Is obesity a risk factor for vaccine non-responsiveness?

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dc.contributor.authorYoung, Katherine Men_ZA
dc.contributor.authorGray, Clive Men_ZA
dc.contributor.authorBekker, Linda-Gailen_ZA
dc.date.accessioned2015-11-23T12:25:39Z
dc.date.available2015-11-23T12:25:39Z
dc.date.issued2013en_ZA
dc.description.abstractUnderstanding the link between vaccine immunogenicity and efficacy is currently a major focus in HIV research. Consequently, recent developments in the HIV-1 vaccine field have led to a closer look at immune responses to known efficacious vaccines. We undertook a study to explore clinical predictors of vaccine efficacy following recombinant hepatitis B (rHBV) vaccination in a cohort of HIV-uninfected, hepatitis B virus naïve women living in a peri-urban setting in Cape Town. Our aim was to define host biological risk factors associated with lack of vaccine uptake. We found a significant association (p=0.009) between body mass index (BMI) and lack of vaccine-specific IgG titre (<10mIU/mL). Obese individuals (BMI ≥ 30kg/m 2 ) were significantly more likely to be non-responders following 2 rHBV vaccine doses (Adjusted Odds Ratio of 8.75; p=0.043). There was no observed association between vaccine responses and age, method of contraception or time from vaccination to antibody measurement. These data suggest that obesity-associated factors interfere with vaccine immunogenicity and possible efficacy.en_ZA
dc.identifier.apacitationYoung, K. M., Gray, C. M., & Bekker, L. (2013). Is obesity a risk factor for vaccine non-responsiveness?. <i>PLoS One</i>, http://hdl.handle.net/11427/15275en_ZA
dc.identifier.chicagocitationYoung, Katherine M, Clive M Gray, and Linda-Gail Bekker "Is obesity a risk factor for vaccine non-responsiveness?." <i>PLoS One</i> (2013) http://hdl.handle.net/11427/15275en_ZA
dc.identifier.citationYoung, K. M., Gray, C. M., & Bekker, L. G. (2012). Is obesity a risk factor for vaccine non-responsiveness?. PloS one, 8(12), e82779. doi:10.1371/journal.pone.0082779en_ZA
dc.identifier.ris TY - Journal Article AU - Young, Katherine M AU - Gray, Clive M AU - Bekker, Linda-Gail AB - Understanding the link between vaccine immunogenicity and efficacy is currently a major focus in HIV research. Consequently, recent developments in the HIV-1 vaccine field have led to a closer look at immune responses to known efficacious vaccines. We undertook a study to explore clinical predictors of vaccine efficacy following recombinant hepatitis B (rHBV) vaccination in a cohort of HIV-uninfected, hepatitis B virus naïve women living in a peri-urban setting in Cape Town. Our aim was to define host biological risk factors associated with lack of vaccine uptake. We found a significant association (p=0.009) between body mass index (BMI) and lack of vaccine-specific IgG titre (<10mIU/mL). Obese individuals (BMI ≥ 30kg/m 2 ) were significantly more likely to be non-responders following 2 rHBV vaccine doses (Adjusted Odds Ratio of 8.75; p=0.043). There was no observed association between vaccine responses and age, method of contraception or time from vaccination to antibody measurement. These data suggest that obesity-associated factors interfere with vaccine immunogenicity and possible efficacy. DA - 2013 DB - OpenUCT DO - 10.1371/journal.pone.0082779 DP - University of Cape Town J1 - PLoS One LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Is obesity a risk factor for vaccine non-responsiveness? TI - Is obesity a risk factor for vaccine non-responsiveness? UR - http://hdl.handle.net/11427/15275 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/15275
dc.identifier.urihttp://dx.doi.org/10.1371/journal.pone.0082779
dc.identifier.vancouvercitationYoung KM, Gray CM, Bekker L. Is obesity a risk factor for vaccine non-responsiveness?. PLoS One. 2013; http://hdl.handle.net/11427/15275.en_ZA
dc.language.isoengen_ZA
dc.publisherPublic Library of Scienceen_ZA
dc.publisher.departmentDesmond Tutu HIV Centreen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.rightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_ZA
dc.rights.holder© 2013 Young et alen_ZA
dc.rights.urihttp://creativecommons.org/licenses/by/4.0en_ZA
dc.sourcePLoS Oneen_ZA
dc.source.urihttp://journals.plos.org/plosoneen_ZA
dc.subject.otherVaccinesen_ZA
dc.subject.otherHIV vaccinesen_ZA
dc.subject.otherBody mass indexen_ZA
dc.subject.otherObesityen_ZA
dc.subject.otherVaccination and immunizationen_ZA
dc.subject.otherVaccine developmenten_ZA
dc.subject.otherHIV-1en_ZA
dc.subject.otherHIVen_ZA
dc.titleIs obesity a risk factor for vaccine non-responsiveness?en_ZA
dc.typeJournal Articleen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceArticleen_ZA
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