Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population

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dc.contributor.advisorTodd, Gailen_ZA
dc.contributor.advisorKatz, Arieh Aen_ZA
dc.contributor.authorIsaacs, Thurayaen_ZA
dc.date.accessioned2017-09-22T11:58:13Z
dc.date.available2017-09-22T11:58:13Z
dc.date.issued2017en_ZA
dc.description.abstractHuman herpes virus 8 (HHV8) is the aetiological agent of all forms of Kaposi's sarcoma (KS). Seven major subtypes (A, B, C, D, E, F, Z) based on genetic variability of open reading frame (ORF)-K1, have been identified. Numerous studies point to differing tumorigenic and pathogenic properties of the HHV8 subtypes. The study objective was to determine the prevalence of the HHV8 subtypes in a cohort of clinical and histologically confirmed KS in Cape Town, South Africa, and analyse associations between the different subtypes, clinico- epidemiological forms and clinical presentation of KS. The clinical data was prospectively collected and recorded on a body diagram and with photographs. Demographic data was retrospectively collected from clinical records. Tissue biopsies were taken for ORF-K1 subtyping. Out of a cohort of 103, eighty six patients were subtyped; 81 AIDS (aquired immune deficiency syndrome)-KS and 5 African endemic. Subtype A5 (42/86) and B2 (16/86) predominated. B1, B3, A1 and A4 subtypes were identified in 10/86, 9/86, 4/86 and 1/86 patients respectively. A5, B1, B2 and B3 were found in African blacks and individuals of mixed ancestry, while subtypes A1 and A4 are found only in whites and individuals of mixed ancestry. Subtype A5 was associated with >10 KS lesions at presentation in the AIDS-cohort (32/38, p=0,050), but not in the African endemic patients (2/4, p=0,600). Subtypes A1 and A4 were less likely to be associated with poor risk tumour extension (p=0,031) and A1 was associated with lower likelihood of lower limb involvement (p=0,004).en_ZA
dc.identifier.apacitationIsaacs, T. (2017). <i>Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Dermatology. Retrieved from http://hdl.handle.net/11427/25281en_ZA
dc.identifier.chicagocitationIsaacs, Thuraya. <i>"Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Dermatology, 2017. http://hdl.handle.net/11427/25281en_ZA
dc.identifier.citationIsaacs, T. 2017. Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Isaacs, Thuraya AB - Human herpes virus 8 (HHV8) is the aetiological agent of all forms of Kaposi's sarcoma (KS). Seven major subtypes (A, B, C, D, E, F, Z) based on genetic variability of open reading frame (ORF)-K1, have been identified. Numerous studies point to differing tumorigenic and pathogenic properties of the HHV8 subtypes. The study objective was to determine the prevalence of the HHV8 subtypes in a cohort of clinical and histologically confirmed KS in Cape Town, South Africa, and analyse associations between the different subtypes, clinico- epidemiological forms and clinical presentation of KS. The clinical data was prospectively collected and recorded on a body diagram and with photographs. Demographic data was retrospectively collected from clinical records. Tissue biopsies were taken for ORF-K1 subtyping. Out of a cohort of 103, eighty six patients were subtyped; 81 AIDS (aquired immune deficiency syndrome)-KS and 5 African endemic. Subtype A5 (42/86) and B2 (16/86) predominated. B1, B3, A1 and A4 subtypes were identified in 10/86, 9/86, 4/86 and 1/86 patients respectively. A5, B1, B2 and B3 were found in African blacks and individuals of mixed ancestry, while subtypes A1 and A4 are found only in whites and individuals of mixed ancestry. Subtype A5 was associated with >10 KS lesions at presentation in the AIDS-cohort (32/38, p=0,050), but not in the African endemic patients (2/4, p=0,600). Subtypes A1 and A4 were less likely to be associated with poor risk tumour extension (p=0,031) and A1 was associated with lower likelihood of lower limb involvement (p=0,004). DA - 2017 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2017 T1 - Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population TI - Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population UR - http://hdl.handle.net/11427/25281 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/25281
dc.identifier.vancouvercitationIsaacs T. Kaposi's sarcoma: Genetic subtypes and clinical correlation in a South African population. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Dermatology, 2017 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/25281en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Dermatologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherDermatologyen_ZA
dc.titleKaposi's sarcoma: Genetic subtypes and clinical correlation in a South African populationen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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