Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients

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dc.contributor.advisorDheda, Keertanen_ZA
dc.contributor.advisorPeter, Jonathan Gen_ZA
dc.contributor.advisorRandall, Philippaen_ZA
dc.contributor.authorGina, Ntombenhle Phindileen_ZA
dc.date.accessioned2016-07-27T10:13:35Z
dc.date.available2016-07-27T10:13:35Z
dc.date.issued2016en_ZA
dc.description.abstractPoint-of-care detection of urine lipoarabinomannan (LAM) is a low-cost rapid TB diagnostic for use in HIV co-infected patients. However, its sensitivity in these patients is suboptimal. Strategies to improve its performance is a need. The hypothesis was that early morning urine (EMU), rather than random urine sampling, would improve LAM's sensitivity. Methods Recruitment process conducted between June 2012 and February 2014 for HIV-infected patients from four hospitals in Cape Town, South Africa presenting with possible TB (all patients initiated on TB treatment). Fresh random and early morning urine (EMU) samples (~10-30 ml) collected in sterile containers. Following the manufacturer's instructions, an Alere Determine® TB Lateral flow assay performed on each sample, using both grade 1 and 2 cut-points. A single sputum Xpert MTB/RIF and/or liquid TB culture was a reference standard. Those designated probable TB patients were sputum Xpert MTB/RIF and/ TB culture negative, but started on TB treatment.en_ZA
dc.identifier.apacitationGina, N. P. (2016). <i>Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Division of Pulmonology. Retrieved from http://hdl.handle.net/11427/20834en_ZA
dc.identifier.chicagocitationGina, Ntombenhle Phindile. <i>"Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Division of Pulmonology, 2016. http://hdl.handle.net/11427/20834en_ZA
dc.identifier.citationGina, N. 2016. Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Gina, Ntombenhle Phindile AB - Point-of-care detection of urine lipoarabinomannan (LAM) is a low-cost rapid TB diagnostic for use in HIV co-infected patients. However, its sensitivity in these patients is suboptimal. Strategies to improve its performance is a need. The hypothesis was that early morning urine (EMU), rather than random urine sampling, would improve LAM's sensitivity. Methods Recruitment process conducted between June 2012 and February 2014 for HIV-infected patients from four hospitals in Cape Town, South Africa presenting with possible TB (all patients initiated on TB treatment). Fresh random and early morning urine (EMU) samples (~10-30 ml) collected in sterile containers. Following the manufacturer's instructions, an Alere Determine® TB Lateral flow assay performed on each sample, using both grade 1 and 2 cut-points. A single sputum Xpert MTB/RIF and/or liquid TB culture was a reference standard. Those designated probable TB patients were sputum Xpert MTB/RIF and/ TB culture negative, but started on TB treatment. DA - 2016 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2016 T1 - Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients TI - Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients UR - http://hdl.handle.net/11427/20834 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/20834
dc.identifier.vancouvercitationGina NP. Early morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patients. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Division of Pulmonology, 2016 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/20834en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDivision of Pulmonologyen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherInternal Medicineen_ZA
dc.titleEarly morning urine collection to improve the sensitivity of LAM in hospitalised TB/HIV co-infected patientsen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMMeden_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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