The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring

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dc.contributor.advisorHorsnell, Williamen_ZA
dc.contributor.authorMrdjen, Dunjaen_ZA
dc.date.accessioned2014-07-28T14:57:43Z
dc.date.available2014-07-28T14:57:43Z
dc.date.issued2013en_ZA
dc.descriptionIncludes abstract.
dc.descriptionIncludes bibliographical references.
dc.description.abstractThis study investigates imprinting of the murine fetal immune system by maternal infection with the helminth Nippostrongylus brasiliensis (Nb) prior to pregnancy and its effect on control of the Salmonella enterica serovar typhimurium (STm) in offspring. We show that maternal Nb infection in BALB/c mice results in the transfer of Nb antigen (NES)-specific IgG1 in utero and through breastmilk, changes in lymphocyte populations and early germinal center formation in naive offspring. Maternal Nb infection does not interfere with control of STm in offspring in BALB/c mice, but may interfere with control of STm in C57BL/6 mice.en_ZA
dc.identifier.apacitationMrdjen, D. (2013). <i>The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences. Retrieved from http://hdl.handle.net/11427/3175en_ZA
dc.identifier.chicagocitationMrdjen, Dunja. <i>"The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences, 2013. http://hdl.handle.net/11427/3175en_ZA
dc.identifier.citationMrdjen, D. 2013. The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Mrdjen, Dunja AB - This study investigates imprinting of the murine fetal immune system by maternal infection with the helminth Nippostrongylus brasiliensis (Nb) prior to pregnancy and its effect on control of the Salmonella enterica serovar typhimurium (STm) in offspring. We show that maternal Nb infection in BALB/c mice results in the transfer of Nb antigen (NES)-specific IgG1 in utero and through breastmilk, changes in lymphocyte populations and early germinal center formation in naive offspring. Maternal Nb infection does not interfere with control of STm in offspring in BALB/c mice, but may interfere with control of STm in C57BL/6 mice. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring TI - The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring UR - http://hdl.handle.net/11427/3175 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/3175
dc.identifier.vancouvercitationMrdjen D. The influence of maternal Nippostrongylus brasiliensis infection on immunity in offspring. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Clinical Laboratory Sciences, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/3175en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Clinical Laboratory Sciencesen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherClinical Laboratory Sciencesen_ZA
dc.titleThe influence of maternal Nippostrongylus brasiliensis infection on immunity in offspringen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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