Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis

dc.contributor.authorHeinsbroek, Sigrid E Men_ZA
dc.contributor.authorTaylor, Philip Ren_ZA
dc.contributor.authorMartinez, Fernando Oen_ZA
dc.contributor.authorMartinez-Pomares, Luisaen_ZA
dc.contributor.authorBrown, Gordon Den_ZA
dc.contributor.authorGordon, Siamonen_ZA
dc.date.accessioned2015-11-18T07:07:03Z
dc.date.available2015-11-18T07:07:03Z
dc.date.issued2008en_ZA
dc.description.abstractAuthor Summary Infection by Candida albicans has increased as a result of immunosuppression associated with AIDS and organ transplantation. We assessed the role of three pattern recognition receptors, namely Dectin-1 (a beta glucan receptor), the type 3 complement receptor (CR3), and the mannose receptor, in mediating uptake of this fungus. These receptors are known to recognize structures on the C. albicans cell wall, but their exact contribution to binding and uptake is still unclear. We show that only Dectin-1 plays a major role in binding and uptake of C. albicans . Furthermore, we are the first to find that these receptors sample the internalized particle in a sequential manner; intracellular mannose receptor is recruited later and is involved in secretion of immune modulators. These findings provide a better understanding of the innate immune mechanisms involved in protection against this medically important fungal pathogen.en_ZA
dc.identifier.apacitationHeinsbroek, S. E. M., Taylor, P. R., Martinez, F. O., Martinez-Pomares, L., Brown, G. D., & Gordon, S. (2008). Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis. <i>PLoS One</i>, http://hdl.handle.net/11427/15125en_ZA
dc.identifier.chicagocitationHeinsbroek, Sigrid E M, Philip R Taylor, Fernando O Martinez, Luisa Martinez-Pomares, Gordon D Brown, and Siamon Gordon "Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis." <i>PLoS One</i> (2008) http://hdl.handle.net/11427/15125en_ZA
dc.identifier.citationHeinsbroek, S. E., Taylor, P. R., Martinez, F. O., Martinez-Pomares, L., Brown, G. D., & Gordon, S. (2008). Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis. PLoS Pathog, 4(11), e1000218. doi:10.1371/journal.ppat.1000218en_ZA
dc.identifier.ris TY - Journal Article AU - Heinsbroek, Sigrid E M AU - Taylor, Philip R AU - Martinez, Fernando O AU - Martinez-Pomares, Luisa AU - Brown, Gordon D AU - Gordon, Siamon AB - Author Summary Infection by Candida albicans has increased as a result of immunosuppression associated with AIDS and organ transplantation. We assessed the role of three pattern recognition receptors, namely Dectin-1 (a beta glucan receptor), the type 3 complement receptor (CR3), and the mannose receptor, in mediating uptake of this fungus. These receptors are known to recognize structures on the C. albicans cell wall, but their exact contribution to binding and uptake is still unclear. We show that only Dectin-1 plays a major role in binding and uptake of C. albicans . Furthermore, we are the first to find that these receptors sample the internalized particle in a sequential manner; intracellular mannose receptor is recruited later and is involved in secretion of immune modulators. These findings provide a better understanding of the innate immune mechanisms involved in protection against this medically important fungal pathogen. DA - 2008 DB - OpenUCT DO - 10.1371/journal.ppat.1000218 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2008 T1 - Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis TI - Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis UR - http://hdl.handle.net/11427/15125 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15125
dc.identifier.urihttp://dx.doi.org/10.1371/journal.ppat.1000218
dc.identifier.vancouvercitationHeinsbroek SEM, Taylor PR, Martinez FO, Martinez-Pomares L, Brown GD, Gordon S. Stage-specific sampling by pattern recognition receptors during Candida albicans phagocytosis. PLoS One. 2008; http://hdl.handle.net/11427/15125.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentInstitute of Infectious Disease and Molecular Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2008 Heinsbroek et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plospathogensen_ZA
dc.subject.otherCandida albicansen_ZA
dc.subject.otherPhagocytosisen_ZA
dc.subject.otherPhagosomesen_ZA
dc.subject.otherCell membranesen_ZA
dc.subject.otherPattern recognition receptorsen_ZA
dc.subject.otherMacrophagesen_ZA
dc.subject.otherMembrane stainingen_ZA
dc.subject.otherCytokinesen_ZA
dc.titleStage-specific sampling by pattern recognition receptors during Candida albicans phagocytosisen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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