR including stress first-pass perfusion would be able to detect coronary microvascular disease and subtle functional abnormalities in SLE and aimed to detect myocardial ischaemia in SLE using adenosine stress perfusion CMR.en_ZA
dc.identifier.apacitationNtusi, N., Sever, E., Lockey, J., Francis, J., Piechnik, S., Ferreira, V., ... Karamitsos, T. (2015). Abnormal myocardial perfusion correlates with impaired systolic strain and diastolic strain rate in systemic lupus erythematosus: a cardiovascular magnetic resonance study. <i>Journal of Cardiovascular Magnetic Resonance</i>, http://hdl.handle.net/11427/15629en_ZA
dc.identifier.chicagocitationNtusi, Ntobeko, Emily Sever, Joseph Lockey, Jane Francis, Stefan Piechnik, Vanessa Ferreira, Paul Matthews, Paul Wordsworth, Stefan Neubauer, and Theodoros Karamitsos "Abnormal myocardial perfusion correlates with impaired systolic strain and diastolic strain rate in systemic lupus erythematosus: a cardiovascular magnetic resonance study." <i>Journal of Cardiovascular Magnetic Resonance</i> (2015) http://hdl.handle.net/11427/15629en_ZA
dc.identifier.citationNtusi, N. A., Sever, E., Lockey, J., Francis, J. M., Piechnik, S. K., Ferreira, V. M., ... & Karamitsos, T. D. (2015). Abnormal myocardial perfusion correlates with impaired systolic strain and diastolic strain rate in systemic lupus erythematosus: a cardiovascular magnetic resonance study. Journal of Cardiovascular Magnetic Resonance, 17(Suppl 1), O81.en_ZA
dc.identifier.ris TY - Journal Article AU - Ntusi, Ntobeko AU - Sever, Emily AU - Lockey, Joseph AU - Francis, Jane AU - Piechnik, Stefan AU - Ferreira, Vanessa AU - Matthews, Paul AU - Wordsworth, Paul AU - Neubauer, Stefan AU - Karamitsos, Theodoros AB - Systemic lupus erythematosus (SLE) is a systemic autoimmune disorder that commonly affects the heart, resulting in a 7 to 9 times greater incidence of cardiovascular disease (CVD) in SLE patients compared to healthy controls. Female patients with SLE between 35 and 44 years old have an incidence of myocardial infarction over 50 times greater than that observed in the Framingham cohort. The clinical utility of cardiovascular magnetic resonance (CMR) first-pass perfusion for assessment of myocardial ischaemia is well-established. We hypothesised that CMR including stress first-pass perfusion would be able to detect coronary microvascular disease and subtle functional abnormalities in SLE and aimed to detect myocardial ischaemia in SLE using adenosine stress perfusion CMR. DA - 2015 DB - OpenUCT DO - 10.1186/1532-429X-17-S1-O81 DP - University of Cape Town J1 - Journal of Cardiovascular Magnetic Resonance LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Abnormal myocardial perfusion correlates with impaired systolic strain and diastolic strain rate in systemic lupus erythematosus: a cardiovascular magnetic resonance study TI - Abnormal myocardial perfusion correlates with impaired systolic strain and diastolic strain rate in systemic lupus erythematosus: a cardiovascular magnetic resonance study UR - http://hdl.handle.net/11427/15629 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15629
dc.identifier.urihttp://dx.doi.org/10.1186/1532-429X-17-S1-O81
dc.identifier.vancouvercitationNtusi N, Sever E, Lockey J, Francis J, Piechnik S, Ferreira V, et al. Abnormal myocardial perfusion correlates with impaired systolic strain and diastolic strain rate in systemic lupus erythematosus: a cardiovascular magnetic resonance study. Journal of Cardiovascular Magnetic Resonance. 2015; http://hdl.handle.net/11427/15629.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDivision of Cardiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2015 Ntusi et al; licensee BioMed Central Ltd.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourceJournal of Cardiovascular Magnetic Resonanceen_ZA
dc.source.urihttp://www.jcmr-online.com/en_ZA
dc.subject.otherSystemic lupus erythematosus (SLE)en_ZA
dc.subject.othersystemic autoimmune disorderen_ZA
dc.subject.othercardiovascular disease (CVD)en_ZA
dc.titleAbnormal myocardial perfusion correlates with impaired systolic strain and diastolic strain rate in systemic lupus erythematosus: a cardiovascular magnetic resonance studyen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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