In vivo molecular dissection of the effects of HIV-1 in active tuberculosis

Simple item page
dc.contributor.authorBell, Lucy C Ken_ZA
dc.contributor.authorPollara, Gabrieleen_ZA
dc.contributor.authorPascoe, Mellissaen_ZA
dc.contributor.authorTomlinson, Gillian Sen_ZA
dc.contributor.authorLehloenya, Rannakoe Jen_ZA
dc.contributor.authorRoe, Jenniferen_ZA
dc.contributor.authorMeldau, Richarden_ZA
dc.contributor.authorMiller, Robert Fen_ZA
dc.contributor.authorRamsay, Alanen_ZA
dc.contributor.authorChain, Benjamin Men_ZA
dc.contributor.authorDheda, Keertanen_ZA
dc.contributor.authorNoursadeghi, Mahdaden_ZA
dc.date.accessioned2016-04-13T12:35:47Z
dc.date.available2016-04-13T12:35:47Z
dc.date.issued2016en_ZA
dc.description.abstractAuthor Summary HIV-1 infected people have substantially increased risk of tuberculosis (TB) leading to a large burden of disease worldwide. We aimed to investigate how HIV-1 causes this effect by altering human immune responses. We measured the products of all immune genes at injection sites of sterilized TB under the skin, in order to look for differences between TB patients with and without HIV-1. We found that the predominant effect of early HIV-1 infection was to diminish a component of immune responses that contributes to prevention of harmful inflammation. In more advanced HIV-1, we found almost complete absence of any immune response to TB except for immune activity which is normally part of our defence against viruses, but may also weaken immune protection against TB. In some patients, TB becomes apparent after starting treatment for HIV-1. In these patients we found that most immune responses had recovered to normal levels, but that one type of response sometimes associated with asthma and allergies was exaggerated. Our findings provide new insights into how HIV-1 can affect immune responses and changes to the immune system that are associated with risk of TB, which will inform the development of new strategies to improve protective immunity.en_ZA
dc.identifier.apacitationBell, L. C. K., Pollara, G., Pascoe, M., Tomlinson, G. S., Lehloenya, R. J., Roe, J., ... Noursadeghi, M. (2016). In vivo molecular dissection of the effects of HIV-1 in active tuberculosis. <i>PLoS One</i>, http://hdl.handle.net/11427/18853en_ZA
dc.identifier.chicagocitationBell, Lucy C K, Gabriele Pollara, Mellissa Pascoe, Gillian S Tomlinson, Rannakoe J Lehloenya, Jennifer Roe, Richard Meldau, et al "In vivo molecular dissection of the effects of HIV-1 in active tuberculosis." <i>PLoS One</i> (2016) http://hdl.handle.net/11427/18853en_ZA
dc.identifier.citationBell, L. C., Pollara, G., Pascoe, M., Tomlinson, G. S., Lehloenya, R. J., Roe, J., ... & Dheda, K. (2016). In vivo molecular dissection of the effects of HIV-1 in active tuberculosis. PLoS Pathog, 12(3), e1005469. doi:10.1371/journal.ppat.1005469en_ZA
dc.identifier.ris TY - Journal Article AU - Bell, Lucy C K AU - Pollara, Gabriele AU - Pascoe, Mellissa AU - Tomlinson, Gillian S AU - Lehloenya, Rannakoe J AU - Roe, Jennifer AU - Meldau, Richard AU - Miller, Robert F AU - Ramsay, Alan AU - Chain, Benjamin M AU - Dheda, Keertan AU - Noursadeghi, Mahdad AB - Author Summary HIV-1 infected people have substantially increased risk of tuberculosis (TB) leading to a large burden of disease worldwide. We aimed to investigate how HIV-1 causes this effect by altering human immune responses. We measured the products of all immune genes at injection sites of sterilized TB under the skin, in order to look for differences between TB patients with and without HIV-1. We found that the predominant effect of early HIV-1 infection was to diminish a component of immune responses that contributes to prevention of harmful inflammation. In more advanced HIV-1, we found almost complete absence of any immune response to TB except for immune activity which is normally part of our defence against viruses, but may also weaken immune protection against TB. In some patients, TB becomes apparent after starting treatment for HIV-1. In these patients we found that most immune responses had recovered to normal levels, but that one type of response sometimes associated with asthma and allergies was exaggerated. Our findings provide new insights into how HIV-1 can affect immune responses and changes to the immune system that are associated with risk of TB, which will inform the development of new strategies to improve protective immunity. DA - 2016 DB - OpenUCT DO - 10.1371/journal.ppat.1005469 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - In vivo molecular dissection of the effects of HIV-1 in active tuberculosis TI - In vivo molecular dissection of the effects of HIV-1 in active tuberculosis UR - http://hdl.handle.net/11427/18853 ER - en_ZA
dc.identifier.urihttp://dx.doi.org/10.1371/journal.ppat.1005469en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/18853
dc.identifier.vancouvercitationBell LCK, Pollara G, Pascoe M, Tomlinson GS, Lehloenya RJ, Roe J, et al. In vivo molecular dissection of the effects of HIV-1 in active tuberculosis. PLoS One. 2016; http://hdl.handle.net/11427/18853.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDivision of Pulmonologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2016 Bell et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plospathogensen_ZA
dc.subject.otherTuberculosisen_ZA
dc.subject.otherHIV-1en_ZA
dc.subject.otherImmune responseen_ZA
dc.subject.otherMycobacterium tuberculosisen_ZA
dc.subject.otherTranscriptome analysisen_ZA
dc.subject.otherGene expressionen_ZA
dc.subject.otherBlooden_ZA
dc.subject.otherInflammationen_ZA
dc.titleIn vivo molecular dissection of the effects of HIV-1 in active tuberculosisen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Bell_In_Vivo_Molecular_Dissection_2016.pdf
Size:
2.47 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles