Addison's disease symptoms - a cross sectional study in urban South Africa

Simple item page
dc.contributor.authorRoss, Ian Louisen_ZA
dc.contributor.authorLevitt, Naomi Sen_ZA
dc.date.accessioned2015-11-23T12:29:19Z
dc.date.available2015-11-23T12:29:19Z
dc.date.issued2013en_ZA
dc.description.abstractBACKGROUND: Addison's disease is a potentially life-threatening disorder, and prompt diagnosis, and introduction of steroid replacement has resulted in near normal life-expectancy. There are limited data describing the clinical presentation of Addison's disease in South Africa. It is hypothesised that patients may present in advanced state of ill-health, compared to Western countries. Patients A national database of patients was compiled from primary care, referral centres and private practices. 148 patients were enrolled (97 white, 34 mixed ancestry, 5 Asian and 12 black). METHODS: Demographic and clinical data were elicited using questionnaires. Biochemical data were obtained from folder reviews and laboratory archived results. RESULTS: The majority of the cohort was women (62%). The median and inter-quartile age range (IQR) of patients at enrolment was 46.0 (32.0-61.0) years, with a wide range from 2.8-88.0 years. The median and IQR age at initial diagnosis was 34.0 (20.0-45.0) years (range 0.02-77.0) years, indicating that at the time of enrolment, the patients, on average, were diagnosed with Addison's disease 12 years previously. Hyperpigmentation was observed in 76%, nausea and vomiting occurred in more than 40%, and weight loss was noted in 25%. Loss of consciousness as a presenting feature was recorded in 20 %. with a 95% confidence interval [CI] of (14-28%) and shock occurred in 5% CI (1.5-8.5%). Case-finding was recorded at 3.1 per million. CONCLUSIONS: The usual constellation of hyperpigmentation, nausea, vomiting and weight loss suggests Addison's disease, but a significant proportion present with an advanced state of ill-health and Addisonian crises. A lower prevalence rate, compared to Western countries is suggested.en_ZA
dc.identifier.apacitationRoss, I. L., & Levitt, N. S. (2013). Addison's disease symptoms - a cross sectional study in urban South Africa. <i>PLoS One</i>, http://hdl.handle.net/11427/15297en_ZA
dc.identifier.chicagocitationRoss, Ian Louis, and Naomi S Levitt "Addison's disease symptoms - a cross sectional study in urban South Africa." <i>PLoS One</i> (2013) http://hdl.handle.net/11427/15297en_ZA
dc.identifier.citationRoss, I. L., & Levitt, N. S. (2013). Addison's disease symptoms - a cross sectional study in urban South Africa. PloS one, 8(1), e53526. doi:10.1371/journal.pone.0053526en_ZA
dc.identifier.ris TY - Journal Article AU - Ross, Ian Louis AU - Levitt, Naomi S AB - BACKGROUND: Addison's disease is a potentially life-threatening disorder, and prompt diagnosis, and introduction of steroid replacement has resulted in near normal life-expectancy. There are limited data describing the clinical presentation of Addison's disease in South Africa. It is hypothesised that patients may present in advanced state of ill-health, compared to Western countries. Patients A national database of patients was compiled from primary care, referral centres and private practices. 148 patients were enrolled (97 white, 34 mixed ancestry, 5 Asian and 12 black). METHODS: Demographic and clinical data were elicited using questionnaires. Biochemical data were obtained from folder reviews and laboratory archived results. RESULTS: The majority of the cohort was women (62%). The median and inter-quartile age range (IQR) of patients at enrolment was 46.0 (32.0-61.0) years, with a wide range from 2.8-88.0 years. The median and IQR age at initial diagnosis was 34.0 (20.0-45.0) years (range 0.02-77.0) years, indicating that at the time of enrolment, the patients, on average, were diagnosed with Addison's disease 12 years previously. Hyperpigmentation was observed in 76%, nausea and vomiting occurred in more than 40%, and weight loss was noted in 25%. Loss of consciousness as a presenting feature was recorded in 20 %. with a 95% confidence interval [CI] of (14-28%) and shock occurred in 5% CI (1.5-8.5%). Case-finding was recorded at 3.1 per million. CONCLUSIONS: The usual constellation of hyperpigmentation, nausea, vomiting and weight loss suggests Addison's disease, but a significant proportion present with an advanced state of ill-health and Addisonian crises. A lower prevalence rate, compared to Western countries is suggested. DA - 2013 DB - OpenUCT DO - 10.1371/journal.pone.0053526 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Addison's disease symptoms - a cross sectional study in urban South Africa TI - Addison's disease symptoms - a cross sectional study in urban South Africa UR - http://hdl.handle.net/11427/15297 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15297
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0053526
dc.identifier.vancouvercitationRoss IL, Levitt NS. Addison's disease symptoms - a cross sectional study in urban South Africa. PLoS One. 2013; http://hdl.handle.net/11427/15297.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDivision of Endocrinology and Diabetologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2013 Ross, Levitten_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherHydrocortisoneen_ZA
dc.subject.otherSouth Africaen_ZA
dc.subject.otherTraditional ACTH stimulation testen_ZA
dc.subject.otherVomitingen_ZA
dc.subject.otherNauseaen_ZA
dc.subject.otherWeight lossen_ZA
dc.subject.otherDemographyen_ZA
dc.subject.otherSyncopeen_ZA
dc.titleAddison's disease symptoms - a cross sectional study in urban South Africaen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ross_Addisons_Disease_Symptoms_2013.pdf
Size:
233.45 KB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles