Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean

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dc.contributor.authorOlsen, Elisabeth K
dc.contributor.authorde Cerf, Christopher K
dc.contributor.authorDziwornu, Godwin A
dc.contributor.authorPuccinelli, Eleonora
dc.contributor.authorAnsorge, Iabelle J
dc.contributor.authorSamaai, Toufiek
dc.contributor.authorDingle, Laura M K
dc.contributor.authorEdkins, Adrienne L
dc.contributor.authorSunassee, Suthananda N
dc.date.accessioned2021-10-08T07:16:11Z
dc.date.available2021-10-08T07:16:11Z
dc.date.issued2016
dc.description.abstractAbstractOver the past 50 years, marine invertebrates, especially sponges, have proven to be a valuable source of new and/or bioactive natural products that have the potential to be further developed as lead compounds for pharmaceutical applications. Although marine benthic invertebrate communities occurring off the coast of South Africa have been explored for their biomedicinal potential, the natural product investigation of marine sponges from the sub-Antarctic Islands in the Southern Ocean for the presence of bioactive secondary metabolites has been relatively unexplored thus far. We report here the results for the biological screening of both aqueous and organic extracts prepared from nine specimens of eight species of marine sponges, collected from around Marion Island and the Prince Edward Islands in the Southern Ocean, for their cytotoxic activity against three cancer cell lines. The results obtained through this multidisciplinary collaborative research effort by exclusively South African institutions has provided an exciting opportunity to discover cytotoxic compounds from sub-Antarctic sponges, whilst contributing to our understanding of the biodiversity and geographic distributions of these cold-water invertebrates. Therefore, we acknowledge here the various contributions of the diverse scientific disciplines that played a pivotal role in providing the necessary platform for the future natural products chemistry investigation of these marine sponges from the sub- Antarctic Islands and the Southern Ocean.
dc.identifier.apacitationOlsen, E. K., de Cerf, C. K., Dziwornu, G. A., Puccinelli, E., Ansorge, I. J., Samaai, T., ... Sunassee, S. N. (2016). Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean. <i>South African Journal of Science</i>, Volume 112(Number 11/12), 174 - 177. http://hdl.handle.net/11427/34790en_ZA
dc.identifier.chicagocitationOlsen, Elisabeth K, Christopher K de Cerf, Godwin A Dziwornu, Eleonora Puccinelli, Iabelle J Ansorge, Toufiek Samaai, Laura M K Dingle, Adrienne L Edkins, and Suthananda N Sunassee "Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean." <i>South African Journal of Science</i> Volume 112, Number 11/12. (2016): 174 - 177. http://hdl.handle.net/11427/34790en_ZA
dc.identifier.citationOlsen, E.K., de Cerf, C.K., Dziwornu, G.A., Puccinelli, E., Ansorge, I.J., Samaai, T., Dingle, L.M.K. & Edkins, A.L. et al. 2016. Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean. <i>South African Journal of Science.</i> Volume 112(Number 11/12):174 - 177. http://hdl.handle.net/11427/34790en_ZA
dc.identifier.issn0038-2353
dc.identifier.issn1996-7489
dc.identifier.ris TY - Journal Article AU - Olsen, Elisabeth K AU - de Cerf, Christopher K AU - Dziwornu, Godwin A AU - Puccinelli, Eleonora AU - Ansorge, Iabelle J AU - Samaai, Toufiek AU - Dingle, Laura M K AU - Edkins, Adrienne L AU - Sunassee, Suthananda N AB - AbstractOver the past 50 years, marine invertebrates, especially sponges, have proven to be a valuable source of new and/or bioactive natural products that have the potential to be further developed as lead compounds for pharmaceutical applications. Although marine benthic invertebrate communities occurring off the coast of South Africa have been explored for their biomedicinal potential, the natural product investigation of marine sponges from the sub-Antarctic Islands in the Southern Ocean for the presence of bioactive secondary metabolites has been relatively unexplored thus far. We report here the results for the biological screening of both aqueous and organic extracts prepared from nine specimens of eight species of marine sponges, collected from around Marion Island and the Prince Edward Islands in the Southern Ocean, for their cytotoxic activity against three cancer cell lines. The results obtained through this multidisciplinary collaborative research effort by exclusively South African institutions has provided an exciting opportunity to discover cytotoxic compounds from sub-Antarctic sponges, whilst contributing to our understanding of the biodiversity and geographic distributions of these cold-water invertebrates. Therefore, we acknowledge here the various contributions of the diverse scientific disciplines that played a pivotal role in providing the necessary platform for the future natural products chemistry investigation of these marine sponges from the sub- Antarctic Islands and the Southern Ocean. DA - 2016 DB - OpenUCT DP - University of Cape Town IS - Number 11/12 J1 - South African Journal of Science LK - https://open.uct.ac.za PY - 2016 SM - 0038-2353 SM - 1996-7489 T1 - Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean TI - Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean UR - http://hdl.handle.net/11427/34790 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34790
dc.identifier.vancouvercitationOlsen EK, de Cerf CK, Dziwornu GA, Puccinelli E, Ansorge IJ, Samaai T, et al. Cytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean. South African Journal of Science. 2016;Volume 112(Number 11/12):174 - 177. http://hdl.handle.net/11427/34790.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Chemistry
dc.publisher.facultyFaculty of Science
dc.sourceSouth African Journal of Science
dc.source.journalissueNumber 11/12
dc.source.journalvolumeVolume 112
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.17159/sajs.2016/20160202
dc.subject.othermultidisciplinary
dc.subject.otherPrince Edward Islands
dc.subject.othermarine natural products
dc.subject.othercancer cell lines
dc.subject.otherdrug discovery
dc.titleCytotoxic activity of marine sponge extracts from the sub-Antarctic Islands and the Southern Ocean
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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