Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins

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dc.contributor.authorHockman, Dorit
dc.contributor.authorHenderson,Howard E
dc.contributor.authorHockman, Dorit
dc.contributor.authorKastelein, John P
dc.contributor.authorZwinderman, Aeilko H
dc.contributor.authorGagné, Eric
dc.contributor.authorJukema, J Wouter
dc.contributor.authorReymer, Paul W A
dc.contributor.authorGroenemeyer, Björn E
dc.contributor.authorHockman, Dorit
dc.contributor.authorLie, Kong I
dc.contributor.authorBruschke, Albert V G
dc.contributor.authorHayden, Michael R
dc.contributor.authorJansen, Hans
dc.date.accessioned2021-10-08T07:22:53Z
dc.date.available2021-10-08T07:22:53Z
dc.date.issued1999
dc.description.abstractLipoprotein lipase (LPL) is crucial in the hydrolysis of triglycerides (TG) in TG-rich lipoproteins in the formation of HDL particles. As both these lipoproteins play an important role in the pathogenesis of atherosclerotic vascular disease, we sought to assess the relationship between post-heparin LPL (PH-LPL) activity and lipids and lipoproteins in a large, well-defined cohort of Dutch males with coronary artery disease (CAD). These subjects were drawn from the REGRESS study, totaled 730 in number and were evaluated against 75 healthy, normolipidemic male controls. Fasting mean PH-LPL activity in the CAD subjects was 108 46 mU/ml, compared to 138 44 mU/ml in controls (P < 0.0001). When these patients were divided into activity quartiles, those in the lowest versus the highest quartile had higher levels of TG (P < 0.001), VLDLc and VLDL-TG (P = 0.001). Conversely, levels of TC, LDL, and HDLc were lower in these patients (P = 0.001, P = 0.02, and P = 0.001, respectively). Also, in this cohort PH-LPL relationships with lipids and lipoproteins were not altered by apoE genotypes. The frequency of common mutations in the LPL gene associated with partial LPL deficiency (N291S and D9N carriers) in the lowest quartile for LPL activity was more than double the frequency in the highest quartile (12.0% vs. 5.0%; P = 0.006). By contrast, the frequency of the S447X LPL variant rose from 11.5% in the lowest to 18.3% (P = 0.006) in the highest quartile. This study, in a large cohort of CAD patients, has shown that PH-LPL activity is decreased (22%; P = 0.001) when compared to controls; that the D9N and N291S, and S447X LPL variants are genetic determinants, respectively, in CAD patients of low and high LPL PH-LPL activities; and that PH-LPL activity is strongly associated with changes in lipids and lipoproteins.
dc.identifier.apacitationHockman, D., , Hockman, D., Kastelein, J. P., Zwinderman, A. H., Gagné, E., ... Jansen, H. (1999). Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins. <i>The Journal of Lipid Research</i>, 40(4), 735 - 743. http://hdl.handle.net/11427/35018en_ZA
dc.identifier.chicagocitationHockman, Dorit, , Dorit Hockman, John P Kastelein, Aeilko H Zwinderman, Eric Gagné, J Wouter Jukema, et al "Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins." <i>The Journal of Lipid Research</i> 40, 4. (1999): 735 - 743. http://hdl.handle.net/11427/35018en_ZA
dc.identifier.citationHockman, D., , Hockman, D., Kastelein, J.P., Zwinderman, A.H., Gagné, E., Jukema, J.W. & Reymer, P.W.A. et al. 1999. Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins. <i>The Journal of Lipid Research.</i> 40(4):735 - 743. http://hdl.handle.net/11427/35018en_ZA
dc.identifier.issn0022-2275
dc.identifier.issn1539-7262
dc.identifier.ris TY - Journal Article AU - Hockman, Dorit AU - Henderson,Howard E AU - Hockman, Dorit AU - Kastelein, John P AU - Zwinderman, Aeilko H AU - Gagné, Eric AU - Jukema, J Wouter AU - Reymer, Paul W A AU - Groenemeyer, Björn E AU - Hockman, Dorit AU - Lie, Kong I AU - Bruschke, Albert V G AU - Hayden, Michael R AU - Jansen, Hans AB - Lipoprotein lipase (LPL) is crucial in the hydrolysis of triglycerides (TG) in TG-rich lipoproteins in the formation of HDL particles. As both these lipoproteins play an important role in the pathogenesis of atherosclerotic vascular disease, we sought to assess the relationship between post-heparin LPL (PH-LPL) activity and lipids and lipoproteins in a large, well-defined cohort of Dutch males with coronary artery disease (CAD). These subjects were drawn from the REGRESS study, totaled 730 in number and were evaluated against 75 healthy, normolipidemic male controls. Fasting mean PH-LPL activity in the CAD subjects was 108 46 mU/ml, compared to 138 44 mU/ml in controls (P < 0.0001). When these patients were divided into activity quartiles, those in the lowest versus the highest quartile had higher levels of TG (P < 0.001), VLDLc and VLDL-TG (P = 0.001). Conversely, levels of TC, LDL, and HDLc were lower in these patients (P = 0.001, P = 0.02, and P = 0.001, respectively). Also, in this cohort PH-LPL relationships with lipids and lipoproteins were not altered by apoE genotypes. The frequency of common mutations in the LPL gene associated with partial LPL deficiency (N291S and D9N carriers) in the lowest quartile for LPL activity was more than double the frequency in the highest quartile (12.0% vs. 5.0%; P = 0.006). By contrast, the frequency of the S447X LPL variant rose from 11.5% in the lowest to 18.3% (P = 0.006) in the highest quartile. This study, in a large cohort of CAD patients, has shown that PH-LPL activity is decreased (22%; P = 0.001) when compared to controls; that the D9N and N291S, and S447X LPL variants are genetic determinants, respectively, in CAD patients of low and high LPL PH-LPL activities; and that PH-LPL activity is strongly associated with changes in lipids and lipoproteins. DA - 1999 DB - OpenUCT DP - University of Cape Town IS - 4 J1 - The Journal of Lipid Research LK - https://open.uct.ac.za PY - 1999 SM - 0022-2275 SM - 1539-7262 T1 - Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins TI - Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins UR - http://hdl.handle.net/11427/35018 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/35018
dc.identifier.vancouvercitationHockman D, , Hockman D, Kastelein JP, Zwinderman AH, Gagné E, et al. Lipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins. The Journal of Lipid Research. 1999;40(4):735 - 743. http://hdl.handle.net/11427/35018.en_ZA
dc.language.isoeng
dc.publisher.departmentDivision of Chemical Pathology
dc.publisher.facultyFaculty of Health Sciences
dc.sourceThe Journal of Lipid Research
dc.source.journalissue4
dc.source.journalvolume40
dc.source.pagination735 - 743
dc.source.urihttps://dx.doi.org/10.7196/sajs.718
dc.subject.otherAdult
dc.subject.otherApolipoproteins E
dc.subject.otherCholesterol
dc.subject.otherCohort Studies
dc.subject.otherCoronary Disease
dc.subject.otherDouble-Blind Method
dc.subject.otherFasting
dc.subject.otherHumans
dc.subject.otherLipids
dc.subject.otherLipoprotein Lipase
dc.subject.otherLipoproteins
dc.subject.otherMale
dc.subject.otherMiddle Aged
dc.subject.otherMutation
dc.subject.otherPlacebos
dc.subject.otherReference Values
dc.subject.otherTriglycerides
dc.titleLipoprotein lipase activity is decreased in a large cohort of patients with coronary artery disease and is associated with changes in lipids and lipoproteins
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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