Obesity phenotypes in urban and rural Cameroonians: a cross-sectional study

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dc.contributor.authorMbanya, Vivianen_ZA
dc.contributor.authorEchouffo-Tcheugui, Justinen_ZA
dc.contributor.authorAkhtar, Hussainen_ZA
dc.contributor.authorMbanya, Jean-Claudeen_ZA
dc.contributor.authorKengne, Andreen_ZA
dc.date.accessioned2015-12-07T08:52:14Z
dc.date.available2015-12-07T08:52:14Z
dc.date.issued2015en_ZA
dc.description.abstractBACKGROUND: Despite the increasing prevalence of diabetes and other health consequences of obesity, little is known on the metabolic profile across categories of body mass index (BMI) among African populations. We therefore assessed the prevalence and distribution of body size phenotypes among urban and rural Cameroonians. METHODS: Adults (n=1628; 41% rural dwellers) aged 24-74 years in 1994 provided data on BMI and metabolic health, defined on the basis of elevated levels of blood pressure (BP); triglycerides, fasting plasma glucose (FPG), and insulin resistance as assessed with homeostasis model assessment (HOMA). Cross-classification of BMI categories and metabolic status (healthy/unhealthy) created six groups. Metabolic measures include elevated blood pressure; elevated triglycerides ([greater than or equal to]150 mg/dL or 1.69mmo/L), elevated fasting plasma glucose ([greater than or equal to]100 mg/dl or 5.6 mmol/L or documented use of antidiabetic medications), and elevated homeostasis model assessment of insulin resistance value (HOMA-IR>90th percentile). RESULTS: A total of 25.2% of participants were overweight yet metabolically healthy (<1 abnormality) and 10.1% were obese yet metabolically healthy, whereas 1.4% were normal weight but metabolically abnormal ([greater than or equal to]2 abnormalities). Proportion of rural dwellers with abnormal metabolic phenotype across normal-weight, overweight, obese categories were 2.9%, 0.8% and 0.3%, respectively; and 0 .3%, 2.2% and 2.6% among urban dwellers. Metabolically abnormal participants increased linearly across BMI categories (p<0.001). BMI categories and metabolic status interacted to affect age, gender, BMI, FPG, triglycerides, and BP status distributions (all p<0.04). Metabolic status and residence (rural vs. urban) interacted to influence the distribution across BMI categories of diastolic BP, BMI, waist circumference, fasting and 2-hour glucose, triglycerides, HOMA-IR, and prevalent diabetes (all p<0.005), with differential occurrence of BMI categories and metabolic status among urban and rural participants. CONCLUSIONS: Metabolic healthy obesity and obesity with a favorable cardiometabolic profile are not uncommon among Cameroonians, including among rural dwellers; but the latter group tended to have a better profile.en_ZA
dc.identifier.apacitationMbanya, V., Echouffo-Tcheugui, J., Akhtar, H., Mbanya, J., & Kengne, A. (2015). Obesity phenotypes in urban and rural Cameroonians: a cross-sectional study. <i>Diabetology & Metabolic Syndrome</i>, http://hdl.handle.net/11427/15655en_ZA
dc.identifier.chicagocitationMbanya, Vivian, Justin Echouffo-Tcheugui, Hussain Akhtar, Jean-Claude Mbanya, and Andre Kengne "Obesity phenotypes in urban and rural Cameroonians: a cross-sectional study." <i>Diabetology & Metabolic Syndrome</i> (2015) http://hdl.handle.net/11427/15655en_ZA
dc.identifier.citationMbanya, V. N., Echouffo-Tcheugui, J. B., Akhtar, H., Mbanya, J. C., & Kengne, A. P. (2015). Obesity phenotypes in urban and rural Cameroonians: a cross-sectional study. Diabetology & metabolic syndrome, 7(1), 21.en_ZA
dc.identifier.ris TY - Journal Article AU - Mbanya, Vivian AU - Echouffo-Tcheugui, Justin AU - Akhtar, Hussain AU - Mbanya, Jean-Claude AU - Kengne, Andre AB - BACKGROUND: Despite the increasing prevalence of diabetes and other health consequences of obesity, little is known on the metabolic profile across categories of body mass index (BMI) among African populations. We therefore assessed the prevalence and distribution of body size phenotypes among urban and rural Cameroonians. METHODS: Adults (n=1628; 41% rural dwellers) aged 24-74 years in 1994 provided data on BMI and metabolic health, defined on the basis of elevated levels of blood pressure (BP); triglycerides, fasting plasma glucose (FPG), and insulin resistance as assessed with homeostasis model assessment (HOMA). Cross-classification of BMI categories and metabolic status (healthy/unhealthy) created six groups. Metabolic measures include elevated blood pressure; elevated triglycerides ([greater than or equal to]150 mg/dL or 1.69mmo/L), elevated fasting plasma glucose ([greater than or equal to]100 mg/dl or 5.6 mmol/L or documented use of antidiabetic medications), and elevated homeostasis model assessment of insulin resistance value (HOMA-IR>90th percentile). RESULTS: A total of 25.2% of participants were overweight yet metabolically healthy (<1 abnormality) and 10.1% were obese yet metabolically healthy, whereas 1.4% were normal weight but metabolically abnormal ([greater than or equal to]2 abnormalities). Proportion of rural dwellers with abnormal metabolic phenotype across normal-weight, overweight, obese categories were 2.9%, 0.8% and 0.3%, respectively; and 0 .3%, 2.2% and 2.6% among urban dwellers. Metabolically abnormal participants increased linearly across BMI categories (p<0.001). BMI categories and metabolic status interacted to affect age, gender, BMI, FPG, triglycerides, and BP status distributions (all p<0.04). Metabolic status and residence (rural vs. urban) interacted to influence the distribution across BMI categories of diastolic BP, BMI, waist circumference, fasting and 2-hour glucose, triglycerides, HOMA-IR, and prevalent diabetes (all p<0.005), with differential occurrence of BMI categories and metabolic status among urban and rural participants. CONCLUSIONS: Metabolic healthy obesity and obesity with a favorable cardiometabolic profile are not uncommon among Cameroonians, including among rural dwellers; but the latter group tended to have a better profile. DA - 2015 DB - OpenUCT DO - 10.1186/s13098-015-0016-5 DP - University of Cape Town J1 - Diabetology & Metabolic Syndrome LK - https://open.uct.ac.za PB - University of Cape Town PY - 2015 T1 - Obesity phenotypes in urban and rural Cameroonians: a cross-sectional study TI - Obesity phenotypes in urban and rural Cameroonians: a cross-sectional study UR - http://hdl.handle.net/11427/15655 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15655
dc.identifier.urihttp://dx.doi.org/10.1186/s13098-015-0016-5
dc.identifier.vancouvercitationMbanya V, Echouffo-Tcheugui J, Akhtar H, Mbanya J, Kengne A. Obesity phenotypes in urban and rural Cameroonians: a cross-sectional study. Diabetology & Metabolic Syndrome. 2015; http://hdl.handle.net/11427/15655.en_ZA
dc.language.isoengen_ZA
dc.publisherBioMed Central Ltden_ZA
dc.publisher.departmentDepartment of Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an Open Access article distributed under the terms of the Creative Commons Attribution Licenseen_ZA
dc.rights.holder2015 Mbanya et al.; licensee BioMed Central.en_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourceDiabetology & Metabolic Syndromeen_ZA
dc.source.urihttp://www.dmsjournal.com/en_ZA
dc.subject.otherdiabetesen_ZA
dc.subject.otherobesityen_ZA
dc.titleObesity phenotypes in urban and rural Cameroonians: a cross-sectional studyen_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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