An investigation of the role of N102 of the GnRH receptor in determining the potency of C-terminally modified agonist analogs
Master Thesis
2000
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University of Cape Town
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Abstract
Three GnRH receptors with the mutations N102A, N102D and N102K, which were derived from the human GnRH receptor by site directed mutagenesis, were expressed in COS-1 cells. The effects of these mutations on the potency of seven C-terminally modified GnRH agonist analogs for the stimulation of IP production were determined.
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Bibliography : leaves 84-104.
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Henshall-Howard, M. 2000. An investigation of the role of N102 of the GnRH receptor in determining the potency of C-terminally modified agonist analogs. University of Cape Town.