Safety of licensed vaccines in HIV-infected persons: a systematic review protocol

Simple item page
dc.contributor.authorKagina, Benjamin M
dc.contributor.authorWiysonge, Charles S
dc.contributor.authorLesosky, Maia
dc.contributor.authorMadhi, Shabir A
dc.contributor.authorHussey, Gregory D
dc.date.accessioned2015-07-30T03:53:24Z
dc.date.available2015-07-30T03:53:24Z
dc.date.issued2014-09-11
dc.date.updated2015-01-15T17:55:34Z
dc.description.abstractAbstract Background Safety of vaccines remains a cornerstone of building public trust on the use of these cost-effective and life-saving public health interventions. In some settings, particularly Sub-Saharan Africa, there is a high prevalence of HIV infection and a high burden of vaccine-preventable diseases. There is evidence suggesting that the immunity induced by some commonly used vaccines is not durable in HIV-infected persons, and therefore, repeated vaccination may be considered to ensure optimal vaccine-induced immunity in this population. However, some vaccines, particularly the live vaccines, may be unsafe in HIV-infected persons. There is lack of evidence on the safety profile of commonly used vaccines among HIV-infected persons. We are therefore conducting a systematic review to assess the safety profile of routine vaccines administered to HIV-infected persons. Methods/Design We will select studies conducted in any setting where licensed and effective vaccines were administered to HIV-infected persons. We will search for eligible studies in PubMed, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, Africa-Wide, PDQ-Evidence and CINAHL as well as reference lists of relevant publications. We will screen search outputs, select studies and extract data in duplicate, resolving discrepancies by discussion and consensus. Discussion Globally, immunisation is a major public health strategy to mitigate morbidity and mortality caused by various infectious disease-causing agents. In general, there are efforts to increase vaccination coverage worldwide, and for these efforts to be successful, safety of the vaccines is paramount, even among people living with HIV, who in some situations may require repeated vaccination. Results from this systematic review will be discussed in the context of the safety of routine vaccines among HIV-infected persons. From the safety perspective, we will also discuss whether repeat vaccination strategies may be feasible among HIV-infected persons. Systematic review registration PROSPERO CRD42014009794 .
dc.identifier.apacitationKagina, B. M., Wiysonge, C. S., Lesosky, M., Madhi, S. A., & Hussey, G. D. (2014). Safety of licensed vaccines in HIV-infected persons: a systematic review protocol. <i>Systematic Reviews</i>, http://hdl.handle.net/11427/13582en_ZA
dc.identifier.chicagocitationKagina, Benjamin M, Charles S Wiysonge, Maia Lesosky, Shabir A Madhi, and Gregory D Hussey "Safety of licensed vaccines in HIV-infected persons: a systematic review protocol." <i>Systematic Reviews</i> (2014) http://hdl.handle.net/11427/13582en_ZA
dc.identifier.citationKagina, B. M., Wiysonge, C. S., Lesosky, M., Madhi, S. A., & Hussey, G. D. (2014). Safety of licensed vaccines in HIV-infected persons: a systematic review protocol. Systematic reviews, 3(1), 101.
dc.identifier.ris TY - Journal Article AU - Kagina, Benjamin M AU - Wiysonge, Charles S AU - Lesosky, Maia AU - Madhi, Shabir A AU - Hussey, Gregory D AB - Abstract Background Safety of vaccines remains a cornerstone of building public trust on the use of these cost-effective and life-saving public health interventions. In some settings, particularly Sub-Saharan Africa, there is a high prevalence of HIV infection and a high burden of vaccine-preventable diseases. There is evidence suggesting that the immunity induced by some commonly used vaccines is not durable in HIV-infected persons, and therefore, repeated vaccination may be considered to ensure optimal vaccine-induced immunity in this population. However, some vaccines, particularly the live vaccines, may be unsafe in HIV-infected persons. There is lack of evidence on the safety profile of commonly used vaccines among HIV-infected persons. We are therefore conducting a systematic review to assess the safety profile of routine vaccines administered to HIV-infected persons. Methods/Design We will select studies conducted in any setting where licensed and effective vaccines were administered to HIV-infected persons. We will search for eligible studies in PubMed, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), Scopus, Africa-Wide, PDQ-Evidence and CINAHL as well as reference lists of relevant publications. We will screen search outputs, select studies and extract data in duplicate, resolving discrepancies by discussion and consensus. Discussion Globally, immunisation is a major public health strategy to mitigate morbidity and mortality caused by various infectious disease-causing agents. In general, there are efforts to increase vaccination coverage worldwide, and for these efforts to be successful, safety of the vaccines is paramount, even among people living with HIV, who in some situations may require repeated vaccination. Results from this systematic review will be discussed in the context of the safety of routine vaccines among HIV-infected persons. From the safety perspective, we will also discuss whether repeat vaccination strategies may be feasible among HIV-infected persons. Systematic review registration PROSPERO CRD42014009794 . DA - 2014-09-11 DB - OpenUCT DO - 10.1186/2046-4053-3-101 DP - University of Cape Town J1 - Systematic Reviews LK - https://open.uct.ac.za PB - University of Cape Town PY - 2014 T1 - Safety of licensed vaccines in HIV-infected persons: a systematic review protocol TI - Safety of licensed vaccines in HIV-infected persons: a systematic review protocol UR - http://hdl.handle.net/11427/13582 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/13582
dc.identifier.urihttp://dx.doi.org/10.1186/2046-4053-3-101
dc.identifier.vancouvercitationKagina BM, Wiysonge CS, Lesosky M, Madhi SA, Hussey GD. Safety of licensed vaccines in HIV-infected persons: a systematic review protocol. Systematic Reviews. 2014; http://hdl.handle.net/11427/13582.en_ZA
dc.language.rfc3066en
dc.publisher.departmentDivision of Medical Microbiologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution License*
dc.rights.holderKagina et al.; licensee BioMed Central Ltd.
dc.rights.urihttp://creativecommons.org/licenses/by/4.0*
dc.sourceSystematic Reviewsen_ZA
dc.source.urihttp://www.systematicreviewsjournal.com
dc.subject.otherVaccination strategiesen_ZA
dc.subject.otherHIVen_ZA
dc.titleSafety of licensed vaccines in HIV-infected persons: a systematic review protocol
dc.typeJournal Articleen_ZA
uct.type.filetype
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Kagina_Safety_vaccines_HIV_2014.pdf
Size:
265.41 KB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.72 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Journal Articles