Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes

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dc.contributor.authorHockman, Dorit
dc.contributor.authorBurns, Alan J
dc.contributor.authorSchlosser, Gerhard
dc.contributor.authorGates, Keith P
dc.contributor.authorJevans, Benjamin
dc.contributor.authorMongera, Alessandro
dc.contributor.authorFisher, Shannon
dc.contributor.authorUnlu, Gokhan
dc.contributor.authorKnapik, Ela W
dc.contributor.authorKaufman, Charles K
dc.contributor.authorMosimann, Christian
dc.contributor.authorZon, Leonard I
dc.contributor.authorLancman, Joseph J
dc.contributor.authorDong, P Duc S
dc.contributor.authorLickert, Heiko
dc.contributor.authorTucker, Abigail S
dc.contributor.authorBaker, Clare V H
dc.date.accessioned2021-10-08T07:04:04Z
dc.date.available2021-10-08T07:04:04Z
dc.date.issued2017
dc.description.abstractThe evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes – carotid body glomus cells, and ‘pulmonary neuroendocrine cells’ (PNECs) - are obscure. Homology has been proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive ‘neuroepithelial cells’ (NECs) of fish gills, whose embryonic origin is unknown. NECs have also been likened to PNECs, which differentiate in situ within lung airway epithelia. Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate-mapping in frog and lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs, whose endodermal origin we confirm. We discover neural crest-derived catecholaminergic cells associated with zebrafish pharyngeal arch blood vessels, and propose a new model for amniote hypoxia-sensitive cell evolution: endoderm-derived NECs were retained as PNECs, while the carotid body evolved via the aggregation of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels in anamniote pharyngeal arches.
dc.identifier.apacitationHockman, D., Burns, A. J., Schlosser, G., Gates, K. P., Jevans, B., Mongera, A., ... Baker, C. V. H. (2017). Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. <i>ELife</i>, 6(4), 174 - 177. http://hdl.handle.net/11427/34417en_ZA
dc.identifier.chicagocitationHockman, Dorit, Alan J Burns, Gerhard Schlosser, Keith P Gates, Benjamin Jevans, Alessandro Mongera, Shannon Fisher, et al "Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes." <i>ELife</i> 6, 4. (2017): 174 - 177. http://hdl.handle.net/11427/34417en_ZA
dc.identifier.citationHockman, D., Burns, A.J., Schlosser, G., Gates, K.P., Jevans, B., Mongera, A., Fisher, S. & Unlu, G. et al. 2017. Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. <i>ELife.</i> 6(4):174 - 177. http://hdl.handle.net/11427/34417en_ZA
dc.identifier.issn2050-084X
dc.identifier.ris TY - Journal Article AU - Hockman, Dorit AU - Burns, Alan J AU - Schlosser, Gerhard AU - Gates, Keith P AU - Jevans, Benjamin AU - Mongera, Alessandro AU - Fisher, Shannon AU - Unlu, Gokhan AU - Knapik, Ela W AU - Kaufman, Charles K AU - Mosimann, Christian AU - Zon, Leonard I AU - Lancman, Joseph J AU - Dong, P Duc S AU - Lickert, Heiko AU - Tucker, Abigail S AU - Baker, Clare V H AB - The evolutionary origins of the hypoxia-sensitive cells that trigger amniote respiratory reflexes – carotid body glomus cells, and ‘pulmonary neuroendocrine cells’ (PNECs) - are obscure. Homology has been proposed between glomus cells, which are neural crest-derived, and the hypoxia-sensitive ‘neuroepithelial cells’ (NECs) of fish gills, whose embryonic origin is unknown. NECs have also been likened to PNECs, which differentiate in situ within lung airway epithelia. Using genetic lineage-tracing and neural crest-deficient mutants in zebrafish, and physical fate-mapping in frog and lamprey, we find that NECs are not neural crest-derived, but endoderm-derived, like PNECs, whose endodermal origin we confirm. We discover neural crest-derived catecholaminergic cells associated with zebrafish pharyngeal arch blood vessels, and propose a new model for amniote hypoxia-sensitive cell evolution: endoderm-derived NECs were retained as PNECs, while the carotid body evolved via the aggregation of neural crest-derived catecholaminergic (chromaffin) cells already associated with blood vessels in anamniote pharyngeal arches. DA - 2017 DB - OpenUCT DP - University of Cape Town IS - 4 J1 - ELife LK - https://open.uct.ac.za PY - 2017 SM - 2050-084X T1 - Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes TI - Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes UR - http://hdl.handle.net/11427/34417 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/34417
dc.identifier.vancouvercitationHockman D, Burns AJ, Schlosser G, Gates KP, Jevans B, Mongera A, et al. Evolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes. ELife. 2017;6(4):174 - 177. http://hdl.handle.net/11427/34417.en_ZA
dc.language.isoeng
dc.publisher.departmentDepartment of Molecular and Cell Biology
dc.publisher.facultyFaculty of Science
dc.sourceELife
dc.source.journalissue4
dc.source.journalvolume6
dc.source.pagination174 - 177
dc.source.urihttps://dx.doi.org/10.7554/eLife.21231
dc.subject.otherScience &
dc.subject.otherTechnology
dc.subject.otherLife Sciences &
dc.subject.otherBiomedicine
dc.subject.otherBiology
dc.subject.otherLife Sciences &
dc.subject.otherBiomedicine - Other Topics
dc.subject.otherPULMONARY NEUROENDOCRINE CELLS
dc.subject.otherGILL NEUROEPITHELIAL CELLS
dc.subject.otherNEURAL CREST CONTRIBUTIONS
dc.subject.otherCAROTID-BODY
dc.subject.otherXENOPUS-LAEVIS
dc.subject.otherARTERIAL CHEMORECEPTORS
dc.subject.otherPROGENITOR CELLS
dc.subject.otherCATECHOLAMINE RESPONSE
dc.subject.otherOXYGEN CHEMORECEPTORS
dc.subject.otherZEBRAFISH CORNEA
dc.titleEvolution of the hypoxia-sensitive cells involved in amniote respiratory reflexes
dc.typeJournal Article
uct.type.publicationResearch
uct.type.resourceJournal Article
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