The effects of clobazam and lorazepam on patient's psychomotor performance and anxiety

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dc.contributor.advisorOxtoby, Richarden_ZA
dc.contributor.authorOblowitz, Howard Keithen_ZA
dc.date.accessioned2014-12-11T20:54:33Z
dc.date.available2014-12-11T20:54:33Z
dc.date.issued1982en_ZA
dc.descriptionBibliography: leaf 162-174.en_ZA
dc.description.abstractPsychomotor performance, drowsiness and anxiety were measured in 70 anxious outpatients in a randomized double-blind, placebo- controlled trial comparing the 1,5 benzodiazepine clobazam (10 mg (two times a day) to lorazepam (1 mg two times a day). Carefully selected tests were administered pre-treatment and at 2 and 9 days after treatment. Compliance was checked by blood assays. There was a significant improvement in anxiety in the clobazam, lorazepam and placebo groups at 2 days and a further improvement at 9 days but only in the clobazam and lorazepam groups. The lorazepam patients had a significantly higher overall drowsiness rating than the clobazam and placebo groups. Both the clobazam and placebo groups showed an improvement over time in choice reaction time, the Digit Symbol Substitution Test, Purdue Pegboard tests and the Inglis paired-associate learning test. There was no change in critical flicker fusion threshold. The lorazepam-treated patients demonstrated exactly the same pattern on psychomotor performance tests except that there was an impairment in two of the Purdue pegboard tests on day 2. On the basis of previous volunteer studies with lorazepam, a far more general and consistent impairment of psychomotor performance was expected with that drug. This indicates that the finding derived from normal volunteers cannot necessarily be extrapolated to anxious patients. The possible reasons for the different responses in volunteers and patients are discussed. The practical implications of the various findings and the recommendations for future research are also considered.en_ZA
dc.identifier.apacitationOblowitz, H. K. (1982). <i>The effects of clobazam and lorazepam on patient's psychomotor performance and anxiety</i>. (Thesis). University of Cape Town ,Faculty of Humanities ,Department of Psychology. Retrieved from http://hdl.handle.net/11427/9967en_ZA
dc.identifier.chicagocitationOblowitz, Howard Keith. <i>"The effects of clobazam and lorazepam on patient's psychomotor performance and anxiety."</i> Thesis., University of Cape Town ,Faculty of Humanities ,Department of Psychology, 1982. http://hdl.handle.net/11427/9967en_ZA
dc.identifier.citationOblowitz, H. 1982. The effects of clobazam and lorazepam on patient's psychomotor performance and anxiety. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Oblowitz, Howard Keith AB - Psychomotor performance, drowsiness and anxiety were measured in 70 anxious outpatients in a randomized double-blind, placebo- controlled trial comparing the 1,5 benzodiazepine clobazam (10 mg (two times a day) to lorazepam (1 mg two times a day). Carefully selected tests were administered pre-treatment and at 2 and 9 days after treatment. Compliance was checked by blood assays. There was a significant improvement in anxiety in the clobazam, lorazepam and placebo groups at 2 days and a further improvement at 9 days but only in the clobazam and lorazepam groups. The lorazepam patients had a significantly higher overall drowsiness rating than the clobazam and placebo groups. Both the clobazam and placebo groups showed an improvement over time in choice reaction time, the Digit Symbol Substitution Test, Purdue Pegboard tests and the Inglis paired-associate learning test. There was no change in critical flicker fusion threshold. The lorazepam-treated patients demonstrated exactly the same pattern on psychomotor performance tests except that there was an impairment in two of the Purdue pegboard tests on day 2. On the basis of previous volunteer studies with lorazepam, a far more general and consistent impairment of psychomotor performance was expected with that drug. This indicates that the finding derived from normal volunteers cannot necessarily be extrapolated to anxious patients. The possible reasons for the different responses in volunteers and patients are discussed. The practical implications of the various findings and the recommendations for future research are also considered. DA - 1982 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 1982 T1 - The effects of clobazam and lorazepam on patient's psychomotor performance and anxiety TI - The effects of clobazam and lorazepam on patient's psychomotor performance and anxiety UR - http://hdl.handle.net/11427/9967 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/9967
dc.identifier.vancouvercitationOblowitz HK. The effects of clobazam and lorazepam on patient's psychomotor performance and anxiety. [Thesis]. University of Cape Town ,Faculty of Humanities ,Department of Psychology, 1982 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/9967en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Psychologyen_ZA
dc.publisher.facultyFaculty of Humanitiesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPsychologyen_ZA
dc.titleThe effects of clobazam and lorazepam on patient's psychomotor performance and anxietyen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMScen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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