Predicting poor outcome Crohn's disease at the time of first diagnosis

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dc.contributor.advisorMyer, Landonen_ZA
dc.contributor.authorWatermeyer, Gillianen_ZA
dc.date.accessioned2014-11-08T18:08:31Z
dc.date.available2014-11-08T18:08:31Z
dc.date.issued2013en_ZA
dc.description.abstractOver time, the majority of patients with Crohn's disease (CD) will develop irreversible gastrointestinal (GIT) damage, notably strictures or fistulas, impacting negatively on quality of life and resulting in hospitilisation and surgery. Early and aggressive drug therapy with immunomodulators (IMMs) and biologics may alter the likelihood of these complications and improve long-term outcomes. However, this approach is extremely expensive and carries its own battery of side-effects such as infections and malignancy. In addition there are a sizable number of patients with CD who will have a benign disease course and never require potent medical therapies or surgical intervention. As a result, there has recently been a surge of interest in early identification of those people who are at risk of developing complicated disease. The aim of our study was thus to indentify predictive factors for poor outcome CD in a South African setting, in order to select those who would most benefit from early and aggressive medical therapies.en_ZA
dc.identifier.apacitationWatermeyer, G. (2013). <i>Predicting poor outcome Crohn's disease at the time of first diagnosis</i>. (Thesis). University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine. Retrieved from http://hdl.handle.net/11427/9420en_ZA
dc.identifier.chicagocitationWatermeyer, Gillian. <i>"Predicting poor outcome Crohn's disease at the time of first diagnosis."</i> Thesis., University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2013. http://hdl.handle.net/11427/9420en_ZA
dc.identifier.citationWatermeyer, G. 2013. Predicting poor outcome Crohn's disease at the time of first diagnosis. University of Cape Town.en_ZA
dc.identifier.ris TY - Thesis / Dissertation AU - Watermeyer, Gillian AB - Over time, the majority of patients with Crohn's disease (CD) will develop irreversible gastrointestinal (GIT) damage, notably strictures or fistulas, impacting negatively on quality of life and resulting in hospitilisation and surgery. Early and aggressive drug therapy with immunomodulators (IMMs) and biologics may alter the likelihood of these complications and improve long-term outcomes. However, this approach is extremely expensive and carries its own battery of side-effects such as infections and malignancy. In addition there are a sizable number of patients with CD who will have a benign disease course and never require potent medical therapies or surgical intervention. As a result, there has recently been a surge of interest in early identification of those people who are at risk of developing complicated disease. The aim of our study was thus to indentify predictive factors for poor outcome CD in a South African setting, in order to select those who would most benefit from early and aggressive medical therapies. DA - 2013 DB - OpenUCT DP - University of Cape Town LK - https://open.uct.ac.za PB - University of Cape Town PY - 2013 T1 - Predicting poor outcome Crohn's disease at the time of first diagnosis TI - Predicting poor outcome Crohn's disease at the time of first diagnosis UR - http://hdl.handle.net/11427/9420 ER - en_ZA
dc.identifier.urihttp://hdl.handle.net/11427/9420
dc.identifier.vancouvercitationWatermeyer G. Predicting poor outcome Crohn's disease at the time of first diagnosis. [Thesis]. University of Cape Town ,Faculty of Health Sciences ,Department of Public Health and Family Medicine, 2013 [cited yyyy month dd]. Available from: http://hdl.handle.net/11427/9420en_ZA
dc.language.isoengen_ZA
dc.publisher.departmentDepartment of Public Health and Family Medicineen_ZA
dc.publisher.facultyFaculty of Health Sciencesen_ZA
dc.publisher.institutionUniversity of Cape Town
dc.subject.otherPublic Health and Family Medicineen_ZA
dc.titlePredicting poor outcome Crohn's disease at the time of first diagnosisen_ZA
dc.typeMaster Thesis
dc.type.qualificationlevelMasters
dc.type.qualificationnameMPHen_ZA
uct.type.filetypeText
uct.type.filetypeImage
uct.type.publicationResearchen_ZA
uct.type.resourceThesisen_ZA
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