Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain [greater than or equal to]14days): Pierrea multi-country, prospective, non-experimental case-control study

Simple item page
dc.contributor.authorPolman, Katjaen_ZA
dc.contributor.authorBecker, Sorenen_ZA
dc.contributor.authorAlirol, Emilieen_ZA
dc.contributor.authorBhatta, Nishaen_ZA
dc.contributor.authorBhattarai, Narayanen_ZA
dc.contributor.authorBottieau, Emmanuelen_ZA
dc.contributor.authorBratschi, Martinen_ZA
dc.contributor.authorBurza, Sakiben_ZA
dc.contributor.authorCoulibaly, Jeanen_ZA
dc.contributor.authorDoumbia, Mamaen_ZA
dc.contributor.authorHorie, Ninonen_ZA
dc.contributor.authorJacobs, Janen_ZA
dc.contributor.authorKhanal, Basudhaen_ZA
dc.contributor.authorLandoure, Alyen_ZA
dc.contributor.authorMahendradhata, Yodien_ZA
dc.contributor.authorMeheuen_ZA
dc.date.accessioned2015-12-07T08:53:18Z
dc.date.available2015-12-07T08:53:18Z
dc.date.issued2015en_ZA
dc.description.abstractBACKGROUND: Diarrhoea still accounts for considerable mortality and morbidity worldwide. The highest burden is concentrated in tropical areas where populations lack access to clean water, adequate sanitation and hygiene. In contrast to acute diarrhoea (<14days), the spectrum of pathogens that may give rise to persistent diarrhoea ([greater than or equal to]14days) and persistent abdominal pain is poorly understood. It is conceivable that pathogens causing neglected tropical diseases play a major role, but few studies investigated this issue. Clinical management and diagnostic work-up of persistent digestive disorders in the tropics therefore remain inadequate. Hence, important aspects regarding the pathogenesis, epidemiology, clinical symptomatology and treatment options for patients presenting with persistent diarrhoea and persistent abdominal pain should be investigated in multi-centric clinical studies.METHODS/DESIGN:This multi-country, prospective, non-experimental case-control study will assess persistent diarrhoea ([greater than or equal to]14days; in individuals aged [greater than or equal to]1year) and persistent abdominal pain ([greater than or equal to]14days; in children/adolescents aged 1-18 years) in up to 2000 symptomatic patients and 2000 matched controls. Subjects from Cote d'Ivoire, Indonesia, Mali and Nepal will be clinically examined and interviewed using a detailed case report form. Additionally, each participant will provide a stool sample that will be examined using a suite of diagnostic methods (i.e., microscopic techniques, rapid diagnostic tests, stool culture and polymerase chain reaction) for the presence of bacterial and parasitic pathogens. Treatment will be offered to all infected participants and the clinical treatment response will be recorded. Data obtained will be utilised to develop patient-centred clinical algorithms that will be validated in primary health care centres in the four study countries in subsequent studies.DISCUSSION:Our research will deepen the understanding of the importance of persistent diarrhoea and related digestive disorders in the tropics. A diversity of intestinal pathogens will be assessed for potential associations with persistent diarrhoea and persistent abdominal pain. Different diagnostic methods will be compared, clinical symptoms investigated and diagnosis-treatment algorithms developed for validation in selected primary health care centres. The findings from this study will improve differential diagnosis and evidence-based clinical management of digestive syndromes in the tropics.TRIAL REGISTRATION:ClinicalTrials.gov; identifier: NCT02105714.en_ZA
dc.identifier.apacitationPolman, K., Becker, S., Alirol, E., Bhatta, N., Bhattarai, N., Bottieau, E., ... (2015). Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain [greater than or equal to]14days): Pierrea multi-country, prospective, non-experimental case-control study. <i>BMC Infectious Diseases</i>, http://hdl.handle.net/11427/15663en_ZA
dc.identifier.chicagocitationPolman, Katja, Soren Becker, Emilie Alirol, Nisha Bhatta, Narayan Bhattarai, Emmanuel Bottieau, Martin Bratschi, et al "Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain [greater than or equal to]14days): Pierrea multi-country, prospective, non-experimental case-control study." <i>BMC Infectious Diseases</i> (2015) http://hdl.handle.net/11427/15663en_ZA
dc.identifier.citationPolman, K., Becker, S. L., Alirol, E., Bhatta, N. K., Bhattarai, N. R., Bottieau, E., ... & Utzinger, J. (2015). Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain≥ 14 days): Pierrea multi-country, prospective, non-experimental case–control study. BMC infectious diseases, 15(1), 338.en_ZA
dc.identifier.ris TY - Journal Article AU - Polman, Katja AU - Becker, Soren AU - Alirol, Emilie AU - Bhatta, Nisha AU - Bhattarai, Narayan AU - Bottieau, Emmanuel AU - Bratschi, Martin AU - Burza, Sakib AU - Coulibaly, Jean AU - Doumbia, Mama AU - Horie, Ninon AU - Jacobs, Jan AU - Khanal, Basudha AU - Landoure, Aly AU - Mahendradhata, Yodi AU - Meheu AB - BACKGROUND: Diarrhoea still accounts for considerable mortality and morbidity worldwide. The highest burden is concentrated in tropical areas where populations lack access to clean water, adequate sanitation and hygiene. In contrast to acute diarrhoea (<14days), the spectrum of pathogens that may give rise to persistent diarrhoea ([greater than or equal to]14days) and persistent abdominal pain is poorly understood. It is conceivable that pathogens causing neglected tropical diseases play a major role, but few studies investigated this issue. Clinical management and diagnostic work-up of persistent digestive disorders in the tropics therefore remain inadequate. Hence, important aspects regarding the pathogenesis, epidemiology, clinical symptomatology and treatment options for patients presenting with persistent diarrhoea and persistent abdominal pain should be investigated in multi-centric clinical studies.METHODS/DESIGN:This multi-country, prospective, non-experimental case-control study will assess persistent diarrhoea ([greater than or equal to]14days; in individuals aged [greater than or equal to]1year) and persistent abdominal pain ([greater than or equal to]14days; in children/adolescents aged 1-18 years) in up to 2000 symptomatic patients and 2000 matched controls. Subjects from Cote d'Ivoire, Indonesia, Mali and Nepal will be clinically examined and interviewed using a detailed case report form. Additionally, each participant will provide a stool sample that will be examined using a suite of diagnostic methods (i.e., microscopic techniques, rapid diagnostic tests, stool culture and polymerase chain reaction) for the presence of bacterial and parasitic pathogens. Treatment will be offered to all infected participants and the clinical treatment response will be recorded. Data obtained will be utilised to develop patient-centred clinical algorithms that will be validated in primary health care centres in the four study countries in subsequent studies.DISCUSSION:Our research will deepen the understanding of the importance of persistent diarrhoea and related digestive disorders in the tropics. A diversity of intestinal pathogens will be assessed for potential associations with persistent diarrhoea and persistent abdominal pain. Different diagnostic methods will be compared, clinical symptoms investigated and diagnosis-treatment algorithms developed for validation in selected primary health care centres. The findings from this study will improve differential diagnosis and evidence-based clinical management of digestive syndromes in the tropics.TRIAL REGISTRATION:ClinicalTrials.gov; identifier: NCT02105714. DA - 2015 DB - OpenUCT DO - 10.1186/s12879-015-1074-x DP - University of Cape Town J1 - BMC Infectious Diseases LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain [greater than or equal to]14days): Pierrea multi-country, prospective, non-experimental case-control study TI - Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain [greater than or equal to]14days): Pierrea multi-country, prospective, non-experimental case-control study UR - http://hdl.handle.net/11427/15663 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15663
dc.identifier.urihttp://dx.doi.org/10.1186/s12879-015-1074-x
dc.identifier.vancouvercitationPolman K, Becker S, Alirol E, Bhatta N, Bhattarai N, Bottieau E, et al. Diagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain [greater than or equal to]14days): Pierrea multi-country, prospective, non-experimental case-control study. BMC Infectious Diseases. 2015; http://hdl.handle.net/11427/15663.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2015 Polman et al.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourceBMC Infectious Diseasesen_ZA
dc.source.urihttp://www.biomedcentral.com/bmcinfectdis/en_ZA
dc.subject.otherBacteriaen_ZA
dc.subject.otherDiagnosis-treatment algorithmen_ZA
dc.subject.otherHelminthsen_ZA
dc.subject.otherIntestinal protozoaen_ZA
dc.subject.otherNeglected tropical diseasesen_ZA
dc.subject.otherPersistent diarrhoeaen_ZA
dc.subject.otherCôte d’Ivoireen_ZA
dc.subject.otherIndonesiaen_ZA
dc.subject.otherMalien_ZA
dc.subject.otherNepalen_ZA
dc.titleDiagnosis of neglected tropical diseases among patients with persistent digestive disorders (diarrhoea and/or abdominal pain [greater than or equal to]14days): Pierrea multi-country, prospective, non-experimental case-control studyen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Polman_Diagnosis_neglected_tropical_diseases_2015.pdf
Size:
1.73 MB
Format:
Adobe Portable Document Format
Description:
Download
Collections
Journal Articles