Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis
dc.contributor.author | Heinsbroek, Sigrid E M | en_ZA |
dc.contributor.author | Taylor, Philip R | en_ZA |
dc.contributor.author | Martinez, Fernando O | en_ZA |
dc.contributor.author | Martinez-Pomares, Luisa | en_ZA |
dc.contributor.author | Brown, Gordon D | en_ZA |
dc.contributor.author | Gordon, Siamon | en_ZA |
dc.date.accessioned | 2015-11-18T07:07:03Z | |
dc.date.available | 2015-11-18T07:07:03Z | |
dc.date.issued | 2008 | en_ZA |
dc.description.abstract | Author Summary Infection by Candida albicans has increased as a result of immunosuppression associated with AIDS and organ transplantation. We assessed the role of three pattern recognition receptors, namely Dectin-1 (a beta glucan receptor), the type 3 complement receptor (CR3), and the mannose receptor, in mediating uptake of this fungus. These receptors are known to recognize structures on the C. albicans cell wall, but their exact contribution to binding and uptake is still unclear. We show that only Dectin-1 plays a major role in binding and uptake of C. albicans . Furthermore, we are the first to find that these receptors sample the internalized particle in a sequential manner; intracellular mannose receptor is recruited later and is involved in secretion of immune modulators. These findings provide a better understanding of the innate immune mechanisms involved in protection against this medically important fungal pathogen. | en_ZA |
dc.identifier.apacitation | Heinsbroek, S. E. M., Taylor, P. R., Martinez, F. O., Martinez-Pomares, L., Brown, G. D., & Gordon, S. (2008). Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis. <i>PLoS One</i>, http://hdl.handle.net/11427/15125 | en_ZA |
dc.identifier.chicagocitation | Heinsbroek, Sigrid E M, Philip R Taylor, Fernando O Martinez, Luisa Martinez-Pomares, Gordon D Brown, and Siamon Gordon "Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis." <i>PLoS One</i> (2008) http://hdl.handle.net/11427/15125 | en_ZA |
dc.identifier.citation | Heinsbroek, S. E., Taylor, P. R., Martinez, F. O., Martinez-Pomares, L., Brown, G. D., & Gordon, S. (2008). Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis. PLoS Pathog, 4(11), e1000218. doi:10.1371/journal.ppat.1000218 | en_ZA |
dc.identifier.ris | TY - Journal Article AU - Heinsbroek, Sigrid E M AU - Taylor, Philip R AU - Martinez, Fernando O AU - Martinez-Pomares, Luisa AU - Brown, Gordon D AU - Gordon, Siamon AB - Author Summary Infection by Candida albicans has increased as a result of immunosuppression associated with AIDS and organ transplantation. We assessed the role of three pattern recognition receptors, namely Dectin-1 (a beta glucan receptor), the type 3 complement receptor (CR3), and the mannose receptor, in mediating uptake of this fungus. These receptors are known to recognize structures on the C. albicans cell wall, but their exact contribution to binding and uptake is still unclear. We show that only Dectin-1 plays a major role in binding and uptake of C. albicans . Furthermore, we are the first to find that these receptors sample the internalized particle in a sequential manner; intracellular mannose receptor is recruited later and is involved in secretion of immune modulators. These findings provide a better understanding of the innate immune mechanisms involved in protection against this medically important fungal pathogen. DA - 2008 DB - OpenUCT DO - 10.1371/journal.ppat.1000218 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis TI - Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis UR - http://hdl.handle.net/11427/15125 ER - | en_ZA |
dc.identifier.uri | http://hdl.handle.net/11427/15125 | |
dc.identifier.uri | http://dx.doi.org/10.1371/journal.ppat.1000218 | |
dc.identifier.vancouvercitation | Heinsbroek SEM, Taylor PR, Martinez FO, Martinez-Pomares L, Brown GD, Gordon S. Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis. PLoS One. 2008; http://hdl.handle.net/11427/15125. | en_ZA |
dc.language.iso | eng | en_ZA |
dc.publisher | Public Library of Science | en_ZA |
dc.publisher.department | Institute of Infectious Disease and Molecular Medicine | en_ZA |
dc.publisher.faculty | Faculty of Health Sciences | en_ZA |
dc.publisher.institution | University of Cape Town | |
dc.rights | This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en_ZA |
dc.rights.holder | © 2008 Heinsbroek et al | en_ZA |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0 | en_ZA |
dc.source | PLoS One | en_ZA |
dc.source.uri | http://journals.plos.org/plospathogens | en_ZA |
dc.subject.other | Candida albicans | en_ZA |
dc.subject.other | Phagocytosis | en_ZA |
dc.subject.other | Phagosomes | en_ZA |
dc.subject.other | Cell membranes | en_ZA |
dc.subject.other | Pattern recognition receptors | en_ZA |
dc.subject.other | Macrophages | en_ZA |
dc.subject.other | Membrane staining | en_ZA |
dc.subject.other | Cytokines | en_ZA |
dc.title | Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis | en_ZA |
dc.type | Journal Article | en_ZA |
uct.type.filetype | Text | |
uct.type.filetype | Image | |
uct.type.publication | Research | en_ZA |
uct.type.resource | Article | en_ZA |
Files
Original bundle
1 - 1 of 1
Loading...
- Name:
- Heinsbroek_Stage_specific_sampling_2008.pdf
- Size:
- 805.73 KB
- Format:
- Adobe Portable Document Format
- Description: